本文選題：化膿性頜骨骨髓炎 + 放射性頜骨骨髓炎　； 參考：《口腔醫(yī)學(xué)研究》2017年10期

【摘要】：目的:對(duì)化膿性及放射性下頜骨骨髓炎患者病變骨組織進(jìn)行免疫組化染色,檢測(cè)IL-17、IL-6和IL-1β在2種不同病因的頜骨骨髓炎中的表達(dá)情況。方法:取化膿性及放射性頜骨骨髓炎患者病變骨組織做樣本,HE染色觀察局部骨組織的結(jié)構(gòu),并用免疫組織化學(xué)方法檢測(cè)局部組織中IL-17、IL-6和IL-1β的表達(dá)情況,與健康骨組織作對(duì)比。結(jié)果:IL-17、IL-6在化膿性頜骨骨髓炎中表達(dá)水平明顯升高,而放射性頜骨骨髓炎局部組織中IL-17、IL-6的表達(dá)與正常組織無顯著差異�；撔耘c放射性頜骨骨髓炎局部骨組織中IL-1β的表達(dá)水平與正常骨組織相比有顯著差異,而在2種骨髓炎中的表達(dá)差異不明顯。結(jié)論:IL-17、IL-6在化膿性頜骨骨髓炎的成骨與破骨失衡中可能有更重要的作用,而與放射性頜骨骨髓炎關(guān)系不密切。IL-1β是頜骨骨髓炎發(fā)生的重要因素。
[Abstract]:Objective: to detect the expression of IL-17, IL-6 and IL-1 尾 in osteomyelitis of mandible with purulent and radioactive osteomyelitis. Methods: the bone tissues of patients with suppurative and radiation-induced osteomyelitis were collected to observe the structure of local bone tissue by HE staining, and the expression of IL-6 and IL-1 尾 in local tissues were detected by immunohistochemical method, and the results were compared with those in healthy bone tissues. Results the expression of IL-6 in suppurative osteomyelitis of jaws was significantly increased, but there was no significant difference between the expression of IL-17 and IL-6 in the local tissues of radiation-induced osteomyelitis. The expression of IL-1 尾 in local bone tissue of suppurative osteomyelitis and radiation-induced osteomyelitis was significantly different from that in normal bone tissue, but there was no significant difference in the expression of IL-1 尾 between the two kinds of osteomyelitis. ConclusionIL-6 may play a more important role in osteogenesis and osteoclast imbalance in suppurative osteomyelitis of jaws, but it is not closely related to osteomyelitis of radioactivity. IL-1 尾 is an important factor in the development of osteomyelitis of jaw.
【作者單位】： 武漢大學(xué)口腔醫(yī)學(xué)院口腔生物醫(yī)學(xué)教育部重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(編號(hào):81371126)
【分類號(hào)】：R782.32

【相似文獻(xiàn)】

相關(guān)期刊論文 前2條

1 彭于治;蔡揚(yáng);;復(fù)發(fā)性阿弗他潰瘍患者血清中IL-17和IL-23的表達(dá)[J];貴陽醫(yī)學(xué)院學(xué)報(bào);2014年01期

2 謝三祥;梁順宇;朱聲榮;丁蕾;;IL-17在OLP病損中的表達(dá)及其作用機(jī)制的研究[J];臨床口腔醫(yī)學(xué)雜志;2014年05期

相關(guān)碩士學(xué)位論文 前1條

1 常煒;種植體周齦溝液中IL-17、IL-23濃度的測(cè)定及其意義[D];山西醫(yī)科大學(xué);2012年

，

本文編號(hào)：2108110