【摘要】：目的本研究利用自體濃縮生長因子(CGF)膜修復(fù)口腔黏膜組織缺損,觀察、探討其促進軟組織愈合、減少瘢痕的效果,評價CGF膜應(yīng)用于口腔黏膜組織缺損修復(fù)的臨床意義,并為口腔黏膜組織缺損的治療提供新的思路和方法。方法選擇并收集寧夏醫(yī)科大學總醫(yī)院口腔頜面外科病房2015年3月至2016年11月收治的因手術(shù)切除造成口腔黏膜組織缺損的患者,隨機分組,實驗組利用自體CGF膜修復(fù)缺損創(chuàng)面后碘仿紗條敷料反包扎固定;對照組直接運用碘仿紗條敷料反包扎覆蓋創(chuàng)面進行同期對照。隨訪術(shù)后1周、2周、3周、1月、2月、3月口腔黏膜缺損區(qū)生長情況,拍攝照片,運用Image-Pro Plus(IPP)圖像分析軟件計算缺損區(qū)域愈合面積率,記錄創(chuàng)面愈合時間,采用視覺模擬量表(VAS)測評患者的主觀感受,用溫哥華瘢痕量表(VSS)中文版測評術(shù)后3月瘢痕形成情況,并進行統(tǒng)計分析。結(jié)果自2015年3月至2016年11月收集的口腔黏膜組織缺損患者42例,失訪3例,39例納入研究,隨機分為實驗組19例,對照組20例。1.對實驗組與對照組術(shù)后2周、3周、1月時創(chuàng)面愈合率進行統(tǒng)計學分析,差異具有統(tǒng)計學意義。2.對實驗組與對照組術(shù)后1周、2周、3周、1月時VAS評分進行統(tǒng)計學分析,顯示均有統(tǒng)計學差異。3.對實驗組與對照組術(shù)后3月時VSS評分進行統(tǒng)計學分析,顯示差異具有統(tǒng)計學意義。結(jié)論1.CGF膜可以用于口腔黏膜組織缺損的修復(fù)。2.應(yīng)用CGF膜修復(fù)口腔黏膜組織缺損創(chuàng)面,可縮短創(chuàng)面愈合時間、減輕術(shù)后不適感、減少術(shù)后瘢痕的形成。3.CGF膜取自自體靜脈血,獲取方便快捷,適宜臨床推廣。
[Abstract]:Objective to observe the effect of autologous concentrated growth factor (CGF) membrane on repairing oral mucous membrane tissue defect, to explore the effect of promoting soft tissue healing and reducing scar, and to evaluate the clinical significance of CGF membrane in the repair of oral mucous membrane tissue defect. It also provides a new idea and method for the treatment of oral mucous membrane tissue defect. Methods from March 2015 to November 2016, patients with oral and maxillofacial defects caused by surgical resection were randomly divided into two groups. In the experimental group, iodoform gauze dressing was fixed with iodoform gauze dressing after repairing the defect wound with autologous CGF membrane. The control group was directly covered with iodoform gauze dressing for the same period. 1 week, 2 weeks, 3 weeks, 1 month, 2 months and 3 months after follow-up, the growth of oral mucous membrane defect area was taken, the healing area rate of defect area was calculated by Image-Pro Plus (IPP) image analysis software, and the wound healing time was recorded. The subjective feelings of the patients were measured by visual simulation scale (VAS), and the scar formation was evaluated by Vancouver scar scale (VSS) in Chinese version, and the statistical analysis was carried out. Results from March 2015 to November 2016, 42 patients with oral mucosal tissue defect were collected, 3 of them lost follow-up, and 39 of them were included in the study. They were randomly divided into experimental group (n = 19) and control group (n = 20). The wound healing rate of the experimental group and the control group at 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and the difference was statistically significant. 2. The VAS scores of the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and there was significant difference between the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation. The VSS score of the experimental group and the control group at 3 months after operation was statistically analyzed, and the difference was statistically significant. Conclusion 1.CGF membrane can be used to repair oral mucous membrane defects. 2. The application of CGF membrane to repair oral mucous membrane defect can shorten the wound healing time, reduce the discomfort after operation and reduce the formation of scar after operation. 3. CGF membrane is taken from autologous venous blood, which is convenient and rapid, and is suitable for clinical promotion.
【學位授予單位】：寧夏醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R782

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