【摘要】：目的: 分別探討低密度脂蛋白受體相關(guān)蛋白8(LRP8)和神經(jīng)肽Y2受體基因多態(tài)性對苯那普利降壓療效的影響。 方法: 選取中國安徽某兩地區(qū)原發(fā)性高血壓患者,服用苯那普利,每日10mg,追蹤觀察15天。測量服藥前后血壓值,調(diào)查人口學(xué)特征、測定其基因型并了解其分布特點,從其中選取降壓療效最好和最差的研究對象422人,研究苯那普利的降壓療效和LRP8及NPY2R基因的多態(tài)性的關(guān)系。 結(jié)果: 一LRP8基因多態(tài)性和苯那普利降壓療效的關(guān)系:(1) 研究人群在LRP8基因的不同基因型間年齡、體重、體質(zhì)指數(shù)、基線收縮壓、舒張壓下降值、當前是否吸煙、飲酒等因素差異均無顯著性;(2) HWE平衡檢驗未發(fā)現(xiàn)三種基因型的頻率有顯著性差異(x~2=3.45,p=0.063);(3) LRP8的基因突變后影響苯那普利的降壓療效,①在BMI24kg/m~2的原發(fā)性高血壓人群中LRP8的基因的突變組(AC)能使收縮壓比野生型(AA)的人群下降5.68mmHg(校正前β±SE:5.52±2.89mmHg,p=0.0562,校正后β±SE:5.68±2.52mmHg,p=0.0403);②在輕度原發(fā)性高血壓人群中(159=SBP=140mmHg or 99=DBP=90mmHg),LRP8的基因突變組(AC)能使收縮壓和舒張壓比野生型(AA)的人群分別下降6.14mmHg和3.81mmHg(收縮壓校正前β±SE:6.22+2.71mmHg,p=0.0215,校正后β±SE:6.14±2.58mmHg,p=0.0172;舒張壓校正前β±SE:3.69+1.95mmHg,p=0.0588,校正后β±SE:3.81±1.84mmHg,p=0.0387)。 二NPY2R基因多態(tài)性和苯那普利降壓療效的關(guān)系:(1) 研究人群在不同基因型間體重、腰圍、腰臀比差異有顯著性(p值分別為0.0322、0.0099和0.0108),
[Abstract]:Aim: to investigate the effects of low density lipoprotein receptor associated protein 8 (LRP8) and neuropeptide Y 2 receptor gene polymorphism on the antihypertensive effect of benazepril. Methods: 10 mg benazepril was administered to patients with essential hypertension in Anhui province of China for 15 days. Blood pressure was measured before and after medication, demographic characteristics were investigated, genotypes were determined and their distribution characteristics were investigated. 422 subjects with the best and worst antihypertensive effects were selected from the study. To study the relationship between the antihypertensive effect of benazepril and the polymorphism of LRP8 and NPY2R gene. Results: the relationship between the polymorphism of a LRP8 gene and the antihypertensive effect of benazepril: (1) the age, body weight, body mass index, baseline systolic blood pressure, diastolic blood pressure (DBP) of different genotypes of LRP8 gene were studied. There was no significant difference between smoking and drinking. (2) there was no significant difference in the frequency of the three genotypes by HWE equilibrium test (x2 + 3.45%). (3) the antihypertensive effect of benazepril was affected by LRP8 gene mutation. 1the mutation group (AC) of LRP8 gene in BMI24kg/m~2 patients with essential hypertension could reduce the systolic blood pressure (SBP) to 5.68mmHg (尾 鹵SE:5.52 鹵2.89mm HgGG 0.0562 before correction, 尾 鹵SE:5.68 鹵2.52mmHg after correction) compared with those of wild-type (AA). P0. 0403); 2in mild essential hypertension (159=SBP=140mmHg or 99=DBP=90mmHg), (AC) of LRP8 gene mutation group decreased 6.14mmHg and 3.81mmHg (尾 鹵SE:6.22 2.71mm Hg before systolic blood pressure correction) compared with wild-type (AA) patients. After correction, 尾 鹵SE:6.14 鹵2.58mm HgGG was 0.0172; Diastolic blood pressure (尾 鹵SE:3.69 1.95mm) was 0.0588mm, and 尾 鹵SE:3.81 鹵1.84mm HgGG (0.0387). The relationship between the polymorphism of NPY2R gene and the antihypertensive effect of benazepril: (1) there were significant differences in body weight, waist circumference and waist-to-hip ratio among different genotypes (p = 0.0322 鹵0.0099 and 0.0108, respectively).
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2005
【分類號】：R181.3

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