發(fā)布時(shí)間：2018-01-02 14:07

  本文關(guān)鍵詞：少突膠質(zhì)細(xì)胞瘤中FABP5的表達(dá)及其臨床意義　出處：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2016年12期 　論文類(lèi)型：期刊論文

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【摘要】：目的探討脂肪酸結(jié)合蛋白5(fatty acid-binding protein 5,FABP5)在少突膠質(zhì)細(xì)胞瘤中的表達(dá)及其臨床意義。方法采用免疫組化En Vision兩步法檢測(cè)87例人腦少突膠質(zhì)細(xì)胞瘤以及23例腫瘤旁腦組織中FABP5及Ki-67的表達(dá)。分析FABP5在少突膠質(zhì)細(xì)胞瘤中的表達(dá)與Ki-67、臨床病理參數(shù)以及預(yù)后的關(guān)系。結(jié)果 (1)FABP5在少突膠質(zhì)細(xì)胞瘤中高表達(dá)率為63.2%(55/87),顯著高于腫瘤旁腦組織(34.8%,8/23)(P0.05);(2)FABP5在少突膠質(zhì)細(xì)胞瘤中的表達(dá)與組織學(xué)分級(jí)(P=0.018,rs=0.254)、Ki-67表達(dá)呈正相關(guān)(P=0.003,rs=0.318);(3)單因素生存分析顯示,FABP5蛋白、Ki-67、化療、年齡與少突膠質(zhì)細(xì)胞瘤患者預(yù)后相關(guān)(P0.05)。結(jié)論 FABP5可能在少突膠質(zhì)細(xì)胞瘤的發(fā)生、發(fā)展過(guò)程中發(fā)揮重要作用,有望成為判斷少突膠質(zhì)細(xì)胞瘤患者疾病進(jìn)展及預(yù)后的生物學(xué)指標(biāo)。
[Abstract]:Objective to investigate fatty acid binding protein 5 fatty acid-binding protein 5. FABP5). In oligodendrocytoma and its clinical significance. Methods Immunohistochemical en was used. The expression of FABP5 and Ki-67 in 87 cases of oligodendrocytoma and 23 cases of paraneoplastic brain tissue were detected by Vision two-step method. The expression of FABP5 in oligodendrocytoma was analyzed. Ki-67. Results the high expression rate of FABP5 in oligodendrocytoma was 63.255 / 87, which was significantly higher than that in paratumor brain tissue (34.8%). 8 / 23 P0.05; The expression of FABP5 in oligodendrocytoma was positively correlated with the expression of Ki-67 in the histologic grade (P0. 018 ~ 0. 254) of oligodendrocytoma. The expression of FABP5 in oligodendrocytoma was positively correlated with the expression of Ki-67. RSM 0.318; Univariate survival analysis showed FABP5 protein Ki-67, chemotherapy. Age is associated with prognosis of oligodendrocytoma. Conclusion FABP5 may play an important role in the occurrence and development of oligodendrocytoma. It is expected to be a biological index to judge the disease progression and prognosis in oligodendrocytoma patients.
【作者單位】： 安徽醫(yī)科大學(xué)病理學(xué)教研室;安徽醫(yī)科大學(xué)第一附屬醫(yī)院病理科;
【基金】：國(guó)家自然科學(xué)基金(81201052)
【分類(lèi)號(hào)】：R739.41
【正文快照】： 作者單位:1安徽醫(yī)科大學(xué)病理學(xué)教研室,合肥2300322安徽醫(yī)科大學(xué)第一附屬醫(yī)院病理科,合肥230022膠質(zhì)瘤是中樞神經(jīng)系統(tǒng)中最為常見(jiàn)的原發(fā)性腫瘤,少突膠質(zhì)細(xì)胞瘤(oligodendroglioma)屬于膠質(zhì)瘤的一種獨(dú)立類(lèi)型,占顱內(nèi)腫瘤的4%~5%[1]。由于少突膠質(zhì)細(xì)胞瘤具有獨(dú)特的分子遺傳學(xué)改變、，

本文編號(hào)：1369544