選擇性激光熔覆制備微孔鈦試件及體內(nèi)實驗研究
發(fā)布時間：2018-10-07 18:21
【摘要】：目的評估選擇性激光熔覆(SLM)成形微孔鈦結(jié)構(gòu)對材料生物活性的影響。方法以0~45μm的球形二級鈦粉為實驗原料,平鋪在5 cm×5 cm×0.5 cm的純鈦基板上,在合適的激光參數(shù)條件下,制備出孔徑范圍在150~200μm及200~250μm的兩組試件。以大顆粒噴砂酸蝕(SLA)工藝處理的試件為對照,通過動物實驗研究,評價材料生物活性。結(jié)果場發(fā)射掃描電鏡觀察不同試件表面微孔結(jié)構(gòu),EDS顯示SLA組表面C元素高于SLM組(P=0.037);SLM組試件彈性模量明顯降低,接近于人類骨皮質(zhì)(P0.05);孔徑200~250μm試件骨結(jié)合率在第8周差異有統(tǒng)計學(xué)意義(P=0.028)。結(jié)論微孔結(jié)構(gòu)能有效降低試件表面的彈性模量,且孔徑范圍200~250μm的試件在中期誘導(dǎo)骨形成的能力上更加顯著。
[Abstract]:Objective to evaluate the effect of selective laser cladding (SLM) on the bioactivity of microporous titanium. Methods the spherical secondary titanium powder of 0 ~ 45 渭 m was used as the experimental material, and two kinds of samples with pore diameter of 150 ~ 200 渭 m and 200 ~ 250 渭 m were prepared on 5 cm 脳 5 cm 脳 0.5 cm pure titanium substrate under suitable laser parameters. The biological activity of the material was evaluated by animal experiment with the large particle blast acid etching (SLA) process as control. Results Field emission scanning electron microscopy (SEM) showed that the surface C element in SLA group was significantly lower than that in SLM group (P0. 037). It was close to the human bone cortex (P0.05), and the osseous binding rate of the 200m 250 渭 m specimen was significantly different from that of the human bone cortex at the 8th week (P0. 028). Conclusion the micropore structure can effectively reduce the elastic modulus of the specimen surface, and the ability of inducing bone formation in the medium term of the specimen with the pore diameter of 200 ~ 250 渭 m is more remarkable.
【作者單位】： 安徽醫(yī)科大學(xué)第二附屬醫(yī)院口腔科;安徽醫(yī)學(xué)高等�？茖W(xué)校口腔系;
【基金】：安徽省自然科學(xué)基金(編號:1508085MH156) 安徽省學(xué)術(shù)和技術(shù)帶頭人科研活動經(jīng)費資助項目(編號:2014H030)
【分類號】：R783.1
本文編號：2255207
[Abstract]:Objective to evaluate the effect of selective laser cladding (SLM) on the bioactivity of microporous titanium. Methods the spherical secondary titanium powder of 0 ~ 45 渭 m was used as the experimental material, and two kinds of samples with pore diameter of 150 ~ 200 渭 m and 200 ~ 250 渭 m were prepared on 5 cm 脳 5 cm 脳 0.5 cm pure titanium substrate under suitable laser parameters. The biological activity of the material was evaluated by animal experiment with the large particle blast acid etching (SLA) process as control. Results Field emission scanning electron microscopy (SEM) showed that the surface C element in SLA group was significantly lower than that in SLM group (P0. 037). It was close to the human bone cortex (P0.05), and the osseous binding rate of the 200m 250 渭 m specimen was significantly different from that of the human bone cortex at the 8th week (P0. 028). Conclusion the micropore structure can effectively reduce the elastic modulus of the specimen surface, and the ability of inducing bone formation in the medium term of the specimen with the pore diameter of 200 ~ 250 渭 m is more remarkable.
【作者單位】： 安徽醫(yī)科大學(xué)第二附屬醫(yī)院口腔科;安徽醫(yī)學(xué)高等�？茖W(xué)校口腔系;
【基金】：安徽省自然科學(xué)基金(編號:1508085MH156) 安徽省學(xué)術(shù)和技術(shù)帶頭人科研活動經(jīng)費資助項目(編號:2014H030)
【分類號】：R783.1
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