本文關(guān)鍵詞：DNA甲基化在精神分裂癥中的作用:研究進展及挑戰(zhàn)（英文）

  更多相關(guān)文章： Schizophrenia Epigenetics DNA methylation Reelin Catechol-O-methyltransferase

【摘要】：精神分裂癥是一種異質(zhì)性精神障礙,目前多數(shù)學者認為該病由遺傳及環(huán)境風險因子共同致病.傳統(tǒng)的遺傳學研究識別了一些精神分裂癥的候選基因,然而,外顯率及比值比較低,以及可重復性較差,使得這些候選基因在精神分裂癥發(fā)病機制中的角色受到限制.精神分裂癥的流行病學研究發(fā)現(xiàn)了一些可能與該病相關(guān)的環(huán)境風險因子,但仍受到方法學的限制以及互相矛盾的流行病學調(diào)查結(jié)果的困擾.目前,在環(huán)境與基因中間起調(diào)解作用的表觀遺傳學,可能在精神分裂癥的發(fā)病機制中起重要作用.DNA甲基化是最穩(wěn)定且研究最深入的一種表觀遺傳學修飾.本文簡要介紹DNA甲基化機制,主要評述精神分裂癥中基因組及特異位點如候選基因Reelin與COMT甲基化研究現(xiàn)狀,以及DNA甲基化在精神分裂癥中的研究困境.
【作者單位】： Institute
【關(guān)鍵詞】： Schizophrenia Epigenetics DNA methylation Reelin Catechol-O-methyltransferase
【基金】：supported by the National Natural Science Foundation of China(81271484 and 81471361 toX.C,30900486 and 81371480 to J.T) the National Key Basic Research and Development Program(2012CB517904 to X.C)
【分類號】：R749.3
【正文快照】： 1 IntroductionSchizophrenia(SZ)comprises positive and negativesymptoms,cognitive deficits,and affective symptoms.Itaffects approximately 1%of the global population[1].Although conventional genetic studies have identifiedsome candidate genes for SZ[2],low

【相似文獻】

中國期刊全文數(shù)據(jù)庫 前10條

1 白志勇,白曉川,武淑蘭;RELATIONSHIP BETWEEN THE PATTERN OF METHYLATION OF CALCITONIN GENE AND ACTIVITY OF METHYLTRANSFERASEIN 8 TUMOR CELL LINES[J];Chinese Journal of Cancer Research;2001年03期

2 王志偉 ,易靜 ,倉輝 ,鄒鴻志 ,郁寶銘 ,湯雪明;P16 METHYLATION OF THE COLORECTAL CANCER AND ASSOCIATION WITH DUKES STAGES[J];Chinese Journal of Cancer Research;2001年04期

3 ;The First Symposium on Frontiers of Biomedical Sciences Organized by Cell Research "Epigenetics in Development and Diseases"[J];Cell Research;2003年05期

4 ;A novel protein-DNA interaction involved with the CpG dinucleotide at -30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene[J];Cell Research;2004年04期

5 ;Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis[J];World Journal of Gastroenterology;2004年09期

6 ;Expression of Dnmt1,demethylase,MeCP2 and methylation of tumor-related genes in human gastric cancer[J];World Journal of Gastroenterology;2004年23期

7 ;Microarray-based method for detecting methylation changes of p16~(Ink4a) gene 5'-CpG islands in gastric carcinomas[J];World Journal of Gastroenterology;2004年24期

8 Hsin Pai LI,Yu Wei LEU;Epigenetic changes in virus-associated human cancers[J];Cell Research;2005年04期

9 ;The altered DNA methylation pattern and its implications in liver cancer[J];Cell Research;2005年04期

10 ;Biallelic Inactivation of hMLH1 by Hypermethylation and Loss of Heterozygosity in Non-Small Cell Lung Cancer[J];Chinese Journal of Clinical Oncology;2006年03期

中國重要會議論文全文數(shù)據(jù)庫 前10條

1 潘世揚;謝而付;高麗;張麗霞;陳丹;黃佩s，

本文編號：841184