本文關鍵詞： 吉蘭—巴雷綜合征 Cerebrolysin 藥物治療　出處：《吉林大學》2014年碩士論文　論文類型：學位論文

【摘要】：目的： 復習并總結周圍神經病變的發(fā)病機制、臨床表現及治療方法。選取神經營養(yǎng)及神經保護藥物Cerebrolysin治療吉蘭—巴雷綜合征(GBS)，觀察療效，評定安全性。 方法： 選取我院收治的111例GBS患者，所有臨床表現及輔助檢查結果等均符合Asbury1990診斷標準。分為6組，分別為一般治療組（a1、a2組），激素治療組（b1、b2組），丙種球蛋白治療組（c1、c2組），1為空白對照組，2為Cerebrolysin治療實驗組。一般治療組僅給予常規(guī)神經營養(yǎng)藥物，激素治療組和丙球治療組在應用常規(guī)神經營養(yǎng)藥物的基礎上，分別給予激素和丙球治療。各治療方案組內實驗組給予含有20ml Cerebrolysin的250ml生理鹽水，每日1次靜點，對照組不給予Cerebrolysin，共10天。在治療10天時及治療后30天觀察記錄患者肌力評分及TCSS評分，治療后30天復查肌電圖，記錄MCV和Amp。將結果進行統計學分析。 結果： 治療10天時，患者在肌力評分、TCSS評分均未見顯著性改變（P＞0.05）。療程結束后30天，肌力恢復方面，除a組外，各治療方案組治療后30天以及治療后30天與治療前的差值實驗組與對照組比較均有統計學差異（P＜0.05）；治療后30天，各組患者的TCSS評分均有明顯改善，且各治療方案組內實驗組TCSS評分顯著低于對照組，具備統計學意義（P＜0.05）；神經電生理檢查方面，治療后30天各治療方案組MCV和Amp均有改善，各治療方案組內實驗組與對照組MCV和Amp比較，存在顯著的統計學差異（P0.05）。 結論： Cerebrolysin有助于修復受損的周圍神經，，對GBS患者的臨床癥狀、體征、MCV和Amp等方面均有不同程度的改善。
[Abstract]:Objective: To review and summarize the pathogenesis, clinical manifestation and treatment of peripheral neuropathy. Select neurotrophic and neuroprotective drug Cerebrolysin to treat Guillain-Barre syndrome (GBSs). Observe curative effect and evaluate safety. Methods: 111 patients with GBS were selected. All the clinical manifestations and the results of auxiliary examination were in accordance with the diagnostic criteria of Asbury1990. They were divided into 6 groups: general treatment group (A-1). Group A _ 2, steroid treatment group, B _ (1) B _ (2) group, and gamma globulin group (C _ (1) C _ (2)) as blank control group. 2 the experimental group was treated with Cerebrolysin. The general treatment group was given only routine neurotrophic drugs, while the hormone treatment group and the C ball treatment group were treated on the basis of routine neurotrophic drugs. The experimental group was given 250ml saline containing 20ml Cerebrolysin once a day. The control group was not given Cerebrolysin for 10 days. The muscle strength score and TCSS score were recorded on the 10th day of treatment and 30 days after treatment, and the electromyography was rechecked 30 days after treatment. MCV and AMPC were recorded. The results were statistically analyzed. Results: After 10 days of treatment, there was no significant change in the muscle strength score and TCSS score (P > 0.05). 30 days after the treatment, the muscle strength was recovered except in group A. The difference of 30 days after treatment, 30 days after treatment and 30 days after treatment in the experimental group and the control group were significantly different (P < 0.05). 30 days after treatment, the TCSS scores of the patients in each group were significantly improved, and the TCSS score in the experimental group was significantly lower than that in the control group (P < 0.05). The MCV and Amp of each treatment group were improved 30 days after treatment. The MCV and Amp of the experimental group were compared with those of the control group. There was significant statistical difference (P 0.05). Conclusion: Cerebrolysin is helpful to repair the injured peripheral nerve and improve the clinical symptoms, signs and Amp in patients with GBS.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R745.43

【參考文獻】

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本文編號：1447534