【摘要】：登革熱是由蚊蟲傳播登革熱病毒引起的急性傳染病，隨著城市化和全球一體化的快速發(fā)展、過分依賴殺蟲劑導(dǎo)致抗藥性等問題20世紀80年代以來流行越來越嚴重，全球每年有百多萬病例，近25億人口受到登革熱的威脅。我國自1978年廣東省再次爆發(fā)本病流行后，有不斷蔓延并向北移動擴散的趨勢。由于登革熱仍沒有特異性疫苗和治療藥物，所以加強登革熱及媒介監(jiān)測和控制仍是當前最有效的預(yù)防措施，WHO特別強調(diào)加強新型敏感的媒介監(jiān)測方法的研究。本課題來源于廣東省疾病預(yù)防控制中心的廣東省應(yīng)急病原檢測重點實驗室啟動研究項目，屬廣東省重點科技項目(2003B60127)。 本研究目的是根據(jù)登革熱必須通過蚊蟲的叮咬傳播和蚊蟲吸血后產(chǎn)卵的特點，研究開發(fā)對伊蚊特異性高的誘蚊誘卵器(Mosquito and oviposition trap，Mosq-ovitrap)，建立科學(xué)高效、簡便可行的監(jiān)測方法，既監(jiān)測社區(qū)環(huán)境伊蚊密度，又采集社區(qū)環(huán)境中吸血后最可能帶毒的蚊蟲，，利用PCR和細胞培養(yǎng)等技術(shù)對蚊蟲進行登革熱病毒的帶毒監(jiān)測，建立簡易、科學(xué)、可行的登革熱媒介的監(jiān)測體系，再結(jié)合登革熱疾病監(jiān)測，為建立登革熱可能流行的分級預(yù)警體系奠定基礎(chǔ)。 1．誘蚊誘卵器(Mosq-ovitrap)的設(shè)計開發(fā)研究：根據(jù)白紋伊蚊喜歡趨向黑色、在陰涼潮濕的場所棲息活動，吸血后需尋找容器清水型積水，并在潮濕粗糙表面上產(chǎn)卵的生態(tài)特點，參考美國開發(fā)的誘卵杯，結(jié)合誘蠅籠的捕蠅原理，有針對性設(shè)計誘蚊誘卵器。
[Abstract]:Dengue is an acute infectious disease caused by mosquito-borne dengue virus. With the rapid development of urbanization and global integration, it has become more and more serious since the 1980s, and more than a million cases of the world each year, Nearly 2.5 billion people are threatened by dengue fever. Since the outbreak of this disease in Guangdong Province in 1978, China has a tendency to spread and spread to the north. Since dengue still has no specific vaccine and therapeutic drug, it is still the most effective preventive measure to strengthen the monitoring and control of dengue and medium, and the WHO has placed special emphasis on strengthening the research of new sensitive media monitoring methods. This project is based on Guangdong Provincial Center for Disease Control and Prevention, the key laboratory for emergency pathogen detection in Guangdong Province, and belongs to the key science and technology project of Guangdong Province (2003B60127). The purpose of this study is to develop a scientific and efficient and feasible monitoring method for the development of a scientific and efficient and feasible monitoring method, based on the fact that dengue has to be spread through the bite of the mosquito and the characteristics of the oviposition after the mosquito sucks blood. in that invention, the density of the mosquito in the community environment is monitored, the mosquito which is most likely to be infected after the blood is sucked in the community environment is collected, the virus of the dengue virus is monitored by the technology of PCR and cell culture and the like, and a simple, scientific and feasible monitoring system of the dengue medium is established, in combination with that surveillance of dengue disease, it may be possible to establish dengue fever The foundation of the classification and early warning system is laid. 1. The design and development of the Moq-ovitrap: according to the tendency of the Aedes albopictus to tend to be black, live in a cool and humid place. After the blood is sucked, it is necessary to find the clear water type of the container and to be rough in the damp and rough. The ecological characteristic of laying eggs on the surface, referring to the development of the egg-inducing cup and the knot in the United States.
【學(xué)位授予單位】：第一軍醫(yī)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2006
【分類號】：R184

【引證文獻】

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1 于德憲;任旭琦;周文;廖玉學(xué);陳清;俞守義;;白紋伊蚊誘蚊誘卵器應(yīng)用效果的現(xiàn)場研究[J];熱帶醫(yī)學(xué)雜志;2008年04期

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