【摘要】：目的了解江蘇省健康人群脊髓灰質(zhì)炎中和抗體水平,為及時制定免疫策略、維持無脊灰狀態(tài)提供科學依據(jù)。方法采取江蘇省2009年-2013年健康人群血清標本,應(yīng)用細胞中和實驗法檢測脊灰中和抗體。SPSS 18.0統(tǒng)計軟件進行統(tǒng)計分析。結(jié)果共檢測3 000名健康人群的血清標本,脊灰Ⅰ、Ⅱ、Ⅲ型抗體陽性率分別為98.51%、98.37%、94.97%;幾何平均滴度(GMT)分別為1∶186.21、1∶125.89、1∶47.86;不同年份健康人群脊灰抗體陽性率和GMT無統(tǒng)計學意義(P0.05);不同年齡段健康人群脊灰抗體陽性率及GMT有統(tǒng)計學意義(P0.05),抗體水平總趨勢隨年齡增長遞減。結(jié)論江蘇省健康人群脊灰抗體陽性率和幾何平均滴度,近5年均保持在較高水平,接種脊灰疫苗可獲得較好的免疫保護。今后應(yīng)繼續(xù)保持高水平的免疫覆蓋率,進一步改進免疫策略及提高AFP病例監(jiān)測系統(tǒng)的敏感性,鞏固無脊灰成果。
[Abstract]:Objective to investigate the level of neutralizing antibody against poliomyelitis in healthy population in Jiangsu Province, and to provide scientific basis for the establishment of immune strategy and maintenance of poliomyelitis status. Methods Serum samples from healthy people in Jiangsu Province from 2009 to 2013 were used to detect neutralizing antibodies against poliomyelitis by cell neutralization test. SPSS 18.0 statistical software was used for statistical analysis. Results Serum samples of 3 000 healthy people were detected. The positive rates of type 鈪，

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