【摘要】：目的比較丙泊酚TCI復(fù)合不同劑量芬太尼行患兒支氣管異物取出術(shù)的麻醉效果,并尋找適宜的芬太尼血藥濃度。方法選擇急診行支氣管異物取出術(shù)患兒200例,男107例,女93例,年齡8個月~2歲,體重8.3~12.0kg,ASAⅡ或Ⅲ級,隨機分為四組:芬太尼1μg/kg組(A組)、芬太尼1.5μg/kg組(B組)、芬太尼2μg/kg組(C組)和芬太尼2.5μg/kg組(D組),每組50例。均復(fù)合丙泊酚TCI 4μg/ml,記錄給藥后5min硬支氣管鏡一次性置入的成功例數(shù)和呼吸抑制情況,并采集此時患兒的動脈血,測定芬太尼的血藥濃度。結(jié)果 C組患兒麻醉效果理想,硬支氣管鏡一次性置入成功率(96%)明顯高于A組(20%)和B組(36%),呼吸抑制發(fā)生率(8%)明顯低于D組(36%)。C組血液中芬太尼有效靶濃度是(0.62±0.23)μg/L。結(jié)論芬太尼2μg/kg復(fù)合靶控輸注丙泊酚4μg/ml用于患兒支氣管異物取出術(shù)麻醉較平穩(wěn),血漿中芬太尼的血藥濃度是(0.62±0.23)μg/L。
[Abstract]:Objective to compare the anesthetic effects of propofol TCI combined with different doses of fentanyl in bronchial foreign body removal in children and to find the appropriate concentration of fentanyl in blood. Methods 200 children (107 males and 93 females) with acute bronchial foreign body removal, aged 8 months or 2 years, weighing 8.3 ~ 12.0 kg / kg, were selected for ASA 鈪，

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