關(guān)于初期穩(wěn)定性對(duì)即刻種植成功率影響的動(dòng)物實(shí)驗(yàn)研究
發(fā)布時(shí)間：2018-09-18 14:09
【摘要】：目的：從實(shí)驗(yàn)的角度觀察初期穩(wěn)定性對(duì)HA涂層、軟組織水平、根形植體即刻種植成功率的影響,以期為臨床手術(shù)中的操作提供理論依據(jù)。 方法： 1、建立動(dòng)物模型： 四只成年雜種狗雙側(cè)下頜后牙區(qū)四個(gè)種植位點(diǎn)隨機(jī)分為兩組：實(shí)驗(yàn)組和對(duì)照組。實(shí)驗(yàn)組：差級(jí)備孔后植入BLB植體(北京萊頓生物材料有限公司),控制其ISQ值小于50,植入力矩值小于20N；對(duì)照組：精確備孔后植入BLB植體,控制其ISQ值大于65,植入力矩值大于30N。在植入當(dāng)時(shí)及第四周、八周、十二周測(cè)量植體ISQ值并記錄；同期拍攝狗顱腦CT并觀察種植體周圍骨密度。 2、術(shù)后第十二周處死實(shí)驗(yàn)動(dòng)物 (1)肉眼觀察：種植體周圍情況 (2)光鏡下觀察：在種植位點(diǎn)取2.5x1.5xl cm3骨標(biāo)本(包含種植體)共十六個(gè)做硬組織切片后進(jìn)行甲苯胺藍(lán)染色(或伊紅美蘭染色)。光學(xué)顯微鏡下觀察骨密度并計(jì)算種植體—骨結(jié)合率(圖1)。 3、統(tǒng)計(jì)學(xué)分析：各組數(shù)據(jù)行正態(tài)性檢驗(yàn),若數(shù)據(jù)為正態(tài)分布,則行方差齊性檢驗(yàn)和t檢驗(yàn)；若數(shù)據(jù)不為正態(tài)分布,則行wilcoxon秩和檢驗(yàn)。 結(jié)果： 1、大體標(biāo)本觀察：所有種植體均無(wú)松動(dòng)、脫落現(xiàn)象；種植體周圍局部粘膜健康,未發(fā)現(xiàn)充血、腫脹等炎性癥狀。用金屬桿輕輕敲打種植體,敲擊聲音清脆,表示已種植成功。 2、影像學(xué)檢查：植入當(dāng)天CT顯示示對(duì)照組與實(shí)驗(yàn)組種植體周圍骨密度有顯著差異(圖2)；植入后第四周CT顯示對(duì)照組與實(shí)驗(yàn)組種植體周圍骨密度無(wú)顯著差異(圖3)；植入后第八周CT顯示對(duì)照組與實(shí)驗(yàn)組種植體骨密度無(wú)顯著差異(圖4)。植入后第十二周CT顯示對(duì)照組與實(shí)驗(yàn)組種植體骨密度無(wú)顯著差異。 3、組織學(xué)檢查：甲苯胺藍(lán)染色后,見(jiàn)即刻拔牙后遺留空腔大部分已有新生骨長(zhǎng)入,可見(jiàn)明顯的哈佛氏系統(tǒng)(圖5)。新生的編織骨延種植體表面螺紋蔓延沉積(圖6),種植體與牙槽骨為骨性結(jié)合,可見(jiàn)成骨細(xì)胞零星排列,散落分布(圖7)。種植體與牙槽骨之間的結(jié)合呈間斷性,大部分切片顯示種植體底部與牙槽骨之間有空腔。在少數(shù)種植體螺紋邊緣未有骨結(jié)合處,伊紅美蘭染色中發(fā)現(xiàn)有未及骨化的纖維組織(圖8)。 4、統(tǒng)計(jì)學(xué)分析：各組數(shù)據(jù)行正態(tài)性檢驗(yàn)和方差齊性檢驗(yàn),確定各組數(shù)據(jù)均為正態(tài)分布、方差齊性,行方差分析P0.05,差異無(wú)統(tǒng)計(jì)學(xué)意義,可認(rèn)為兩組間利,植體—骨結(jié)合率無(wú)區(qū)別。 結(jié)論：即刻種植BLB植體初期的ISQ值在28到49區(qū)間及68至75區(qū)間,對(duì)應(yīng)植入力矩值在10-20N以內(nèi)及30N以上,其成功率無(wú)顯著差別。
[Abstract]:Objective: to observe the effect of initial stability on HA coating, soft tissue level and immediate implant success rate in order to provide theoretical basis for clinical operation. Methods: 1. Establish animal model: four adult mongrel dogs were randomly divided into two groups: experimental group and control group. Experimental group: BLB implant (Beijing Leiden Biomaterials Co., Ltd.) was implanted after the preparation of the hole, the ISQ value was less than 50, and the implant torque value was less than 20N. in the control group, the BLB implant was implanted after accurate preparation, the ISQ value was more than 65, and the implant torque value was more than 30N. At the time of implantation and four weeks, eight weeks and twelve weeks, the ISQ values of the implant were measured and recorded. At the same time, CT was photographed and bone mineral density around implant was observed. 2. 12 weeks after operation, experimental animals were killed (1) naked eye observation: (2) condition around implant (2) under light microscope: under implantation Sixteen 2.5x1.5xl cm3 bone specimens (including implants) were taken for hard tissue sections and stained with toluidine blue (or erethromethylene blue staining). Bone mineral density (BMD) was observed under optical microscope and implant-bone bonding rate (Fig. 1) was calculated (Fig. 1). Statistical analysis: the data of each group were examined by normality test, and if the data were normal distribution, homogeneity test of variance and t test were performed. If the data is not normal distribution, the wilcoxon rank sum test is performed. Results: 1. Gross observation: no loosening and abscission were observed in all implants and no inflammatory symptoms such as congestion and swelling were found in the local mucosa around the implants. The implants were lightly struck with metal rods, and the sound was clear and crisp, indicating that the implant had been successfully planted. 2. Imaging examination: on the day of implantation, CT showed that there was a significant difference in bone mineral density between the control group and the experimental group (Fig. 2); There was no significant difference in bone mineral density between the control group and the experimental group by CT at the 4th week after implantation (Fig.3), but by CT at the 8th week after implantation, there was no significant difference in BMD between the control group and the experimental group (Fig. 4). CT showed that there was no significant difference in bone density between the control group and the experimental group 12 weeks after implantation. An obvious Harvard system can be seen (Fig. 5). The newly formed braided bone extended the surface of the implant (Fig. 6), the implant and alveolar bone were osseous, osteoblasts were scattered and scattered (Fig. 7). The bonding between implant and alveolar bone was intermittent, and most sections showed that there was a cavity between the implant bottom and alveolar bone. Unossified fibrous tissue was found in a few implants with unossified fibrous tissue at the edge of the implant thread (Fig. 8). 4. Statistical analysis: the data of each group were tested for normality and homogeneity of variance. The data of each group were all normal distribution, homogeneity of variance, analysis of variance (P0.05), the difference was not statistically significant, it can be considered that there is no difference between the two groups, the implant and bone bonding rate. Conclusion: the initial ISQ values of immediate BLB implants are between 28 to 49 and 68 to 75, and the corresponding implant torque values are within 10 ~ 20 N and more than 30 N, and there is no significant difference in the success rate.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R783.6
