發(fā)布時間：2018-06-04 00:00

  本文選題：頜下腺腫瘤 + 滑膜肉瘤��； 參考：《臨床與實驗病理學(xué)雜志》2015年04期

【摘要】：目的探討滑膜肉瘤(synovial sarcoma,SS)的臨床病理學(xué)特征、影像學(xué)表現(xiàn)、診斷及鑒別診斷。方法對1例4歲兒童頜下腺SS進行回顧性分析,并復(fù)習(xí)相關(guān)文獻。結(jié)果患兒B超示左頜下混合性包塊,MIR示類圓形團塊狀軟組織影,呈均勻等信號,局部牙槽骨可見骨質(zhì)破壞。鏡檢:腫瘤細(xì)胞梭形,呈束狀、漩渦狀排列且相互交叉。細(xì)胞豐富密集,異型性不明顯,核呈短梭形,核分裂象少見。間質(zhì)血管呈裂隙狀,管壁薄。免疫表型:部分腫瘤細(xì)胞CK(AE1/AE3)和CD99呈陽性,大部分腫瘤細(xì)胞EMA和vimentin呈陽性,BCL-2彌漫陽性,CD34、CD68、Pan-mel、SMA等均陰性。結(jié)論發(fā)生于頜下腺的SS易誤診,結(jié)合影像學(xué)表現(xiàn)、組織學(xué)形態(tài)及免疫表型可確診。
[Abstract]:Objective to investigate the clinicopathological features, imaging features, diagnosis and differential diagnosis of synovial sarcoma (SSS). Methods A 4-year-old child with SS in the submandibular gland was retrospectively analyzed and the related literature was reviewed. Results B-mode ultrasound showed mixed mass of left submaxillary mass (Mir) showed round mass of soft tissue with homogeneous signal intensity and bone destruction in local alveolar bone. Microscopic examination: tumor cells are fusiform, bunchy, swirling and intersecting. The cells are abundant and dense, the heterogeneity is not obvious, the nucleus is short fusiform, and the mitosis is rare. The interstitial vessels were fissured and the wall was thin. Immunophenotype: some tumor cells were positive for CKE 1 / AE3) and CD99, and most of tumor cells were positive for EMA and vimentin. Conclusion SS in submandibular gland is easy to be misdiagnosed, and combined with imaging findings, histological morphology and immunophenotype can be diagnosed.
【作者單位】： 第四軍醫(yī)大學(xué)西京醫(yī)院病理科;
【分類號】：R739.8

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本文編號：1974829