本文選題：生物相容性材料　切入點：口腔　出處：《中國組織工程研究》2017年10期

【摘要】：背景:光固化復合樹脂由于色澤美觀、優(yōu)良的物理、化學性能及操作簡單等在牙科缺損修復中得到應用。但是,復合樹脂由于力學性能不足容易引起復合體折斷,導致臨床使用難以達到預期治療效果。目的:探討填料協(xié)同增強增韌光固化樹脂基口腔材料的制備方法、性能及生物力學特征。方法:以原子轉移自由基聚合方法對納米二氧化硅進行表面接枝聚甲基丙烯酸甲酯(SiO_2-PMMA)改性,獲得接枝SiO_2-PMMA,利用同軸靜電紡絲方法制備聚丙烯腈/聚甲基丙烯酸甲酯核-殼納米纖維,以銅網(wǎng)作為接收裝置獲得具備網(wǎng)格結構的二維乳酸-羥基乙酸共聚物納米纖維膜。以硅烷偶聯(lián)劑為原乙酯前驅(qū)體溶膠-沉淀法制備多尺度、多維度填料,采用硅烷偶聯(lián)劑進行改性。將接枝SiO_2-PMMA核-殼納米纖維、梯形聚硅氧烷材料與光固化樹脂基體進行復合,比較兩種復合樹脂材料的力學性能、體積收縮率、毒性、降解性能等。結果與結論:(1)復合樹脂斷裂形貌的電鏡表征:填料接枝SiO_2-PMMA核-殼納米纖維在光固化樹脂基體中能較好的分散,團聚現(xiàn)象相對較少,存在單分散現(xiàn)象;而梯形聚硅氧烷材料在光固化樹脂基體中分散不均勻,且在復合樹脂中甚至出現(xiàn)團聚現(xiàn)象;(2)彎曲強度、彎曲模量及斷裂功:填料接枝SiO_2-PMMA核-殼納米纖維光固化樹脂基口腔材料的彎曲強度、彎曲模量及斷裂功顯著高于梯形聚硅氧烷材料光固化樹脂基口腔材料(P0.05);(3)體積收縮率:填料接枝Si O2-PMMA核-殼納米纖維光固化樹脂基口腔材料的體積收縮率低于梯形聚硅氧烷材料光固化樹脂基口腔材料(P0.05);(4)性能測定:填料接枝Si O2-PMMA核-殼納米纖維光固化樹脂基口腔材料吸水性及細胞毒性A值高于梯形聚硅氧烷材料光固化樹脂基口腔材料(P0.05),而溶解值低于梯形聚硅氧烷材料光固化樹脂基口腔材料(P0.05);(5)提示制備的填料協(xié)同增強增韌光固化樹脂基口腔材料具備優(yōu)良的性能和生物力學特征。
[Abstract]:Background: light-cured composite resin has been applied in dental defect repair because of its beautiful color, excellent physical and chemical properties and simple operation.However, due to the lack of mechanical properties of composite resin, it is easy to cause the complex to break, which makes it difficult to achieve the expected therapeutic effect in clinical use.Objective: to study the preparation, properties and biomechanical characteristics of the stuffing synergistic reinforcing light curing resin based oral materials.Methods: surface grafted poly (methyl methacrylate) sio _ 2-PMMA was modified by atom transfer radical polymerization.SiO2-PMMA was grafted onto SiO2-PMMA.The coaxial electrospinning method was used to prepare polyacrylonitrile / poly (methyl methacrylate) core-shell nanofibers. A two-dimensional lactic acid-glycolic acid copolymer nanofiber film with grid structure was obtained by using copper mesh as the receiving device.Using silane coupling agent as precursor of ethyl ester sol-precipitation method, multi-dimensional and multi-dimensional fillers were prepared and modified by silane coupling agent.The grafted SiO_2-PMMA core-shell nanofibers, trapezoidal polysiloxane materials and light-cured resin matrix were combined to compare the mechanical properties, volume shrinkage, toxicity and degradation properties of the two composite resins.Results and conclusion the fracture morphology of the composite resin was characterized by electron microscope: the filler grafted SiO_2-PMMA core-shell nanofibers could be dispersed in the resin matrix, and the agglomeration phenomenon was relatively small, and the phenomenon of monodispersity existed.However, the trapezoidal polysiloxane material was dispersed inhomogeneously in the light curing resin matrix, and even agglomerated in the composite resin.Flexural modulus and fracture work: flexural strength of SiO_2-PMMA core shell nano-fiber photocurable resin based oral materials grafted with filler,The flexural modulus and fracture work were significantly higher than those of trapezoidal polysiloxane photocurable resin based oral materials (P 0.05 / 3). The volume shrinkage rate of filler grafted Si O2-PMMA core shell nano-fiber photocurable resin based oral materials was lower than that of trapezoidal polysiloxane materials.Determination of the Properties of Polysiloxane Resin based Stomaterials (P0.05): the absorbency and Cytotoxicity A value of packed Si O2-PMMA Nano-fiber Photocurable Resin-based Oral Materials is higher than that of trapezoid Polysiloxane Photocurable ResinsThe results showed that the fillers had excellent properties and biomechanical properties, while the dissolution value was lower than that of trapezoid polysiloxane materials.
【作者單位】： 宜賓市第一人民醫(yī)院口腔科;西南醫(yī)科大學;
【基金】：四川省衛(wèi)生科技創(chuàng)新項目(2014K0122)~~
【分類號】：R783.1

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本文編號：1729255