本文選題：丙泊酚　切入點：地佐辛　出處：《醫(yī)學綜述》2016年21期

【摘要】：目的研究丙泊酚聯(lián)合地佐辛對老年無痛腸鏡應(yīng)激指標的影響。方法選取2014年3月至2015年4月收入無錫市錫山人民醫(yī)院行無痛腸鏡的老年患者220例為研究對象。按隨機數(shù)字表法分為觀察組和對照組,各110例。觀察組使用地佐辛和丙泊酚聯(lián)合麻醉(先靜脈緩慢注射5 mg地佐辛,10 min后,靜脈注射2.0 mg/kg丙泊酚),對照組僅使用丙泊酚麻醉(靜脈注射2.0 mg/kg丙泊酚),并對兩組收縮壓、舒張壓、心率及脈搏血氧飽和度(SpO_2),丙泊酚用量、蘇醒時間及視覺模擬評分(VAS),不良反應(yīng)及應(yīng)激指標進行比較。結(jié)果術(shù)中,兩組生命體征平穩(wěn),未出現(xiàn)麻藥物過敏現(xiàn)象。術(shù)中,觀察組收縮壓、舒張壓、心率均較對照組顯著降低[(105.69±8.77)mmHg(1 mmH g=0.133 k Pa)比(122.14±9.46)mmHg、(62.34±6.76)mmHg比(78.01±9.41)mmHg、(71.30±6.44)次/min比(80.58±10.32)次/min],SpO_2較對照組顯著增加[(0.986±0.011)比(0.947±0.010)],差異有統(tǒng)計學意義(P0.05)。觀察組術(shù)中丙泊酚用量顯著低于對照組[(82±8)mg比(123±19)mg],差異有統(tǒng)計學意義(P0.05)。術(shù)后,兩組蘇醒時間差異無統(tǒng)計學意義(P0.05)。與對照組相比,觀察組術(shù)后不良反應(yīng)較少,僅3例出現(xiàn)惡心嘔吐,對照組不良反應(yīng)種類及例數(shù)較多,觀察組不良反應(yīng)發(fā)生率低于對照組,差異有統(tǒng)計學意義(P0.05)。兩組術(shù)中、術(shù)后皮質(zhì)醇和血管緊張素Ⅱ水平均呈先升高后降低趨勢,觀察組變化幅度更小,兩組在組間、時點間、組間·時點間交互作用差異有統(tǒng)計學意義(P0.05)。結(jié)論丙泊酚聯(lián)合地佐辛用于對老年無痛腸鏡檢查和治療中,具有治療方便,安全性好,應(yīng)激反應(yīng)小的特點,值得臨床推廣應(yīng)用。
[Abstract]:Objective to study the effect of propofol combined with dizosin on the stress index of painless enteroscopy in the elderly. Methods 220 elderly patients who received painless endoscopy from March 2014 to April 2015 in Xishan people's Hospital of Wuxi City were selected as the study objects. The method of random digital table was divided into observation group and control group. One hundred and ten patients in each group were treated with dizosin and propofol combined anesthesia (intravenous injection of 5 mg dizosin for 10 min, intravenous injection of 2.0 mg/kg propofol), and control group only with propofol anesthesia (intravenous injection of 2.0 mg/kg propofol, and systolic blood pressure in both groups). Diastolic blood pressure (DBP), heart rate (HR) and pulse oxygen saturation (SPO _ 2), propofol dosage, recovery time and visual analogue score (VASA), adverse reactions and stress indexes were compared. Results during the operation, the vital signs of the two groups were stable, and no anaphylaxis occurred during the operation. Systolic blood pressure, diastolic blood pressure, The heart rate was significantly lower than that in the control group [105.69 鹵8.77)mmHg(1 mmH 0.133 KPA] than that in the control group (122.14 鹵9.46 6.76)mmHg vs 78.01 鹵9.41 6.76)mmHg vs 78.01 鹵9.41mm / min vs 80.58 鹵10.32kPa / min), and the difference was statistically significant (P 0.05). The dosage of propofol in the observation group was significantly lower than that in the control group [82 鹵8)mg vs 123 鹵19)mg], and the difference was significant in comparison with the control group (P < 0.05), and the dosage of propofol in the observation group was significantly lower than that in the control group [82 鹵8)mg vs 123 鹵19)mg]. The significance of calculation is P0.05. after operation, There was no significant difference in the recovery time between the two groups (P 0.05). Compared with the control group, the adverse reactions in the observation group were less, only 3 cases had nausea and vomiting, and the type and number of adverse reactions in the control group were more than those in the control group. The incidence of adverse reactions in the observation group was lower than that in the control group. During the operation, the levels of cortisol and angiotensin 鈪，

本文編號：1660682