發(fā)布時(shí)間：2019-03-26 12:35

【摘要】：目的探討分化抑制蛋白-1(Id-1)和基質(zhì)金屬蛋白酶2(MMP-2)在涎腺腺樣囊性癌(SACC)中的表達(dá)及其與腫瘤侵襲和轉(zhuǎn)移的相關(guān)性。方法用免疫組織化學(xué)方法檢測(cè)Id-1和MMP-2在60例SACC組織(實(shí)驗(yàn)組)與60例癌旁正常組織(對(duì)照組)中的表達(dá)情況,分析二者的表達(dá)與SACC浸潤(rùn)和侵襲的相關(guān)性。結(jié)果實(shí)驗(yàn)組和對(duì)照組的Id-蛋白陽(yáng)性表達(dá)率分別為68.33%(41/60例)和13.33%(8/60例);MMP-2蛋白陽(yáng)性表達(dá)率分別為73.33%(44/60例)和18.33%(11/60例),差異有統(tǒng)計(jì)學(xué)意義(P0.001)。Id-1和MMP-2的陽(yáng)性表達(dá)率在有淋巴結(jié)轉(zhuǎn)移者分別為83.33%,87.50%、在無(wú)淋巴結(jié)轉(zhuǎn)移者分別為58.33%,63.90%;在肺轉(zhuǎn)移者分別為88.24%,94.12%、在無(wú)肺轉(zhuǎn)移者分別為60.47%,65.12%;在Ⅲ+Ⅳ期者分別為81.48%,88.89%、在Ⅰ+Ⅱ期者分別為57.58%,60.61%;在中/低分化者分別為85.71%,91.42%、在高分化者分別為44.00%,48.00%;在伴脈管浸潤(rùn)者分別為89.47%,100.00%、無(wú)脈管浸潤(rùn)者分別為58.54%,60.98%;且Id-1和MMP-2在上述前者的陽(yáng)性表達(dá)率明顯高于后者,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。Id-1和MMP-2的陽(yáng)性表達(dá)率在男性分別為66.67%,75.00%、在女性分別為70.83%,70.83%;在≥50歲者分別為73.53%,76.47%、在50歲者分別為61.54%,69.23%;在小涎腺者分別為63.64%,72.73%、在大涎腺者分別為71.05%,73.68%;且Id-1和MMP-2在上述前者和后者的陽(yáng)性表達(dá)率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。Id-1和MMP-2在SACC中的表達(dá)呈正相關(guān)。結(jié)論 Id-1和MMP-2的異常表達(dá)在SACC發(fā)展、浸潤(rùn)過(guò)程中起重要作用,聯(lián)合檢測(cè)Id-1和MMP-2的表達(dá)水平有可能作為監(jiān)測(cè)SACC進(jìn)展和轉(zhuǎn)移的生物學(xué)指標(biāo)。
[Abstract]:Aim to investigate the expression of inhibitor of differentiation protein-1 (Id-1) and matrix metalloproteinase-2 (MMP-2) in salivary adenoid cystic carcinoma (SACC) and their correlation with invasion and metastasis. Methods Immunohistochemistry was used to detect the expression of Id-1 and MMP-2 in 60 cases of SACC tissues (experimental group) and 60 cases of normal tissues adjacent to carcinoma (control group). The correlation between the expression of SACC and the invasion and invasion of SACC was analyzed. Results the positive expression rates of Id- protein in experimental group and control group were 68.33% (41 / 60) and 13.33% (8 / 60), respectively. The positive expression rates of MMP-2 protein were 73.33% (44 / 60) and 18.33% (11 / 60), respectively. The positive expression rates of Id-1 and MMP-2 were 83.33%, 87.50% and 58.33%, 63.90% in the patients with lymph node metastasis, and those without lymph node metastasis, respectively (P0.001). The rates of lung metastasis were 88.24%, 94.12%, 60.47%, 65.12%, 81.48%, 88.89%, 57.58%, 60.61% in stage 鈪，

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