本文選題：牙周基礎(chǔ)治療　切入點：牙周炎　出處：《中華高血壓雜志》2017年08期

【摘要】：目的研究牙周基礎(chǔ)治療對牙周炎伴冠狀動脈性心臟病(冠心病)患者血清、齦溝液中單核細(xì)胞趨化蛋白1(MCP-1)含量的影響。方法根據(jù)冠心病和牙周炎的診斷標(biāo)準(zhǔn)及納入標(biāo)準(zhǔn),采用隨機平行分組的方法入選福建醫(yī)科大學(xué)附屬第一醫(yī)院口腔科的牙周炎伴冠心病患者46例,其中治療組23例,進(jìn)行牙周基礎(chǔ)治療,包括口腔衛(wèi)生宣教、全口齦上潔治、齦下刮治、根面平整術(shù)、調(diào)牙合、拔除無法保留的牙;對照組23例,僅進(jìn)行口腔衛(wèi)生宣教,而不進(jìn)行系統(tǒng)牙周基礎(chǔ)治療。于治療前、治療后3、6個月,檢測血清和齦溝液中MCP-1含量,并記錄出血指數(shù)、牙周袋探診深度(PD)、附著喪失等指標(biāo)。結(jié)果對照組治療3、6個月后血清和齦溝液MCP-1水平與治療前比較,差異無統(tǒng)計學(xué)意義(P0.05)。治療組中,與治療前比較,治療3、6個月的血清MCP-1水平差異無統(tǒng)計學(xué)意義(P0.05),而齦溝液MCP-1水平明顯減低[(15.80±3.27)、(17.10±8.08)比(28.62±18.65)μg/L,均P0.05]。與對照組比較,治療組治療3、6個月時的出血指數(shù)、PD和附著喪失明顯降低(均P0.05)。結(jié)論牙周基礎(chǔ)治療可以降低牙周炎伴冠心病患者齦溝液內(nèi)的MCP-1水平,對血清MCP-1水平影響較小。
[Abstract]:Objective to study the effect of periodontal basic therapy on monocyte chemoattractant protein 1 (MCP-1) in serum and gingival crevicular fluid (GCF) of patients with periodontitis and coronary heart disease (CHD).Methods according to the diagnostic criteria and inclusion criteria of coronary heart disease and periodontitis, 46 patients with periodontitis associated with coronary heart disease in the Department of Stomatology of the first affiliated Hospital of Fujian Medical University were randomly divided into treatment group (23 cases) and treatment group (23 cases).Basic periodontal treatment, including oral hygiene education, whole oral upper gingival scaling, subgingival curettage, root surface leveling, adjustment of occlusion, extraction of teeth that could not be retained, and control group (23 cases) were treated with oral hygiene education only.No systematic periodontal treatment was performed.The levels of MCP-1 in serum and gingival crevicular fluid were measured before treatment, 3 months and 6 months after treatment, and the indexes of bleeding index, depth of periodontal bag probing and attachment loss were recorded.Results the levels of MCP-1 in serum and gingival crevicular fluid in the control group were not significantly different from those before treatment 3 and 6 months after treatment (P 0.05).In the treatment group, there was no significant difference in serum MCP-1 level between 3 and 6 months after treatment, but the MCP-1 level in gingival crevicular fluid was significantly decreased [15.80 鹵3.27, 17.10 鹵8.08] compared with 28.62 鹵18.65 渭 g / L, P0.05].Compared with the control group, the bleeding index (PD) and attachment loss in the treatment group were significantly lower than those in the control group at 3 and 6 months (all P 0.05).Conclusion periodontal basic therapy can reduce the level of MCP-1 in gingival crevicular fluid of patients with periodontitis and coronary heart disease, and has little effect on serum MCP-1 level.
【作者單位】： 福建醫(yī)科大學(xué)附屬第一醫(yī)院口腔科;
【基金】：中華口腔醫(yī)學(xué)會口腔疾病與全身疾病關(guān)系研究項目(CSAY2015-09) 福建省自然科學(xué)基金資助項目(2017J05124)
【分類號】：R541.4;R781.42

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