本文關(guān)鍵詞：低收縮牙科樹(shù)脂體系及抗菌納米粒子改性研究　出處：《南京理工大學(xué)》2016年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 牙科修復(fù)樹(shù)脂 超支化單體 膨脹單體 抗菌納米粒子 光固化

【摘要】：傳統(tǒng)的牙科修復(fù)樹(shù)脂在光固化過(guò)程中產(chǎn)生體積收縮造成牙體與修復(fù)體間的縫隙(微滲漏),修復(fù)樹(shù)脂的微滲漏與不具有抗菌性能是繼發(fā)齲的主要原因。超支化聚合物因?yàn)槠涓叨戎Щ娜S結(jié)構(gòu),用于減少牙科修復(fù)樹(shù)脂聚合收縮具有很大的潛力。膨脹單體也因?yàn)槠溟_(kāi)環(huán)聚合具有體積膨脹效應(yīng),也被用于牙科修復(fù)樹(shù)脂中�？梢宰鳛樘盍嫌玫募{米金剛石(ND)其表面含有大量的活性基團(tuán),對(duì)其進(jìn)行表面修飾后的產(chǎn)物加入到修復(fù)樹(shù)脂中可以同時(shí)增加其機(jī)械性能和抗菌性能。本文通過(guò)“準(zhǔn)一步法”合成末端含有7個(gè)雙鍵,6個(gè)丙基,3個(gè)羥基的Boltorn型可聚合超支化聚酯(GHBP3)和膨脹單體3,9-二乙基-3,9-丙烯氧甲基-1,5,7,11-四氧螺雜[5,5]十一烷(BAOM)。利用FT-IR、1H-NMR及13C-NMR對(duì)HBP、GHBP3、BAOM進(jìn)行表征,并測(cè)得HBP支化度。將上述BAOM與3,4-環(huán)氧環(huán)己基甲基-3,4-環(huán)氧環(huán)己基甲酸酯按質(zhì)量比1：1混合(BAOM-EE),加之GHBP3、Bis-GMA以不同比例混合后固化,測(cè)定其雙鍵轉(zhuǎn)化率,收縮率,吸水率,親水性,綜合評(píng)價(jià)其性能。親水性和吸水率均滿(mǎn)足基本要求,根據(jù)雙鍵轉(zhuǎn)化率和收縮率的情況,最終選擇比例為30%BAOM-EE, 25%GHBP3,45%Bis-GMA的樹(shù)脂體系。以納米金剛石(ND)、3-溴丙基三甲氧基硅烷、聚乙烯基吡啶、溴代正己烷和KPF6為原料合成季銨鹽修飾的改性納米金剛石ND-Q6PF6。利用FT-IR和1H-NMR對(duì)其進(jìn)行表征。并考察其對(duì)大腸桿菌和金黃色葡萄球菌的抗菌效果(最小抑菌濃度MIC值和最小殺菌濃度MBC值),其對(duì)大腸桿菌的MIC和MBC值分別為62.5μg/mL、125μg/mL,具有很好殺菌效果。將ND-Q6PF6以不同比例加入到最佳比例的樹(shù)脂中進(jìn)行固化,并測(cè)定其收縮率,雙鍵轉(zhuǎn)化率,親水性,抗菌性能以及其在樹(shù)脂片中的分散情況,實(shí)驗(yàn)結(jié)果得出ND-Q6PF6的質(zhì)量含量在1%以下時(shí)分散性較好,同時(shí)具有良好的抗菌性能。
[Abstract]:The volume contraction of traditional dental restorative resin in the process of light curing results in the gap (microleakage) between the tooth and the prosthesis. The microleakage and non-antibacterial properties of the repair resin were the main causes of secondary caries. The hyperbranched polymer was due to its highly branched three-dimensional structure. It has great potential to reduce the shrinkage of dental repair resin polymerization. Expansion monomer also has volume expansion effect because of its ring-opening polymerization. It is also used in dental restorative resins. Nanocrystalline diamond (NDN), which can be used as filler, contains a large number of active groups on its surface. The addition of the surface modified product to the repair resin can increase both its mechanical and antibacterial properties. In this paper, seven double bonds and six propyl groups were synthesized by "quasi one step" method. Three hydroxyl Boltorn Polymeric Hyperbranched Polyester (GHBP3) and expansion Monomer 3O9- diethyl-3-Propylene Methyl Methyl -1Con 711- Tetraoxomethoxy Spiro. [5 ~ (5) undecane BAOMC.FT-IRN ~ (1H-NMR) and ~ (13) C-NMR were used to characterize HBP- GHBP3BOM. The HBP branching degree was measured. The above BAOM was mixed with 3N 4-epoxy-cyclohexyl methyl-3-epoxycyclohexyl 4-epoxy-cyclohexyl formate at mass ratio of 1: 1, BAOM-EEN, plus GHBP3. The Bis-GMA was cured with different proportion. The conversion of double bond, shrinkage, water absorption and hydrophilicity were measured. The properties of Bis-GMA were evaluated synthetically. The hydrophilicity and water absorption met the basic requirements. According to the double bond conversion and shrinkage, the resin system with the ratio of 30OM-EE and 25GHBP345Bis-GMA was selected. 3-bromopropyl trimethoxy silane, polyvinylpyridine. Modified nanocrystalline diamond ND-Q6PF6 modified by quaternary ammonium salt was synthesized from brominated n-hexane and KPF6. It was characterized by FT-IR and 1H-NMR. Escherichia coli and golden yellow were also investigated. Antibacterial effect of Staphylococcus chromostaphylococcus (. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The values of MIC and MBC for Escherichia coli were 62.5 渭 g / mL and 125 渭 g / mL, respectively. ND-Q6PF6 was added to the resin in different proportion to cure, and its shrinkage, double bond conversion and hydrophilicity were measured. The results showed that the dispersity of ND-Q6PF6 was better when the mass content of ND-Q6PF6 was below 1%, and it also had good antibacterial property.
【學(xué)位授予單位】：南京理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R783

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