本文關(guān)鍵詞： 吉蘭—巴雷綜合征 Cerebrolysin 藥物治療　出處：《吉林大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的： 復(fù)習(xí)并總結(jié)周圍神經(jīng)病變的發(fā)病機(jī)制、臨床表現(xiàn)及治療方法。選取神經(jīng)營(yíng)養(yǎng)及神經(jīng)保護(hù)藥物Cerebrolysin治療吉蘭—巴雷綜合征(GBS)，觀察療效，評(píng)定安全性。 方法： 選取我院收治的111例GBS患者，所有臨床表現(xiàn)及輔助檢查結(jié)果等均符合Asbury1990診斷標(biāo)準(zhǔn)。分為6組，分別為一般治療組（a1、a2組），激素治療組（b1、b2組），丙種球蛋白治療組（c1、c2組），1為空白對(duì)照組，2為Cerebrolysin治療實(shí)驗(yàn)組。一般治療組僅給予常規(guī)神經(jīng)營(yíng)養(yǎng)藥物，激素治療組和丙球治療組在應(yīng)用常規(guī)神經(jīng)營(yíng)養(yǎng)藥物的基礎(chǔ)上，分別給予激素和丙球治療。各治療方案組內(nèi)實(shí)驗(yàn)組給予含有20ml Cerebrolysin的250ml生理鹽水，每日1次靜點(diǎn)，對(duì)照組不給予Cerebrolysin，共10天。在治療10天時(shí)及治療后30天觀察記錄患者肌力評(píng)分及TCSS評(píng)分，治療后30天復(fù)查肌電圖，記錄MCV和Amp。將結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析。 結(jié)果： 治療10天時(shí)，患者在肌力評(píng)分、TCSS評(píng)分均未見顯著性改變（P＞0.05）。療程結(jié)束后30天，肌力恢復(fù)方面，除a組外，各治療方案組治療后30天以及治療后30天與治療前的差值實(shí)驗(yàn)組與對(duì)照組比較均有統(tǒng)計(jì)學(xué)差異（P＜0.05）；治療后30天，各組患者的TCSS評(píng)分均有明顯改善，且各治療方案組內(nèi)實(shí)驗(yàn)組TCSS評(píng)分顯著低于對(duì)照組，具備統(tǒng)計(jì)學(xué)意義（P＜0.05）；神經(jīng)電生理檢查方面，治療后30天各治療方案組MCV和Amp均有改善，各治療方案組內(nèi)實(shí)驗(yàn)組與對(duì)照組MCV和Amp比較，存在顯著的統(tǒng)計(jì)學(xué)差異（P0.05）。 結(jié)論： Cerebrolysin有助于修復(fù)受損的周圍神經(jīng)，，對(duì)GBS患者的臨床癥狀、體征、MCV和Amp等方面均有不同程度的改善。
[Abstract]:Objective: To review and summarize the pathogenesis, clinical manifestation and treatment of peripheral neuropathy. Select neurotrophic and neuroprotective drug Cerebrolysin to treat Guillain-Barre syndrome (GBSs). Observe curative effect and evaluate safety. Methods: 111 patients with GBS were selected. All the clinical manifestations and the results of auxiliary examination were in accordance with the diagnostic criteria of Asbury1990. They were divided into 6 groups: general treatment group (A-1). Group A _ 2, steroid treatment group, B _ (1) B _ (2) group, and gamma globulin group (C _ (1) C _ (2)) as blank control group. 2 the experimental group was treated with Cerebrolysin. The general treatment group was given only routine neurotrophic drugs, while the hormone treatment group and the C ball treatment group were treated on the basis of routine neurotrophic drugs. The experimental group was given 250ml saline containing 20ml Cerebrolysin once a day. The control group was not given Cerebrolysin for 10 days. The muscle strength score and TCSS score were recorded on the 10th day of treatment and 30 days after treatment, and the electromyography was rechecked 30 days after treatment. MCV and AMPC were recorded. The results were statistically analyzed. Results: After 10 days of treatment, there was no significant change in the muscle strength score and TCSS score (P > 0.05). 30 days after the treatment, the muscle strength was recovered except in group A. The difference of 30 days after treatment, 30 days after treatment and 30 days after treatment in the experimental group and the control group were significantly different (P < 0.05). 30 days after treatment, the TCSS scores of the patients in each group were significantly improved, and the TCSS score in the experimental group was significantly lower than that in the control group (P < 0.05). The MCV and Amp of each treatment group were improved 30 days after treatment. The MCV and Amp of the experimental group were compared with those of the control group. There was significant statistical difference (P 0.05). Conclusion: Cerebrolysin is helpful to repair the injured peripheral nerve and improve the clinical symptoms, signs and Amp in patients with GBS.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R745.43

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 魏華;譚春蘭;熊e

本文編號(hào)：1447534