【摘要】：目的為了解接種了3針乙肝疫苗后1~8歲兒童人群乙肝抗-HBs滴度及陽(yáng)性率變化情況及影響因素,為制定國(guó)家免疫規(guī)劃政策提供依據(jù)。方法采取整群隨機(jī)抽樣方法采集四川省綿陽(yáng)市涪城區(qū)僅接受了國(guó)家3針免費(fèi)乙肝疫苗接種的城鄉(xiāng)兒童血清,采用雙抗原夾心時(shí)間分辨免疫熒光分析法(IFMA法)對(duì)乙肝表面抗體(抗-HBs)定量檢測(cè),采用χ~2檢驗(yàn)和方差分析進(jìn)行差異比較。結(jié)果本次共調(diào)查了符合條件的807名兒童,乙肝抗-HBs陽(yáng)性率為61.7%。兒童人群乙肝抗-HBs滴度和陽(yáng)性率在接種后3年內(nèi)下降最快,4-6歲波動(dòng)較大,6歲后回升到一定水平;乙肝抗-HBs滴度和陽(yáng)性率與性別、城鄉(xiāng)差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論已全程接種3針乙肝疫苗的兒童人群應(yīng)每間隔3年進(jìn)行1次乙肝血清標(biāo)志物檢測(cè),對(duì)乙肝抗-HBs陰性或滴度≤10mIU/ml者及時(shí)進(jìn)行加強(qiáng)免疫。
[Abstract]:Objective to investigate the changes of hepatitis B anti-HBs titer and positive rate in children aged 1 to 8 years after three doses of hepatitis B vaccine, and to provide evidence for the formulation of national immunization planning policy. Methods A cluster random sampling method was used to collect serum samples from urban and rural children in Fucheng District, Mianyang City, Sichuan Province, who received only 3 doses of free hepatitis B vaccine. Double antigen sandwich time resolved immunofluorescence assay (IFMA) was used to detect hepatitis B surface antibody (anti-HBs) quantitatively, 蠂 ~ 2 test and variance analysis were used to compare the difference. Results the positive rate of anti-HBs was 61.7 in 807 children. The titer and positive rate of anti-HBs in children decreased the fastest within 3 years after inoculation and increased to a certain level after 6 years old, but the titer and positive rate of anti-HBs were no significant difference between urban and rural areas. Conclusion the serum markers of hepatitis B should be detected once every 3 years in children who have been vaccinated with 3 doses of hepatitis B vaccine during the whole course, and the patients with anti-HBs negative or titer 鈮，

本文編號(hào)：2177339