本文選題：水痘　切入點(diǎn)：水痘疫苗　出處：《中國(guó)疫苗和免疫》2017年03期 　論文類型：期刊論文

【摘要】：目的了解濟(jì)南市歷城區(qū)1-12歲兒童水痘抗體水平,為完善水痘疫苗(VarV)免疫預(yù)防提供參考依據(jù)。方法2013年6-7月采取多階段隨機(jī)抽樣方法抽取城區(qū)、農(nóng)村山區(qū)、農(nóng)村平原6個(gè)村(居委會(huì))1-12歲健康兒童,采集血標(biāo)本,采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)檢測(cè)水痘Ig G抗體。結(jié)果共調(diào)查274名兒童,水痘抗體總陽性率為43.07%,幾何平均濃度(GMC)為82.28mIU/ml。在無VarV免疫史兒童中,平原地區(qū)、山區(qū)兒童水痘抗體陽性率分別為52.94%、22.06%(χ~2=12.17,P0.05),GMC分別為126.70 mIU/ml、38.36 mIU/ml(t=2.97,P0.05);1-6歲、7-12歲兒童水痘抗體陽性率分別為14.75%、54.44%(χ~2=24.21,P0.05),GMC分別為28.55mIU/ml、144.61mIU/ml(t=4.67,P0.05)。調(diào)查兒童水痘疫苗接種率為44.89%;有、無VarV接種史者抗體陽性率分別為46.55%、26.45%(χ~2=10.36,P0.05),GMC分別為85.27mIU/ml、44.68mIU/ml(t=0.61,P0.05)。接種首劑VarV后3-5年抗體陽性率和GMC最低(40.00%,74.76mIU/ml),但接種后不同年限之間均無顯著性差異。首劑VarV接種后抗體陰性兒童接種第2劑次后,抗體陽轉(zhuǎn)率為96.61%(57/59),GMC為397.53mIU/ml。結(jié)論濟(jì)南市歷城區(qū)1-12歲兒童VarV接種率、水痘抗體陽性率偏低,接種第2劑次后可顯著提高水痘抗體水平。應(yīng)在提高1劑次疫苗接種率基礎(chǔ)上,實(shí)施2劑次疫苗免疫策略。
[Abstract]:Objective to understand the level of chickenpox antibody in children aged 1-12 in Luicheng, Jinan, and to provide a reference for the improvement of varv immunization. Methods from June to July, 2013, a multi-stage random sampling method was used to select the chickenpox antibody from urban areas and rural mountainous areas. Blood samples were collected from 6 villages in rural plain (healthy children aged 1-12 years). Elisa Elisa was used to detect the IgG antibody of chickenpox. Results 274 children were investigated. The total positive rate of chickenpox antibody was 43.07 and the geometric mean concentration (GMC) was 82.28 m VarV / ml. In children with no history of VarV immunization, in plain areas, The positive rates of chickenpox antibodies in children of mountainous areas were 52.94 and 22.06 (蠂 2 / 12.17 / P 0.05 / GMC = 126.70 mIUml / r = 38.36 mIUml / ml / t 2.97% / 1 ~ 6 years old) respectively. The positive rates of chickenpox antibodies in children aged 1-6 years were 14.7554.444.44 (蠂 2 / 2 / 24.21P0.05 / GMC = 28.55 mIUml / r ~ 144.61mIUml / t 4.67mU / r = 4.67P0.05 respectively). The vaccination rate of chickenpox vaccine was 44.89%. The positive rates of antibody were 46.55% and 26.45% respectively (蠂 ~ (2) 10.36 ~ (6)) P 0.05 were 85.27 m / ml respectively. The positive rate of antibody in 3-5 years after inoculation with VarV and the lowest level of 40.0074.76 m / ml of GMC in children inoculated with the first dose of VarV were not significantly different between the years after inoculation and the second time after inoculation with the first dose of VarV, the results showed that there was no significant difference between the two groups in the three to five years after the inoculation of the first dose of VarV, the results showed that the positive rate of the antibody was not significantly different between the three to five years after the inoculation of the first dose of VarV and the lowest level of 40.0074.76 mm / ml of GMC. The positive rate of antibody was 96.61% 57 / 59 MMC was 397.53 mIUP 路ml.ConclusionThe positive rate of chickenpox antibody was lower in children aged 1-12 years old in Jinan city, and the level of varicella antibody could be significantly increased after inoculating the second dose of vaccine, and should be based on the increase of vaccination rate of 1 dose vaccine. Carry out 2 doses of vaccine immunization strategy.
【作者單位】： 濟(jì)南市歷城區(qū)疾病預(yù)防控制中心;山東省疾病預(yù)防控制中心;
【基金】：山東省科技發(fā)展計(jì)劃項(xiàng)目(編號(hào):2014GGH218019) 山東省泰山學(xué)者崗位支持項(xiàng)目
【分類號(hào)】：R186;R725.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 沈思翔,周柏林;兒童水痘致急性播散性腦脊髓炎一例[J];浙江大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2002年02期

2 王英;;中西醫(yī)結(jié)合治療兒童水痘療效觀察[J];山西中醫(yī);2012年03期

3 張宇;;兒童水痘用藥知多少[J];家庭醫(yī)學(xué)(下半月);2009年04期

4 劉燕華;冬季防治兒童水痘[J];醫(yī)藥世界;2000年01期

5 王志軍,錢穎,余琴;揚(yáng)州市廣陵區(qū)兒童水痘防治情況調(diào)查[J];江蘇預(yù)防醫(yī)學(xué);2002年02期

6 楊麗霞;;中西醫(yī)結(jié)合治療兒童水痘60例療效觀察[J];基層醫(yī)學(xué)論壇;2003年08期

7 黃禮蘭;鄭壽貴;鄭海鷗;王琴;姚慧晶;應(yīng)杰;;兒童水痘疫情控制常見問題與建議策略[J];中國(guó)預(yù)防醫(yī)學(xué)雜志;2007年06期

8 徐躍嶠;陳贊;;兒童水痘后并發(fā)急性硬脊膜外膿腫[J];臨床誤診誤治;2008年12期

9 屈寧寧;張峰;;兒童水痘35例臨床分析[J];山西醫(yī)藥雜志(下半月刊);2008年07期

10 劉桂芳;宋立志;馮蕾;李震;劉堯;張麗;張偉燕;呂靜靜;肖作奎;許青;徐愛強(qiáng);;山東省2007年≤14歲兒童水痘發(fā)病率抽樣調(diào)查[J];中國(guó)疫苗和免疫;2010年03期

相關(guān)會(huì)議論文 前1條

1 洪山;;阿昔洛韋治療兒童水痘42例療效觀察[A];第二十二屆航天醫(yī)學(xué)年會(huì)暨第五屆航天護(hù)理年會(huì)論文匯編（上冊(cè)）[C];2006年

，

本文編號(hào)：1638032