【摘要】：背景:目前國內(nèi)外臨床上治療牙髓壞死而根尖未發(fā)育完全年輕恒牙的傳統(tǒng)手段主要是"根尖誘導成形術(shù)"以及近些年發(fā)展起來的"MTA根尖屏障術(shù)",但這兩種方法均不能使根管長度增加和根管壁增厚。那么是否有一種方法能夠讓患者利用自身的潛能,促進患牙牙根的進一步發(fā)育呢?牙髓血管再生術(shù)的出現(xiàn)帶來了曙光,但目前臨床上牙髓血管再生術(shù)成功的幾乎都是個例。目的:印證牙髓血管再生術(shù)用于臨床治療因齲病、牙體發(fā)育異常、外傷導致年輕恒牙牙髓壞死、牙根發(fā)育停滯的療效,為其在臨床上大規(guī)模應(yīng)用提供經(jīng)驗和證據(jù)。方法:試驗為前瞻性單中心隨機對照臨床試驗,在中國陜西省,西安交通大學附屬口腔醫(yī)院牙體牙髓科完成。選擇2013年12月至2016年12月收治,牙髓壞死或根尖周炎根尖未發(fā)育完全的年輕恒牙患者82例82顆患牙,隨機分為2組,試驗組41例采用牙髓血管再生術(shù)治療,對照組41例采用根尖誘導成形術(shù)治療。治療后3,6,9,12,18個月復診,通過臨床檢查和X射線片評價療效,觀察兩組患牙牙髓活力及牙根發(fā)育情況。試驗方案經(jīng)西安交通大學附屬口腔醫(yī)院倫理委員會批準,批準號為JDKY015-02。臨床試驗研究的實施符合《赫爾辛基宣言》和醫(yī)院對人體研究的相關(guān)倫理要求。參與試驗的患病個體及其監(jiān)護人為自愿參加,均對試驗過程完全知情同意,在充分了解治療方案的前提下簽署"知情同意書"。結(jié)果與結(jié)論:截止2017年3月25日,患者已經(jīng)隨訪6.5-18個月。試驗組治療成功率97.6%,高于對照組82.9%(P0.05);試驗組的牙髓活力陽性率24.4%,高于對照組0(P0.05);試驗組的牙根繼續(xù)發(fā)育所占比例為63.4%,對照組為29.3%,試驗組高于對照組(P0.05)。說明與根尖誘導成形術(shù)相比,采用牙髓血管再生術(shù)治療牙髓壞死而根尖未發(fā)育完全的年輕恒牙可以取得較高的成功率,并可促使牙根繼續(xù)發(fā)育。
[Abstract]:Background: at present, the traditional treatment of endodontic necrosis and immature young permanent teeth at home and abroad is mainly "apical induction plasty" and "MTA apical barrier surgery" developed in recent years. But neither of these two methods can increase the length of root canal and the thickness of root canal wall. So is there a way for patients to use their potential to promote the further development of the root of the affected teeth? The appearance of dental pulp angiogenesis has brought dawn, but the clinical success of dental pulp angiogenesis is almost unique. Objective: to confirm the efficacy of dental pulp angiogenesis in the treatment of young permanent teeth with pulp necrosis and root development stagnation due to dental caries, abnormal tooth development and trauma, and to provide experience and evidence for its large-scale clinical application. Methods: a prospective single center randomized controlled clinical trial was carried out in the dental pulp department of Xi'an Jiaotong University Stomatology Hospital, Shaanxi Province, China. From December 2013 to December 2016, 82 young permanent teeth with necrotic pulp or incomplete apical periodontitis were selected and randomly divided into two groups. The experimental group (n = 41) was treated with pulp vascular regeneration. 41 cases in the control group were treated with apical-induced angioplasty. The pulp vigor and root development of the two groups were observed by clinical examination and X-ray radiography. The pilot scheme was approved by the Ethics Committee of Stomatology Hospital affiliated to Xi'an Jiaotong University under the name JDKY015-02. The implementation of clinical trial research is in line with the Helsinki Declaration and the ethical requirements of human research in hospitals. The patients and their guardians took part in the trial voluntarily and signed the "informed consent" on the premise of full understanding of the treatment plan. Results and conclusions: as of March 25, 2017, the patient had been followed up for 6. 5-18 months. The successful rate of treatment in the test group was 97.6, which was higher than that in the control group (82.9%, P0.05), and the positive rate of pulp activity in the experimental group was 24.4%, which was higher than that in the control group (0%, P0.05). The proportion of root development was 63.4 in the experimental group and 29.3in the control group, which was higher in the experimental group than in the control group (P0.05). Compared with apical induced angioplasty, the treatment of pulp necrosis with incomplete apical development of young permanent teeth can achieve a higher success rate and promote the development of root.
【作者單位】： 西安交通大學附屬口腔醫(yī)院第一門診;
【基金】：陜西省衛(wèi)計委科研項目(SWJ2016QN013)~~
【分類號】：R781.05

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