發(fā)布時間：2018-03-18 21:33

  本文選題：慢性唇炎　切入點：主動維持療法　出處：《口腔醫(yī)學(xué)研究》2017年07期 　論文類型：期刊論文

【摘要】：目的:采用主動維持療法,觀察0.03%他克莫司軟膏治療兒童和青少年慢性唇炎的療效,并對其安全性進行評價。方法:本試驗共分為2個階段:治療階段(第一階段)與主動維持階段(第二階段)。在試驗第一階段,將40例慢性唇炎患者隨機分為2組,試驗組25例,對照組15例。試驗組首先濕敷復(fù)方氯己定溶液,再涂用0.03%他克莫司軟膏。對照組僅濕敷復(fù)方氯己定,每天2次,連續(xù)2周。試驗組中痊愈和顯效的患者進入第二階段,并隨機分配至試驗組或?qū)φ战M,試驗組采用間歇性主動維持療法,對照組在本階段不進行間歇維持治療,如病損復(fù)發(fā)時采用常規(guī)治療,兩組的觀察期均為6個月。結(jié)果:第一階段,他克莫司組痊愈21例,顯效3例,總有效率為96%,明顯高于對照組(60%),差異有統(tǒng)計學(xué)意義(P0.05)第一階段試驗結(jié)束后,試驗組24例患者進入第二階段,并隨機分為試驗組和對照組各12例。第二階段試驗組有效率為100%,對照組的有效率為91.7%,差異無統(tǒng)計學(xué)意義。試驗組首次出現(xiàn)復(fù)發(fā)的時間均值為(95.5±9.2)d,對照組均值為(26.6±10.0)d,差異具有統(tǒng)計學(xué)意義。試驗組患者復(fù)發(fā)率16.7%明顯低于對照組患者58.3%,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:0.03%他克莫司軟膏采用主動維持療法能顯著降低兒童和青少年慢性唇炎的復(fù)發(fā),療效好且安全。
[Abstract]:Objective: to observe the efficacy of 0.03% tacrolimus ointment in the treatment of chronic lipitis in children and adolescents by active maintenance therapy. Methods: this study was divided into two stages: treatment stage (the first stage) and active maintenance stage (the second stage). In the first stage of the trial, 40 patients with chronic lipitis were randomly divided into two groups. There were 25 cases in the test group and 15 cases in the control group. The test group was first wet with compound chlorhexidine solution and then with 0.03% tacrolimus ointment, while the control group was only wet with compound chlorhexidine twice a day. The patients in the trial group who were cured and effective entered the second stage and were randomly assigned to the experimental group or the control group. The experimental group received intermittent active maintenance therapy, while the control group did not undergo intermittent maintenance therapy at this stage. The observation period was 6 months in both groups. Results: in the first stage, 21 cases were cured in tacrolimus group, 3 cases were effective. The total effective rate was 96%, which was significantly higher than that of the control group (60%). The difference was statistically significant (P 0.05). After the first phase of the trial, 24 patients in the trial group entered the second stage. The effective rate of the second stage trial group was 100, the control group was 91.70.The mean time of the first recurrence in the trial group was 95.5 鹵9.2 days, and the average value of the control group was 26.6 鹵10.0 days. The recurrence rate of 16.7% patients in the trial group was significantly lower than that in the control group (58.3%), and the difference was statistically significant (P 0.05). Conclusion the active maintenance therapy with 0. 03% tacrolimus ointment can significantly reduce the recurrence of chronic lipitis in children and adolescents. The effect is good and safe.
【作者單位】： 南方醫(yī)科大學(xué)口腔醫(yī)院黏膜牙周科;
【基金】：國家自然科學(xué)基金(編號:81500850)
【分類號】：R781.56

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本文編號：1631397