本文選題：幽門螺桿菌 + 流行病學�。� 參考：《蘭州大學》2009年碩士論文

【摘要】： 目的了解胃癌高發(fā)地區(qū)甘肅省武威市成人、兒童和青少年幽門螺桿菌(H pylori,Hp)的感染情況,并對Hp感染相關因素進行分析,為本地區(qū)防治幽門螺桿菌提供科學依據(jù)。 方法于2007年10月至2008年5月對武威市不同人群進行Hp感染情況調(diào)查。(1)采用酶聯(lián)免疫吸附試驗(ELISA)檢測法對武威市城鄉(xiāng)居民中隨機抽取797例成人開展Hp感染率及相關因素的橫斷面研究。(2)采用幽門螺桿菌抗原檢測法對武威市938名3～18歲兒童或青少年和96戶家庭進行Hp糞便抗原檢測,并作Hp感染相關因素分析。(3)采用幽門螺桿菌免疫印跡法對經(jīng)Hp糞便抗原檢測陽性的80名兒童或青少年進行Hp毒力蛋白分析。所有調(diào)查均采用標準化問卷收集研究對象的個人疾病史、家族疾病史、危險因素、保護因素等信息。 結(jié)果(1)武威市成人Hp感染率為81.8%,且隨著年齡的增加有增加的趨勢。x~2檢驗分析結(jié)果提示,Hp感染可能與年齡、職業(yè)、文化水平、飲水來源等因素有關。多因素logistic回歸分析提示,職業(yè)、飲水來源、飯前洗手情況以及家中有胃癌或胃部疾病患者是Hp感染的危險因素。(2)武威市兒童及青少年Hp總感染率72.3%,各年齡組比較無統(tǒng)計學意義。x~2檢驗分析結(jié)果提示,Hp感染可能與居住地區(qū)、父母職業(yè)、飲水來源、是否上過幼兒園、是否生吃蔬菜、是否刷牙及母乳喂養(yǎng)有關。多因素logistic回歸分析提示,飲水來源、上過幼兒園、生吃蔬菜是Hp感染的危險因素。(3)Hp陽性標引者家中其他成員Hp感染率(82.3%)顯著高于Hp陰性標引者家中其他成員Hp感染率(47.4%),兩者差異有統(tǒng)計學意義(x~2=19.736 P＜0.05)。(4)根據(jù)臨床分型:Ⅰ型Hp感染57例(71.3%)Ⅱ型Hp感染23例(28.7%)。結(jié)論(1)武威市成人、兒童和青少年具有較高的Hp感染率,Hp感染可能存在人-人傳播和水源傳播途徑。(2)Hp感染存在家庭聚集現(xiàn)象。(3)武威市兒童及青少年Hp感染以Ⅰ型感染為主。
[Abstract]:Objective to investigate the prevalence of Helicobacter pylori (HP) infection in adults, children and adolescents in Wuwei City, Gansu Province, and to analyze the related factors of HP infection in order to provide a scientific basis for the prevention and treatment of Helicobacter pylori in this area. Methods from October 2007 to May 2008, HP infection was investigated in different population groups in Wuwei City. Elisa Elisa was used to detect HP infection rate in 797 adults from urban and rural residents in Wuwei City. A cross-sectional study of factors. (2) HP fecal antigen was detected in 938 children or adolescents aged 318 years and 96 families in Wuwei by Helicobacter pylori antigen detection method. HP virulence protein was analyzed by Helicobacter pylori Western blotting in 80 children or adolescents who were tested positive for HP fecal antigen. Standardized questionnaires were used to collect information on individual disease history, family disease history, risk factors and protective factors. Results 1) the infection rate of HP among adults in Wuwei was 81.8, and with the increase of age, the result of analysis of HP infection showed that HP infection might be related to age, occupation, education level, drinking water source and so on. Multivariate logistic regression analysis showed that occupation, drinking water source, Washing hands before meals and patients with gastric cancer or gastric diseases were the risk factors of HP infection.) the total HP infection rate of children and adolescents in Wuwei City was 72.3%. Parents occupation, drinking source, whether go to kindergarten, eat vegetables raw, brush teeth and breast-feed. Multivariate logistic regression analysis showed that drinking water source, went to kindergarten, Eating raw vegetables was the risk factor of HP infection. The HP infection rate of other members of the family was significantly higher than that of the other members of the HP negative group (P < 0.05. 4). The difference was statistically significant (P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05). There were 57 cases of type 鈪，

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