本文選題：涎腺腫瘤 + 腺樣囊性癌　； 參考：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2017年04期

【摘要】：目的初步探討HPV感染及p53、p16、EGFR及Cdc2表達(dá)與涎腺腺樣囊性癌(adenoid cystic carcinoma,ACC)預(yù)后的關(guān)系。方法收集76例涎腺ACC手術(shù)標(biāo)本,分別采用PCR-DNA反向點(diǎn)雜交及免疫組化SP法檢測(cè)腫瘤組織中HPV-DNA及p53、p16、EGFR及Cdc2表達(dá),收集臨床資料并隨訪。Kaplan-Meier模型分析患者生存情況,Log-rank檢驗(yàn)比較生存曲線,多因素Cox回歸模型進(jìn)行預(yù)后分析。結(jié)果涎腺ACC組織中HPV感染率為0(0/76)。p53、p16、EGFR及Cdc2蛋白在腫瘤組織中的陽性率分別為76.3%(58/76)、57.9%(44/76)、60.5%(46/76)及64.5%(49/76)。p53、p16、EGFR及Cdc2蛋白表達(dá)與患者性別、年齡、腫瘤部位、TNM分期及病理類型無關(guān)(P均0.05)。EGFR陽性患者中位總生存期(overall survival,OS)低于陰性患者(χ~2=19.111,P0.01)。EGFR陽性患者中位無進(jìn)展生存期(progression-free survival,PFS)低于陰性患者(χ~2=6.621,P0.01)。Cdc2陽性患者中位OS短于陰性患者(χ~2=3.870,P0.05)。Cdc2陽性患者中位PFS低于陰性患者(χ~2=6.755,P0.01)。多因素Cox回歸模型分析顯示EGFR、Cdc2蛋白表達(dá)(RR=13.417、13.075,P均0.001)是涎腺ACC患者預(yù)后的獨(dú)立危險(xiǎn)因素。結(jié)論涎腺ACC組織中未檢測(cè)出HPV感染。p53、p16、EGFR及Cdc2蛋白在涎腺ACC組織中呈不同程度表達(dá),p16不能作為涎腺ACC患者HPV感染狀態(tài)的替代指標(biāo)。EGFR及Cdc2陽性表達(dá)是涎腺ACC患者預(yù)后的獨(dú)立危險(xiǎn)因素,臨床對(duì)EGFR及Cdc2蛋白表達(dá)患者應(yīng)密切隨訪。
[Abstract]:Objective to investigate the relationship between HPV infection, expression of p53 p16 EGFR and Cdc2 and prognosis of adenoid cystic carcinoma of salivary gland.Methods 76 cases of salivary gland ACC were collected and the expression of HPV-DNA, p53 p16EGFR and Cdc2 in tumor tissues were detected by PCR-DNA reverse dot hybridization and immunohistochemical SP method. The clinical data were collected and the survival curves were analyzed by Kaplan-Meier model.Multivariate Cox regression model was used to analyze the prognosis.The median PFS of the patients with positive CDc2 was lower than that of the patients with negative results (蠂 2: 3.870, P 0.05, P 0.01).Multivariate Cox regression analysis showed that the expression of EGFR r-Cdc2 protein was an independent risk factor for the prognosis of salivary gland ACC patients (P 0.001).Conclusion the expression of HPV infection, p53, p16, EGFR and Cdc2 protein in salivary gland ACC tissues is not detected in salivary gland ACC tissue. The expression of p16 protein in salivary gland ACC tissue can not be used as an alternative marker of HPV infection in salivary gland ACC patients. EGFR and Cdc2 positive expression are independent risk factors for prognosis of ACC patients with salivary gland ACC.Patients with EGFR and Cdc2 protein expression should be closely followed up.
【作者單位】： 河北省唐山市協(xié)和醫(yī)院病理科;唐山職業(yè)技術(shù)學(xué)院基礎(chǔ)醫(yī)學(xué)部病理學(xué)教研室;河北省唐山市人民醫(yī)院放化療科;
【分類號(hào)】：R739.8

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