【摘要】：研究背景：先前研究發(fā)現(xiàn)創(chuàng)傷后應(yīng)激障礙患者腦部有異常改變，但是國內(nèi)外幾乎沒有文章報(bào)道創(chuàng)傷后應(yīng)激障礙患者的腦部皮質(zhì)厚度的改變。本研究的目的在于測量比較創(chuàng)傷后應(yīng)激障礙患者，幸存者及正常對照組之間的皮質(zhì)厚度差異，從而發(fā)現(xiàn)創(chuàng)傷后應(yīng)激障礙患者腦部皮質(zhì)厚度變化與其癥狀，和內(nèi)部網(wǎng)絡(luò)之間的聯(lián)系。 方法：利用3T磁共振采集在煤礦透水事故救上的幸存者高分辨T1加權(quán)成像圖，其中包括15名創(chuàng)傷后應(yīng)激障礙患者，10名受刺激沒有發(fā)病的，以及25名正常對照組。利用表面處理法比較3組之間的皮質(zhì)厚度差別，并對有差異區(qū)做局部相關(guān)處理。 結(jié)果：PTSD患者與正常對照組相比，在雙側(cè)頂葉，額葉，海馬區(qū)，以及扣帶回和右側(cè)枕葉皮質(zhì)厚度均有減少，在距狀裂有代償性升高，且PTSD患者腦部改變區(qū)域較有刺激而未患PTSD幸存者更多，在感興趣區(qū)比較研究中發(fā)現(xiàn)，，在受創(chuàng)傷的幸存者，扣帶前回，后回，前額葉，海馬區(qū)均與臨床CAPS積分有統(tǒng)計(jì)學(xué)負(fù)相關(guān)，距狀裂有正相關(guān)。 結(jié)論：本研究發(fā)現(xiàn)早期階段的PTSD患者不但在額顳連接網(wǎng)絡(luò)皮質(zhì)厚度有所減少，而且在邊緣系統(tǒng)皮質(zhì)有更多的減少。這些結(jié)果為早期PTSD腦部皮質(zhì)的減少與應(yīng)激之間的關(guān)系提供有利的影像學(xué)依據(jù)，為PTSD的臨床診斷和治療提供影像學(xué)指導(dǎo)。
[Abstract]:Background: previous studies have found abnormal changes in the brain of patients with post-traumatic stress disorder, but there are few articles at home and abroad on the changes of cerebral cortical thickness in patients with post-traumatic stress disorder. The purpose of this study was to measure and compare the cortical thickness between patients with post-traumatic stress disorder (PTSD), survivors and normal controls, so as to find the relationship between the changes of cortical thickness and its symptoms and internal network in patients with PTSD. Methods: high resolution T1 weighted imaging of survivors in coal mine permeable accident was collected by 3T magnetic resonance imaging, including 15 patients with post-traumatic stress disorder, 10 patients without stimulation and 25 normal controls. The difference of cortical thickness between the three groups was compared by surface treatment, and the local correlation treatment was performed on the difference area. Results: compared with the normal control group, the thickness of bilateral parietal lobe, frontalis, hippocampus, cingulate gyrus and right occipital cortex decreased, and there was a compensated increase in talus fissure, and there were more PTSD survivors in PTSD patients than in normal controls. In the comparative study of the area of interest, it was found that in the injured survivors, anterior cingulate gyrus, posterior cingulate gyrus, prefrontal lobe, The hippocampal area was negatively correlated with clinical CAPS score and positively correlated with talus fissure. Conclusion: in the early stage of PTSD, not only the thickness of frontotemporal network cortex decreased, but also more in the limbic cortex. These results provide favorable imaging basis for the relationship between cerebral cortex reduction and stress in early PTSD, and provide imaging guidance for clinical diagnosis and treatment of PTSD.
【學(xué)位授予單位】：第四軍醫(yī)大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.5

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相關(guān)期刊論文 前1條

1 陳樹林,李凌江,盧原,高雪屏,張錦黎,李晏,李衛(wèi)暉;火災(zāi)災(zāi)民創(chuàng)傷后應(yīng)激障礙的發(fā)生及其影響因素[J];中國神經(jīng)精神疾病雜志;2005年03期

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