【摘要】：目的:分析先天缺牙和唇/腭裂綜合征相關(guān)蛋白--TP63蛋白的相互作用分子,并對其生物學(xué)功能進(jìn)行分析。方法:利用生物信息學(xué)數(shù)據(jù)庫(STRING)分析和預(yù)測TP63蛋白的相互作用蛋白。在DAVID數(shù)據(jù)庫對相互作用蛋白的生物學(xué)功能進(jìn)行分析。結(jié)果:對STRING數(shù)據(jù)庫預(yù)測的TP63蛋白50個(gè)相互作用蛋白的生物學(xué)功能分析顯示,TP63相互作用分子主要參與對細(xì)胞增殖和凋亡的調(diào)節(jié)。結(jié)論:生物信息學(xué)分析初步揭示了TP63蛋白的相互作用網(wǎng)絡(luò)及其生物學(xué)功能。
[Abstract]:Aim: to analyze the interaction molecules of TP63 protein associated with congenital tooth deficiency and lip / cleft palate syndrome, and to analyze its biological function. Methods: the interaction protein of TP63 protein was analyzed and predicted by bioinformatics database (STRING). The biological function of interacting proteins was analyzed in DAVID database. Results: the biological function analysis of 50 interaction proteins of TP63 protein predicted by STRING database showed that TP63 interaction molecules were mainly involved in the regulation of cell proliferation and apoptosis. Conclusion: bioinformatics analysis revealed the interaction network and biological function of TP63 protein.
【作者單位】： 湖北醫(yī)藥學(xué)院附屬隨州醫(yī)院.隨州市中心醫(yī)院口腔科;武漢大學(xué)口腔醫(yī)學(xué)院湖北省口腔基礎(chǔ)醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室-省部共建國家重點(diǎn)實(shí)驗(yàn)室培育基地;
【基金】：國家自然科學(xué)基金(編號:81470727;81501750) 湖北省口腔基礎(chǔ)醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室-省部共建國家重點(diǎn)實(shí)驗(yàn)室培育基地開放研究基金(編號:201402)
【分類號】：R782.2
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本文編號：2202052