發(fā)布時間：2018-12-17 18:42

【摘要】：目的:萎縮性舌炎為口腔黏膜常見疾病之一,病因復(fù)雜。本研究通過收集臨床病例資料,分析相關(guān)數(shù)據(jù),探索萎縮性舌炎與貧血相關(guān)因子(血常規(guī)、血清維生素B12、血清鐵蛋白、葉酸)的關(guān)系,以指導(dǎo)臨床診斷與治療。方法:收集2015年4月至2016年12月于青島大學(xué)附屬醫(yī)院口腔黏膜科主治及以上醫(yī)師診斷為萎縮性舌炎的臨床病例共33例。排除舌部念珠菌鏡檢陽性患者,近期服用維生素、抗生素或含鐵藥物患者,干燥綜合征患者及舌背黏膜出現(xiàn)萎縮性改變的其他疾病(如地圖舌、口腔扁平苔蘚、正中菱形舌、放射性口炎等)的患者。檢測萎縮性舌炎患者的血常規(guī)、血清維生素B12、血清鐵蛋白及葉酸水平。對數(shù)據(jù)進(jìn)行統(tǒng)計分析,采用百分率來表示各數(shù)據(jù)之間的大小關(guān)系。探索萎縮性舌炎與貧血相關(guān)因子的關(guān)系。結(jié)果:33例萎縮性舌炎患者中,男女比例為1:4.5,最低年齡32歲,最高年齡80歲,平均年齡57.9歲,50-60歲有12人,60-70歲有10人,共計22人,占66.67%;33例萎縮性舌炎患者中,血紅蛋白、紅細(xì)胞計數(shù)、紅細(xì)胞比容指標(biāo)出現(xiàn)異常者共計19人,占57.58%;33例萎縮性舌炎患者中,維生素B12缺乏16人次,占48.5%,血清鐵蛋白缺乏10人次,占30.3%,其中維生素B12、血清鐵蛋白均缺乏4例,占12.12%;33例萎縮性舌炎患者葉酸水平均正常;7例大細(xì)胞性貧血患者均有維生素B12缺乏,4例小細(xì)胞低色素性貧血患者均有血清鐵蛋白缺乏;14例血常規(guī)正常的萎縮性舌炎患者中,有5例出現(xiàn)維生素B12或血清鐵蛋白降低。結(jié)論:排除感染因素及其他因素,萎縮性舌炎好發(fā)于中老年女性,其發(fā)生與貧血相關(guān)因子有關(guān);在異常的貧血相關(guān)因子中,血清維生素B12缺乏比例占第一位,其次為血清鐵蛋白缺乏;本研究未發(fā)現(xiàn)萎縮性舌炎的發(fā)生與葉酸缺乏有關(guān);維生素B12缺乏或血清鐵蛋白缺乏引起的舌乳頭萎縮可能會早于血常規(guī)指標(biāo)的改變。
[Abstract]:Objective: atrophic glossitis is one of the common diseases of oral mucosa. In order to guide clinical diagnosis and treatment, this study investigated the relationship between atrophic glossitis and anemia related factors (blood routine, serum vitamin B12, serum ferritin, folic acid) by collecting clinical data and analyzing relevant data. Methods: from April 2015 to December 2016, 33 patients with atrophic glossitis diagnosed by oral mucosal department or above in the affiliated Hospital of Qingdao University were collected. Other diseases such as map tongue, oral lichen planus, median rhomboid tongue, and other diseases (map tongue, oral lichen planus, median rhomboid tongue), patients with Sjogren's syndrome and atrophic changes in the dorsal mucosa of the tongue are excluded. A patient with radiation stomatitis, etc. The blood routine, serum vitamin B 12, serum ferritin and folic acid levels were measured in patients with atrophic glossitis. Statistical analysis of the data, the use of percentages to represent the size of the relationship between the data. To explore the relationship between atrophic glossitis and anemia related factors. Results: among 33 patients with atrophic glossitis, the ratio of male to female was 1: 4.5, the minimum age was 32 years old, the highest age was 80 years old, the average age was 57.9 years old, there were 12 patients aged 50-60 years and 10 patients aged 60-70 years. In 33 patients with atrophic glossitis, 19 patients (57.58) had abnormal hemoglobin, erythrocyte count and erythrocyte specific volume index. In 33 patients with atrophic glossitis, there were 16 cases of vitamin B12 deficiency (48.5%), 10 cases of serum ferritin deficiency (30.3%), and 4 cases of vitamin B12 and serum ferritin deficiency (12.12%). The levels of folic acid were normal in 33 patients with atrophic glossitis, vitamin B12 deficiency was found in 7 patients with macrocytic anemia and serum ferritin deficiency in 4 patients with small cell hypochromic anemia. Of 14 patients with atrophic glossitis with normal blood routine, 5 had vitamin B 12 or decreased serum ferritin. Conclusion: the incidence of atrophic glossitis in middle-aged and elderly women is related to anemia related factors, excluding infection factors and other factors. Among the abnormal anemia related factors, the proportion of serum vitamin B12 deficiency was the first, followed by the serum ferritin deficiency, and there was no relationship between the occurrence of atrophic glossitis and folic acid deficiency in this study. Tongue papilla atrophy caused by vitamin B 12 deficiency or serum ferritin deficiency may be earlier than the change of blood routine.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R556;R781.57

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 畢順芬;;金因肽治療復(fù)發(fā)性口腔潰瘍的臨床療效[J];中國社區(qū)醫(yī)師;2016年24期

2 周穎杰;李光輝;;2009年美國感染病學(xué)會念珠菌病處理指南解讀[J];中國循證醫(yī)學(xué)雜志;2016年01期

3 荊徐波;田正良;;沙參麥冬湯加減治療慢性貧血相關(guān)萎縮性舌炎30例[J];實用中醫(yī)藥雜志;2015年12期

4 劉志明;張虹;毛甜甜;張周文;彭友儉;;不同藥物治療復(fù)發(fā)性口腔潰瘍效用的回顧性分析[J];檢驗醫(yī)學(xué)與臨床;2015年21期

5 戴麗霞;劉虎;趙榮;;顯微超聲技術(shù)結(jié)合CBCT在上頜第一磨牙MB2根管再治療中的應(yīng)用[J];臨床口腔醫(yī)學(xué)雜志;2015年09期

6 張軍華;;一次性與多次根管治療急性牙髓炎療效觀察[J];中華實用診斷與治療雜志;2015年09期

7 曾曉燕;周維;張波;;碳酸氫鈉液含漱預(yù)防放療患者口腔真菌感染的效果研究[J];中華醫(yī)院感染學(xué)雜志;2015年17期

8 崔鳶;代青蕓;馮慧;江潞;;萎縮性舌炎病因的研究進(jìn)展[J];國際口腔醫(yī)學(xué)雜志;2015年04期

9 魯宇;;144例機(jī)用鎳鈦器械進(jìn)行根管預(yù)備的臨床觀察[J];世界最新醫(yī)學(xué)信息文摘;2015年47期

10 陳小賢;林碧琛;鐘潔;葛立宏;;改良乳牙根管充填材料體內(nèi)降解匹配性與臨床效果[J];北京大學(xué)學(xué)報(醫(yī)學(xué)版);2015年03期

相關(guān)碩士學(xué)位論文 前2條

1 張麗;萎縮性舌炎與缺鐵性貧血、念珠菌感染的相關(guān)性研究[D];瀘州醫(yī)學(xué)院;2014年

2 尹苓;二甲雙胍對血清維生素B12水平及糖尿病周圍神經(jīng)病變的影響[D];山東大學(xué);2010年

，

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