本文選題：瘢痕疙瘩 + 重組人血管內皮抑制素��； 參考：《西南醫(yī)科大學》2017年碩士論文

【摘要】：目的:探討重組人血管抑制素治療瘢痕疙瘩的有效性及安全性。方法:將2015年1月-2016年1月在南充市中心醫(yī)院就診的瘢痕疙瘩患者64例按隨機數(shù)字法分為觀察組和對照組,各組32例。兩組患者均進行超脈沖二氧化碳點陣激光治療。術前、術后測量計算瘢痕表面積并建電子檔記錄,多病灶按單個之和計算總面積,簽署溝通記錄與操作同意書,局部清潔皮膚并外用表面麻醉藥物復方利多卡乳膏,麻醉顯效后設置治療參數(shù)(能量、密度及脈沖頻率)進行治療,治療后給予局部冷敷降溫及外涂莫匹羅星軟膏預防感染,對照組患者常規(guī)給予口服抗氧化藥物維生素C和抗菌藥物治療;觀察組患者在對照組抗氧化藥物維生素C和抗菌藥物治療基礎上,加用重組人血管內皮抑制素注射液瘢痕內注射,注射劑量為0.1~0.2 mg/cm2,每月治療1次,完成3次治療。比較兩組患者的臨床療效,癥狀改善評分比較,創(chuàng)面愈合時間比較;治療滿意度比較,以及不良反應發(fā)生情況。結果:觀察組和對照組患者的總有效率(93.75%vs.87.50%)和不良反應發(fā)生率(12.50%vs.9.38%)比較,差異均無統(tǒng)計學意義(P0.05)。對比治療后3月,觀察組臨床癥狀包括瘙癢和灼痛感改善評分均高于對照組,差異均有統(tǒng)計學意義(P0.05),觀察組患者的創(chuàng)面結痂時間、脫痂時間及創(chuàng)面完全愈合時間比較均明顯短于對照組,差異均有統(tǒng)計學意義(P0.05),觀察組的滿意度優(yōu)于對照組。結論:重組人血管內皮抑制素結合激光治療瘢痕疙瘩的臨床療效與單純激光治療無顯著差異,但能夠縮短創(chuàng)面愈合時間,緩解瘢痕疙瘩的瘙癢及疼痛,且用安全性較好。
[Abstract]:Objective: to investigate the efficacy and safety of recombinant human angiostatin in the treatment of keloid. Methods: from January 2015 to January 2016, 64 keloid patients in Nanchong Central Hospital were randomly divided into observation group (n = 32) and control group (n = 32). Two groups of patients were treated with super pulse carbon dioxide lattice laser. Before and after operation, the surface area of scar was measured and an electronic record was established. The total area of multiple lesions was calculated according to a single sum, and the communication record and operation consent were signed, the skin was locally cleaned and the topical anesthetic compound lidoca cream was used. The parameters (energy, density and pulse frequency) were set up after the anesthesia became effective. After the treatment, local cold compress and mupiroxine ointment were given to prevent infection. The patients in the control group were routinely treated with oral antioxidation drug vitamin C and antimicrobial agents, while the patients in the observation group were treated with vitamin C and antimicrobial drugs on the basis of the antioxidant drugs in the control group. Recombinant human vascular endotheliostatin injection was injected into the scar with a dose of 0.1 渭 m ~ (2) mg / cm ~ (-2) once a month for 3 times. The clinical efficacy, symptom improvement score, wound healing time, treatment satisfaction and adverse reactions were compared between the two groups. Results: there was no significant difference in the total effective rate (93.75vs.87.50) and the incidence of adverse reactions (12.50 vs 9.38) between the observation group and the control group (P 0.05). The scores of clinical symptoms including pruritus and burning pain in the observation group were higher than those in the control group three months after the contrast treatment, and the difference was statistically significant (P 0.05). The scabbing time of the patients in the observation group was higher than that in the control group. The time of eschar removal and the time of complete wound healing were significantly shorter than those of the control group (P 0.05). The satisfaction of the observation group was better than that of the control group. Conclusion: the clinical efficacy of recombinant human vascular endothelial inhibin combined with laser in treating keloid is not significantly different from that of laser alone, but it can shorten the wound healing time, relieve the pruritus and pain of keloid, and have good safety.
【學位授予單位】：西南醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R622

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