【摘要】：現(xiàn)代醫(yī)學(xué)已從"以疾病為導(dǎo)向"轉(zhuǎn)至"以患者為導(dǎo)向",開啟了以個體化醫(yī)療為目標(biāo)的精準(zhǔn)醫(yī)療時代。人體的生理功能不但由自身基因組決定,還受共生菌群即人類微生物組的塑造與影響。目前,人類微生物組的研究已經(jīng)超越了簡單解析組成成員與疾病之間的相關(guān)性,開始深入分析其對復(fù)雜疾病發(fā)病、診斷及治療的貢獻,這些突破性研究成果有望成為推動個性化精準(zhǔn)醫(yī)療的重要助力。本文著重介紹口腔微生物組的最新研究進展、口腔微生物組在疾病早期風(fēng)險預(yù)警、早期診斷、治療及療效評估等方面的探索性運用,討論了口腔微生物組在精準(zhǔn)醫(yī)療發(fā)展中的潛力,以及整合口腔微生物組信息,實現(xiàn)精準(zhǔn)醫(yī)療所面臨的重大挑戰(zhàn)。
[Abstract]:Modern medicine has changed from "disease-oriented" to "patient-oriented", opening the era of individualized medicine. The physiological function of human body is determined not only by its own genome, but also by the creation and influence of symbiotic microflora. At present, the study of human microbial group has gone beyond the simple analysis of the relationship between the constituent members and the disease, and has begun to analyze in depth its contribution to the pathogenesis, diagnosis and treatment of complex diseases. These breakthrough research results are expected to be an important aid to promote personalized precision medicine. This article focuses on the latest research progress in oral microbiology, the exploratory application of oral microbiology in early warning of disease risk, early diagnosis, treatment and evaluation of curative effect, etc. This paper discusses the potential of oral microbiology in the development of precision medicine and the great challenge of integrating oral microorganism information to achieve precision medicine.
【作者單位】： 口腔疾病研究國家重點實驗室國家口腔疾病臨床醫(yī)學(xué)研究中心四川大學(xué)華西口腔醫(yī)院牙體牙髓病科;
【基金】：國家自然科學(xué)基金(81670978,81600874) 四川省科技廳重大前沿項目(2016JY0006) 四川大學(xué)華西口腔醫(yī)院臨床新技術(shù)項目(LCXJS2015-3)~~
【分類號】：R780.2

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