本文選題：祛瘀化痰通脈通脈顆粒　切入點(diǎn)：心臟血流動(dòng)力學(xué)　出處：《中國(guó)實(shí)驗(yàn)方劑學(xué)雜志》2017年09期

【摘要】：目的:評(píng)價(jià)祛瘀化痰通脈顆粒對(duì)麻醉比格犬心臟血流動(dòng)力學(xué)及心肌耗氧量的影響。方法:采用開(kāi)胸手術(shù)觀察祛瘀化痰通脈顆粒對(duì)麻醉比格犬血流動(dòng)力學(xué)及心肌耗氧量影響,比格犬30只,隨機(jī)分為5組(每組6只),分別為正常組,合心爽組(5 mg·kg~(-1)),祛瘀化痰通脈顆粒高、中、低劑量組(2.0,1.0,0.5 g·kg~(-1)),經(jīng)十二指腸給予相應(yīng)藥物,用多道生理記錄儀分別測(cè)量動(dòng)脈血壓、心率、肢體標(biāo)準(zhǔn)Ⅱ?qū)?lián)心電圖、冠狀動(dòng)脈血流量、心輸出量、左室內(nèi)壓、左室內(nèi)壓上升最大速率。測(cè)定動(dòng)脈血氧含量、冠狀靜脈竇血氧含量,計(jì)算心肌耗氧量、心肌耗氧指數(shù)及氧利用率等指標(biāo)。結(jié)果:與正常組比較,祛瘀化痰通脈顆粒高、中劑量藥后可以動(dòng)物增加冠脈流量,降低冠脈阻力,祛瘀化痰通脈顆粒高、中劑量組藥后15~60 min心輸出量增加明顯,與自身藥前值及正常組比較均有統(tǒng)計(jì)學(xué)差異,祛瘀化痰通脈顆粒各劑量組藥后均有增加左室作功的作用,中劑量給藥后60 min見(jiàn)靜脈血氧含量上升19%左右,心肌耗氧量降低約21%,與正常組及自身藥前值比較均有統(tǒng)計(jì)學(xué)差異(P0.05,P0.01)。對(duì)心率、動(dòng)脈血壓、左室內(nèi)壓、左室內(nèi)壓上升最大速率、心肌耗氧指數(shù)等指標(biāo)未見(jiàn)明顯影響。結(jié)論:祛瘀化痰通脈顆粒可以改善比格犬心臟血流動(dòng)力學(xué)指標(biāo),提高心臟泵血功能,增加冠脈血流量,同時(shí)還可以降低心肌耗氧量,從而提高了心臟的工作效率。
[Abstract]:Objective: to evaluate the effect of Quyu Huatan Tongmai granule on cardiac hemodynamics and myocardial oxygen consumption in anesthetized Beagle dogs. Methods: the effects of Quyu Huatan Tongmai granule on hemodynamics and myocardial oxygen consumption in anesthetized Beagle dogs were observed by open chest surgery. Thirty Beagle dogs were randomly divided into 5 groups (6 rats in each group were normal group, Hexinshuang group was treated with 5 mg KGG, QYHuatan Tongmai granule was high, middle and low dosage group was 2. 0 ~ 1. 0% 0. 5 g KGDX), and the corresponding drugs were given through duodenum. Arterial blood pressure, heart rate, electrocardiogram (ECG) of limb standard 鈪，

本文編號(hào)：1655062