本文選題：頜面部感染 + 病原菌��； 參考：《中國感染控制雜志》2017年11期

【摘要】：目的了解頜面部感染患者病原菌分布及其藥物敏感性,為臨床合理使用抗菌藥物提供依據(jù)。方法收集2012年1月—2016年12月某醫(yī)院口腔頜面部感染患者標本進行病原菌培養(yǎng),對病原菌進行鑒定和藥敏檢測,分析病原菌分布及耐藥性。結果882例頜面部感染患者中男性占32.20%,女性占67.80%;年齡為~40歲、~60歲組的患者較多,分別占35.38%和32.65%;共分離病原菌145株,革蘭陰性菌88株,占60.69%,以肺炎克雷伯菌和銅綠假單胞菌為主;革蘭陽性菌56株,占38.62%,以金黃色葡萄球菌為主。肺炎克雷伯菌對檢測的16種藥物的耐藥率均50%,對亞胺培南和美羅培南的耐藥率最低,均為3.45%,11株為產(chǎn)超廣譜β-內(nèi)酰胺酶(ESBLs)陽性菌株;銅綠假單胞菌對檢測的10種藥物耐藥率均40%。金黃色葡萄球菌對替加環(huán)素、利奈唑胺、萬古霉素均敏感,對青霉素的耐藥率最高(66.67%),對苯唑西林的耐藥率為20.83%。結論口腔頜面部感染病原菌以革蘭陰性菌為主,不同病原菌耐藥性差別較大,在臨床治療時,應根據(jù)藥敏結果合理使用抗菌藥物。
[Abstract]:Objective to investigate the distribution of pathogens and drug sensitivity in patients with maxillofacial infection and to provide evidence for rational use of antimicrobial agents. Methods from January 2012 to December 2016, samples from patients with oral and maxillofacial infection in a hospital were collected for pathogen culture, pathogen identification and drug sensitivity detection, and distribution and drug resistance of pathogens were analyzed. Results among the 882 patients with maxillofacial infection, 32.20 were male, 67.80 were female, and 35.38% and 32.65% were in the age group of 40 years old and 60 years old, 145 strains were isolated, 88 strains were Gram-negative bacteria, and 60.69% were Klebsiella pneumoniae and Pseudomonas aeruginosa, respectively, and the main ones were Klebsiella pneumoniae and Pseudomonas aeruginosa. Gram-positive bacteria 56 strains (38.62%), mainly Staphylococcus aureus. The resistance rates of Klebsiella pneumoniae to 16 drugs tested were 50 and those to imipenem and meropenem were the lowest, which were 3.455.11 strains producing extended-spectrum 尾 -lactamases (ESBLs), and the resistance rates of Pseudomonas aeruginosa to 10 kinds of drugs were 40.5%. Staphylococcus aureus was sensitive to tegacycline, linazolamine and vancomycin. The resistance rate of Staphylococcus aureus to penicillin was the highest (66.67%), and the resistance rate to oxacillin was 20.83%. Conclusion Gram-negative bacteria are the main pathogens of oral and maxillofacial infection, and the drug resistance of different pathogens varies greatly. In clinical treatment, antibiotics should be used reasonably according to the results of drug sensitivity.
【作者單位】： 云南省第二人民醫(yī)院/云南大學第一醫(yī)院;
【基金】：云南省教育廳科學研究基金項目(2013Y285)
【分類號】：R782.3
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本文編號：2073867