發(fā)布時間：2018-03-30 18:31

  本文選題：禽流感　切入點：職業(yè)暴露　出處：《山東醫(yī)藥》2017年34期

【摘要】：目的了解西寧市職業(yè)暴露人群高致病性禽流感病毒感染情況和環(huán)境中高致病性禽流感病毒污染狀況。方法 2012~2015年共采集職業(yè)暴露人群的血清標本485份,采用馬紅細胞血凝抑制實驗檢測H5N1、H7N9、H5N6禽流感抗體;在活禽市場采集環(huán)境標本879份,采用實時熒光定量反轉(zhuǎn)錄-聚合酶鏈反應法檢測禽流感病毒核酸Flu A,陽性標本進行H5、H7和H9亞型核酸檢測。結(jié)果職業(yè)暴露人群血清H5N1、H5N6和H7N9抗體檢測結(jié)果均為陰性。879環(huán)境份標本中檢出Flu A陽性159份(18.09%),其中2012~2015年Flu A陽性檢出率依次為9.55%、3.05%、20.82%、34.04%(P0.01);活禽零售市場Flu A陽性檢出率為25.24%,高于活禽批發(fā)市場的0.40%(P0.01)。Flu A陽性檢出率禽類新鮮糞便8.78%、禽類飲水26.67%、籠具表面19.87%、宰殺或者擺放禽類肉案板32.10%、清洗禽類的污水40.00%,不同種類標本檢出率存在統(tǒng)計學差異(P0.01);Flu A陽性標本亞型分析,僅H5陽性51例、僅H9陽性27例、H5和H9均陽性81例,未檢測到H7亞型。結(jié)論西寧市活禽交易市場中高致病性禽流感病毒陽性檢出率呈逐年增高趨勢,普遍存在著H5/H9雙重污染;西寧市職業(yè)暴露人群尚無人感染禽流感。
[Abstract]:Objective to investigate the infection of highly pathogenic avian influenza virus in occupational exposed population and the contamination of highly pathogenic avian influenza virus in the environment in Xining City. Methods 485 serum samples from occupational exposed population were collected from 2012 to 2015. Horse erythrocyte hemagglutination inhibition test was used to detect H5N1 N1H7N9H 5N6 avian influenza antibody, and 879 samples were collected from live poultry market. Flu A of avian influenza virus nucleic acid was detected by real-time fluorescence quantitative reverse transcription-polymerase chain reaction, and H5 H7 and H9 subtype nucleic acid were detected in positive samples. Results the results of detection of serum H5N1 N1H 5N6 and H7N9 antibody in occupational exposed population were negative. 879. 159 positive samples of Flu A were detected in environmental samples. The positive rate of Flu A in 2012-2015 was 9.55 / 3.05 and 20.82and 34.042 respectively (P 0.01), and the positive rate of Flu A in live poultry retail market was 25.24, which was higher than that in fresh poultry excrement 8.78% in live poultry wholesale market, and the positive rate of Flu A in poultry was 8.78%, and the positive rate of Flu A in poultry was 8.78% in poultry, and the positive rate of Flu A in live poultry retail market was 25.24%, higher than that in live poultry wholesale market. Drinking water 26.67, cage surface 19.87, slaughtering or placing poultry meat table 32.10, cleaning poultry sewage 40.00.There are statistical differences in the detection rate of different kinds of specimens. Only 51 cases were positive for H5, and 81 cases were positive for H5 and H9. No H7 subtype was detected. Conclusion the positive rate of H7 in the live poultry market of Xining is increasing year by year, and there is a double contamination of H5/H9. Xining City occupational exposure population has not been infected with avian influenza.
【作者單位】： 青海省疾病預防控制中心;
【基金】：國家重大科技專項傳染病監(jiān)測技術(shù)平臺(2012ZX10004-208)
【分類號】：R181.8;R511.7

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本文編號：1687109