本文選題：口腔鱗狀細(xì)胞癌　切入點(diǎn)：基質(zhì)金屬蛋白酶-　出處：《空軍醫(yī)學(xué)雜志》2016年02期 　論文類(lèi)型：期刊論文

【摘要】：目的探討基質(zhì)金屬蛋白酶-14(matrix metalloproteinase 14,MMP-14)和細(xì)胞外基質(zhì)金屬蛋白酶誘導(dǎo)因子(extracellular matrix metalloproteinase inducer,EMMPRIN)在口腔鱗狀細(xì)胞癌(oral squamous cell carcinoma,OSCC)中的臨床意義,并分析二者的相關(guān)性。方法選取2012年1月—2014年6月于我院口腔頜面外科診治的69例OSCC患者作為OSCC組,同時(shí)選取43例口腔正常新鮮組織標(biāo)本作為對(duì)照組。采用逆轉(zhuǎn)錄-聚合酶鏈反應(yīng)技術(shù)檢測(cè)組織中的MMP-14及EMMPRIN m RNA的表達(dá)含量。結(jié)果 MMP-14 m RNA、EMMPRIN m RNA在OSCC組中的相對(duì)表達(dá)量明顯高于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(t=8.198、9.624,P0.01);OSCC組患者在年齡、性別因素中的MMP-14、EMMPRIN m RNA的表達(dá)差異不明顯(P0.05),在伴有淋巴結(jié)轉(zhuǎn)移的患者中均明顯升高(t=2.909、2.156,P0.05);且MMP-14、EMMPRIN m RNA在Ⅲ~Ⅳ期、中低分化的OSCC中表達(dá)均明顯升高,差異具有統(tǒng)計(jì)學(xué)意義(t=3.376、2.667、3.027、2.399,P0.05);MMP-14與EMMPRIN m RNA表達(dá)含量間相關(guān)系數(shù)為r=0.821,二者呈正相關(guān)性(P0.01)。結(jié)論 OSCC組織中MMP-14和EMMPRIN m RNA的高表達(dá)狀態(tài)均與腫瘤的病理分期、分化程度及淋巴結(jié)轉(zhuǎn)移因素關(guān)系密切,二者的表達(dá)具有正相關(guān)性,提示MMP-14和EMMPRIN均參與了OSCC的浸潤(rùn)及轉(zhuǎn)移過(guò)程,通過(guò)檢測(cè)EMMPRIN及MMP-14 m RNA表達(dá)含量可能有助于OSCC的病變程度及預(yù)后轉(zhuǎn)歸判斷。
[Abstract]:Objective to investigate the clinical significance of matrix metalloproteinase-14 matrix metalloproteinase 14 (MMP-14) and extracellular matrix metalloproteinase inducer (EMMPRIN) in oral squamous cell carcinoma of oral squamous cell carcinoma (OSCC). Methods from January 2012 to June 2014, 69 patients with OSCC treated in oral and maxillofacial surgery in our hospital were selected as OSCC group. The expression of MMP-14 and EMMPRIN m RNA were detected by reverse transcription-polymerase chain reaction (RT-PCR). Results the relative expression of MMP-14 m RNAEMMPRIN m RNA in OSCC group was detected by reverse transcription-polymerase chain reaction (RT-PCR). The quantity was significantly higher than that in control group. There was no significant difference in the expression of MMP-14 EMMPRIN m RNA in age and sex factors in patients with OSCC. The expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m RNA in patients with lymph node metastasis was significantly higher than that in patients with lymph node metastasis, and the expression of MMP-14 EMMPRIN m in stage 鈪，

本文編號(hào)：1611319