本文關(guān)鍵詞：右美托咪定對(duì)神經(jīng)外科手術(shù)病人麻醉蘇醒期血流動(dòng)力學(xué)指標(biāo)影響，由筆耕文化傳播整理發(fā)布。

右美托咪定對(duì)神經(jīng)外科手術(shù)病人麻醉蘇醒期血流動(dòng)力學(xué)指標(biāo)影響

EFFECT OF DEXMEDETOMIDINE ON HAEMODYNAMICS AT STAGE OF ANALEPSIA IN PATIENTS UNDERGOING NEUROSURGERY

[1] [2] [3] [4]

CHEN Sijia,ZHANG Lin,WANG Shiduan,SHI Caifeng（Department of Anesthesiology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China）

青島大學(xué)醫(yī)學(xué)院附屬醫(yī)院麻醉科,山東青島266003

文章摘要：目的探討右美托咪定（DEX）對(duì)神經(jīng)外科手術(shù)病人麻醉蘇醒期血流動(dòng)力學(xué)指標(biāo)的影響。方法選擇神經(jīng)外科手術(shù)病人50例,分為生理鹽水對(duì)照組（C組）和DEX組（D組）,誘導(dǎo)插管后隨機(jī)泵注生理鹽水或0.8μg.kg-1.h-1 DEX至硬膜完全關(guān)閉。根據(jù)腦電雙頻譜指數(shù)（BIS）調(diào)節(jié)丙泊酚輸注速度,記錄兩組術(shù)前、用藥前、停藥后及拔管期間血壓、心率以及舒芬太尼使用總量。拔管后15min內(nèi)記錄病人嗆咳次數(shù)、氧合不足的情況。結(jié)果兩組病人拔管時(shí)心率均有所上升,C組更明顯（t=2.355,P〈0.05）。D組拔管期血壓比C組明顯降低（t=4.106～4.456,P〈0.05）。舒芬太尼及丙泊酚使用量C組也多于D組（t=4.605、6.591,P〈0.05）。D組嗆咳次數(shù)顯著少于C組（u=4.000,P〈0.05）。結(jié)論 DEX可明顯改善神經(jīng)外科手術(shù)病人麻醉蘇醒期血流動(dòng)力學(xué)指標(biāo)的穩(wěn)定性。

Abstr：Objective To investigate the effect of dexmedetomidine（DEX） on haemodynamics during stage of analepsia in patients undergoing neurosurgery.Methods Fifty patients who received neurosurgical procedures were divided into control group and DEX group.After induced intubation,they were randomly allocated to either DEX 0.8 μg·kg-1·h-1 or normal saline until the endocranium was completely closed.Dosage of propofol was adjusted based on the changes of BIS value.The blood pressure,heart rate of the patients before surgery and medication,after drug withdrawal,at extubation,and total amount of sufentanil used were recorded.The frequency of bucking and under-oxygenation within 15 minutes after extubation were recorded.ResultsAt removal of tracheal tube,the heart rate of patients increased in both groups,more obviously were in the control group（t=2.355,P0.05）.The blood pressure in DEX group declined more versus the control（t=4.106-4.456,P0.05）;the dosages of sufentanil and propofol used were higher in the control than that in the DEX group（t=4.605,6.591;P0.05）.The frequency of bucking was fewer in the DEX than the control（u=4.000,P0.05）.Conclusion DEX can improve the stability of parameters of haemodynamics in patients undergoing neurosurgery during their stage of analepsia.

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Keyword：:dexmedetomidine neurosurgical procedures anesthesia recovery period

  本文關(guān)鍵詞：右美托咪定對(duì)神經(jīng)外科手術(shù)病人麻醉蘇醒期血流動(dòng)力學(xué)指標(biāo)影響，由筆耕文化傳播整理發(fā)布。