本文編號(hào)：2248156
[Abstract]:Objective: to observe the effect of initial stability on HA coating, soft tissue level and immediate implant success rate in order to provide theoretical basis for clinical operation. Methods: 1. Establish animal model: four adult mongrel dogs were randomly divided into two groups: experimental group and control group. Experimental group: BLB implant (Beijing Leiden Biomaterials Co., Ltd.) was implanted after the preparation of the hole, the ISQ value was less than 50, and the implant torque value was less than 20N. in the control group, the BLB implant was implanted after accurate preparation, the ISQ value was more than 65, and the implant torque value was more than 30N. At the time of implantation and four weeks, eight weeks and twelve weeks, the ISQ values of the implant were measured and recorded. At the same time, CT was photographed and bone mineral density around implant was observed. 2. 12 weeks after operation, experimental animals were killed (1) naked eye observation: (2) condition around implant (2) under light microscope: under implantation Sixteen 2.5x1.5xl cm3 bone specimens (including implants) were taken for hard tissue sections and stained with toluidine blue (or erethromethylene blue staining). Bone mineral density (BMD) was observed under optical microscope and implant-bone bonding rate (Fig. 1) was calculated (Fig. 1). Statistical analysis: the data of each group were examined by normality test, and if the data were normal distribution, homogeneity test of variance and t test were performed. If the data is not normal distribution, the wilcoxon rank sum test is performed. Results: 1. Gross observation: no loosening and abscission were observed in all implants and no inflammatory symptoms such as congestion and swelling were found in the local mucosa around the implants. The implants were lightly struck with metal rods, and the sound was clear and crisp, indicating that the implant had been successfully planted. 2. Imaging examination: on the day of implantation, CT showed that there was a significant difference in bone mineral density between the control group and the experimental group (Fig. 2); There was no significant difference in bone mineral density between the control group and the experimental group by CT at the 4th week after implantation (Fig.3), but by CT at the 8th week after implantation, there was no significant difference in BMD between the control group and the experimental group (Fig. 4). CT showed that there was no significant difference in bone density between the control group and the experimental group 12 weeks after implantation. An obvious Harvard system can be seen (Fig. 5). The newly formed braided bone extended the surface of the implant (Fig. 6), the implant and alveolar bone were osseous, osteoblasts were scattered and scattered (Fig. 7). The bonding between implant and alveolar bone was intermittent, and most sections showed that there was a cavity between the implant bottom and alveolar bone. Unossified fibrous tissue was found in a few implants with unossified fibrous tissue at the edge of the implant thread (Fig. 8). 4. Statistical analysis: the data of each group were tested for normality and homogeneity of variance. The data of each group were all normal distribution, homogeneity of variance, analysis of variance (P0.05), the difference was not statistically significant, it can be considered that there is no difference between the two groups, the implant and bone bonding rate. Conclusion: the initial ISQ values of immediate BLB implants are between 28 to 49 and 68 to 75, and the corresponding implant torque values are within 10 ~ 20 N and more than 30 N, and there is no significant difference in the success rate.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R783.6
【參考文獻(xiàn)】
相關(guān)期刊論文 前4條
1 戴巧群;林映荷;;即刻負(fù)荷種植體初期穩(wěn)定性的測(cè)量及影響因素[J];廣東牙病防治;2007年12期
2 伍穎穎;宮蘋(píng);;種植體初期穩(wěn)定性的研究現(xiàn)狀與進(jìn)展[J];國(guó)際口腔醫(yī)學(xué)雜志;2009年06期
3 黃建生,周磊,宋光保;后牙區(qū)即刻種植的臨床研究[J];現(xiàn)代口腔醫(yī)學(xué)雜志;2004年03期
4 蘇波,張惠蘭;即刻種植義齒[J];中華老年口腔醫(yī)學(xué)雜志;2004年04期
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