河南農(nóng)村人群體脂率與心血管代謝性疾病的關(guān)系及篩檢效能評(píng)價(jià)
[Abstract]:Objective to understand the prevalence of obesity, type 2 diabetes, hypertension and dyslipidemia in rural areas of Henan, and to explore the relationship between body fat rate and type 2 diabetes, hypertension, dyslipidemia and other diseases, and to further evaluate the screening effectiveness of body fat rate on cardiovascular metabolic diseases. Methods a survey was conducted on 15885 subjects aged 18 to 74 in the study of "rural diabetes, obesity and lifestyle (RuralDiab)". A face-to-face survey was conducted to investigate the subjects, physical examination and collection of biological specimens, the measurement of body fat rate, and the use of Epidata 3.1 to establish a database. The consistency verification was carried out. The continuous variables were represented by mean number and standard deviation, and the group was compared with independent sample t test or variance analysis. The classification variables were expressed by frequency and percentage, and the group was compared by the chi 2 test. The body fat rate was divided into Q1, Q2, Q3, Q4 four groups according to the four division method, and the logistic regression model was used to evaluate the androgyny by the logistic regression model. Association between lipid and related diseases, correlation intensity was expressed with OR and 95%CI. The dose response relationship between body fat rate and cardiovascular metabolic disease was analyzed using a restrictive cubic spline model. The optimal point value and screening efficacy of body fat rate for screening the metabolic diseases of the heart and blood tube were analyzed by the subject work feature (ROC) curve. Results 1. studies were included in 5886 men and 9999 women. The prevalence rates of obesity, type 2 diabetes, hypertension and dyslipidemia were 14.70%, 9.04%, 28.56%, 34.79% in the male population, and the prevalence rates in women were 18.32%, 9.72%, 29.13%, respectively, among men were 19.90%, 6.25%, 20.85%, and 27.17%. years old, respectively. 41.62%; the distribution of cardiovascular metabolic diseases at different body fat rates of 16.28%, 5.77%, 18.27%, and 22.42%.2. in women: systolic pressure, diastolic blood pressure, fasting blood glucose, insulin levels, total cholesterol levels, triglycerides, low density lipoprotein cholesterol levels, and low density lipoprotein cholesterol levels in men and women. Increased (P trend 0.001); high density lipoprotein cholesterol levels decreased with the increase of body fat (P trend 0.001); the prevalence of type 2 diabetes, hypertension, and dyslipidemia increased with the increase of body fat rate (P trend 0.001) the relationship between the level of.3. body fat and cardiovascular metabolic diseases: after adjusting the related factors, Compared with the body fat rate Q1 group, Q2, Q3, Q4 were associated with the prevalence of cardiovascular metabolic diseases such as type 2 diabetes, hypertension and dyslipidemia, and the association intensity increased with the increase of body fat rate and the strongest association intensity in the Q4 group (P trend 0.001). The association intensity of the body fat rate Q4 group with type 2 diabetes (OR, 95%CI) was in the male population. 3.62 (2.66,4.93), the female population was 3.63 (2.07,3.34); the intensity of association with hypertension was 4.15 (3.43,5.01) and 3.14 (2.70,3.65) in the female population; the intensity of the association with dyslipidemia was 8.12 (6.69,9.84) in the male population and the dose response relationship between the 4.17 (3.57,4.86).4. body fat rate and the cardiovascular metabolic disease in the female population: The restrictive cubic spline shows that the association between body fat rate and type 2 diabetes, hypertension and dyslipidemia increases linearly with the increase of body fat; the increase and speed of the increase and speed of the association intensity of body fat and cardiovascular metabolic diseases in male population is greater than that in the female population; the intensity of body fat rate and blood lipid abnormality is at the body fat rate. Evaluation of the efficacy of a leveling.5. body fat rate screening for cardiovascular metabolic diseases at a certain level: in male populations, the best cut points of somatic fat rate screening for type 2 diabetes, hypertension and dyslipidemia were 25.4%, 25.5% and 24.2% respectively, and the area under the curve was the best cut point of the body fat rate in 0.681,0.661 and 0.672. women, respectively. The values were 33.7%, 34.7% and 32.5% respectively. The areas under the corresponding curves were 0.661,0.677 and 0.635. respectively. Conclusion 1. Henan rural people were obese, type 2 diabetes, hypertension and dyslipidemia and other cardiovascular metabolic diseases were not optimistic. The prevention and control of cardiovascular metabolic diseases should pay attention to the body fat rate of.2. and type 2 diabetes. The incidence of cardiovascular metabolic diseases, such as disease, hypertension, and dyslipidemia, is associated with an increase in the body fat rate and a nonlinear increase with the increase in the body fat rate. Therefore, the management of body fat rate and the control of the.3. body fat rate for type 2 diabetes, hypertension and blood should be strengthened in the health education work at the grass-roots level. The discriminating efficacy of lipid abnormality is limited, and the cut-off value of screening needs further validation in large sample population studies.
【學(xué)位授予單位】:鄭州大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2017
【分類號(hào)】:R181.3
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