本文選題：纖維蛋白原 + 手術(shù)期間　； 參考：《重慶醫(yī)學(xué)》2015年10期

【摘要】：目的探討術(shù)前纖維蛋白原(FIB)單次目標(biāo)給藥,對(duì)腰椎后路減壓椎間植骨融合內(nèi)固定術(shù)(PLIF)術(shù)中出血及凝血功能的影響。方法選擇腰椎間盤突出癥(LDH)擇期做PLIF的患者60例,依據(jù)術(shù)前FIB水平分為FIB≥3.0g/L組(NC組,n=20)和低FIB組(FIB3.0g/L,n=40),低FIB組再分為低FIB對(duì)照組(LC組,n=20)和術(shù)前FIB單次給藥組(PF組,n=20)。PF組于麻醉誘導(dǎo)完成后輸入纖維蛋白原;LC、NC組于麻醉誘導(dǎo)完成后輸入纖維蛋白原劑量所需溶媒等容積的生理鹽水。3組患者于給藥前、后測(cè)定凝血4項(xiàng)及用凝血和血小板功能分析儀測(cè)定激活凝血時(shí)間(ACT)、凝血速率(CR)、血小板功能(PF),術(shù)畢稱量出血量。結(jié)果 FIB在給藥后PF組為(3.75±0.23)g/L,明顯高于NC組(2.62±0.33)g/L和LC組(2.23±0.22)g/L,3組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);CR值在給藥后PF組為(21.42±7.15)U/min,高于NC組(18.21±5.62)U/min和LC組(15.21±5.63)U/min。PF組出血量為(516.74±135.53)g,低于NC組(660.71±119.34)g和LC組(726.72±160.47)g,3組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論術(shù)前FIB單次目標(biāo)給藥可以有效提高FIB水平及凝血功能,減少圍術(shù)期出血量。
[Abstract]:Objective to investigate the effect of single target administration of fibrinogen FIBbefore operation on bleeding and coagulation in posterior lumbar decompression, intervertebral fusion and internal fixation. Methods 60 PLIF patients with lumbar disc herniation were selected. According to the preoperative FIB level, they were divided into three groups: FIB 鈮，

本文編號(hào)：1954510