發(fā)布時間：2018-11-29 13:56

【摘要】：腎綜合征出血熱(Haemorrhagic Fever with Renal Syndrome，HFRS)是我國重點防治的傳染病之一，其特點是發(fā)病急、病情重、病死率高，，嚴(yán)重危害人群的生命和健康。山東省是我國HFRS發(fā)病最嚴(yán)重的地區(qū)之一，自1984年以來，每年發(fā)病人數(shù)都位于全國前列。為了有效控制山東省HFRS疫情，本研究根據(jù)山東省HFRS人間疫情以及宿主動物的監(jiān)測結(jié)果，采用相關(guān)的流行病學(xué)、統(tǒng)計學(xué)原理和方法，探討山東省HFRS的變化趨勢，為進一步開展HFRS防治工作提供依據(jù)。 目的：通過對2003—2005年山東省各市HFRS人間疫情、宿主動物感染情況進行分析，探討山東省HFRS人間疫情以及漢坦病毒(Hantavirus，HV)宿主動物的變化特點，并通過對山東省莒南縣2004年2月—2005年1月連續(xù)12個月的鼠情監(jiān)測，以及山東省莒南縣農(nóng)村人群中HV血清抗體的監(jiān)測，分析鼠種構(gòu)成、鼠密度、鼠帶病毒率、帶病毒鼠指數(shù)等指標(biāo)，掌握鼠情變化情況和人群的血清抗體水平，為控制山東省HFRS的發(fā)生和流行，切實有效的提高山東省HFRS防治效率提供理論依據(jù)。 方法：山東省2003—2005年HFRS疫情資料，來自山東省疾病預(yù)防控制中心，疫情資料為修正后資料。 宿主動物監(jiān)測，在山東省各市的HFRS監(jiān)測點用夾夜法、鼠籠法或者粘鼠板法捕鼠，鑒別鼠種，計算鼠密度，無菌條件下采集鼠肺，放在液氮罐或-70℃的冰箱中冷凍保存。鼠肺標(biāo)本用冷凍切片機切片后，用直接免疫熒光法或者間接免疫熒光法檢測鼠肺中是否攜帶HV。 山東省農(nóng)村人群中隱性感染情況的調(diào)查，用濾紙片采集健康人群的末梢血，晾干后，冷凍保存，用細胞抗原片通過間接免疫熒光法檢測血清中的HV抗體。
[Abstract]:Hemorrhagic fever with renal syndrome (Haemorrhagic Fever with Renal Syndrome,HFRS) is one of the most important infectious diseases in China. Shandong Province is one of the most serious HFRS cases in China. In order to effectively control the HFRS epidemic situation in Shandong Province, according to the surveillance results of human HFRS epidemic situation and host animals in Shandong Province, using the relevant epidemiological, statistical principles and methods, the change trend of HFRS in Shandong Province was discussed. To provide the basis for the further development of HFRS prevention and control work. Objective: to analyze the human HFRS epidemic situation and host animal infection in Shandong Province from 2003 to 2005, and to explore the characteristics of HFRS human epidemic situation and Hantavirus (Hantavirus,HV) host animals in Shandong Province. The composition of mouse species, the density of mice and the rate of carrying virus in mice were analyzed by monitoring the rat condition in Junan County, Shandong Province, from February 2004 to January 2005, and by monitoring the serum antibodies against HV in the rural population of Junan County, Shandong Province. In order to control the occurrence and prevalence of HFRS in Shandong Province and effectively improve the efficiency of HFRS prevention and treatment in Shandong Province, the index of virus carrying mice and the level of serum antibody of the population were grasped. Methods: the data of HFRS epidemic in Shandong Province from 2003 to 2005 were collected from the Center for Disease Control and Prevention of Shandong Province. Host animals were monitored. The HFRS monitoring sites in Shandong Province were collected by night-clamping method, cage method or stick plate method to identify rodent species, calculate rat density, collect rat lungs under aseptic conditions, and store them in liquid nitrogen tanks or refrigerators at -70 鈩

本文編號：2365172