MRI乳頭體體積測(cè)量及其在認(rèn)知功能障礙性疾病的初步應(yīng)用
發(fā)布時(shí)間：2019-05-27 14:28
【摘要】：目的； 觀察和分析正常成人乳頭體(MB)體積的對(duì)稱(chēng)性、隨年齡演變趨勢(shì)和性別差異,初步說(shuō)明MB體積在正F常成年人群的分布情況。觀察和分析以輕度認(rèn)知功能障礙(MCI)和阿爾茨海默病(AD)為代表的認(rèn)知功能障礙性疾病的MB體積變化,初步探討認(rèn)知功能障礙性疾病所致的MB體積變化趨勢(shì)及其臨床應(yīng)用價(jià)值。 方法: 選擇正常成人50例和年齡匹配的正常對(duì)照、MCI、AD患者各25例。采用GE HD-X3.0T超導(dǎo)型磁共振掃描儀采集正常成人和正常對(duì)照MR圖像；下載ADNI的MCI、AD患者M(jìn)R圖像。使用ITK-SNAP Version2.0.0軟件在三維高分辨率T1WI解剖像測(cè)量MB體積,對(duì)每個(gè)MB重復(fù)測(cè)量?jī)杀?取平均值為測(cè)量體積,取同一研究對(duì)象雙側(cè)測(cè)量體積之和為測(cè)量總體積,并以全腦體積進(jìn)行標(biāo)準(zhǔn)化處理得到標(biāo)化體積和標(biāo)化總體積。采用SPSS19.0統(tǒng)計(jì)軟件包對(duì)MB標(biāo)化體積指標(biāo)進(jìn)行統(tǒng)計(jì)分析：正常成人側(cè)別、年齡段、性別分別進(jìn)行配對(duì)樣本,檢驗(yàn)、單因素方差分析和獨(dú)立樣本t檢驗(yàn);MCI、AD組患者側(cè)別、性別分別進(jìn)行配對(duì)樣本,檢驗(yàn)、獨(dú)立樣本t檢驗(yàn);正常對(duì)照、MCI、AD組間進(jìn)行單因素方差分析。 結(jié)果: 正常成人MB標(biāo)化體積和標(biāo)化總體積平均值為100.2±11.2mm3和200.4±20.1mm3,按照側(cè)別、年齡段和性別分析MB標(biāo)化體積指標(biāo)均無(wú)統(tǒng)計(jì)學(xué)差異。MCI、AD組內(nèi)側(cè)別研究顯示,MB標(biāo)化體積右側(cè)(MCI92.2±19.4mm3, AD79.1±14.5mm3)大于左側(cè)(MCI82.9±17.2mm3, AD71.2±15.6mm3),差異均存在統(tǒng)計(jì)學(xué)意義(tmC1=3.920,tAD=3.422,p0.05)。MCI、AD組內(nèi)性別比較顯示,兩性間MB標(biāo)化體積指標(biāo)無(wú)統(tǒng)計(jì)學(xué)差異。正常對(duì)照,MCI及AD組間MB標(biāo)化體積、標(biāo)化總體積單因素方差分析均存在統(tǒng)計(jì)學(xué)差異(F標(biāo)化體積=35.965,F標(biāo)化總體積=21.610,p0.05),并且正常對(duì)照(標(biāo)化體積101.3±11.0mm3、標(biāo)化總體積202.5±19.7mm3)MCI(標(biāo)化體積87.6±18.8mm3、標(biāo)化總體積175.2±34.7mm3)AD(標(biāo)化體積75.2±15.4mm3、標(biāo)化總體積1503±27.8mm3),差異均存在統(tǒng)計(jì)學(xué)意義(p0.05)；三組間右側(cè)、左側(cè)組MB標(biāo)化體積單因素方差分析同樣存在統(tǒng)計(jì)學(xué)差異(F右側(cè)標(biāo)化體積=14.782,F左側(cè)標(biāo)化體積=23.366,p0.05),并且正常對(duì)照(右側(cè)102.5±10.4mm3、左側(cè)100.0±11.7mm3)MCI(右側(cè)92.2±19.41mm3、左側(cè)82.9±17.2mm3)AD(右側(cè)79.1±14.5mm3、左側(cè)71.2±15.6mm3),差異均存在統(tǒng)計(jì)學(xué)意義(p0.05)。 結(jié)論： 1.正常成人MB的體積分布特點(diǎn)：雙側(cè)基本對(duì)稱(chēng)、無(wú)明顯性別差異,坡重要的是隨年齡增加萎縮不明顯。 2.認(rèn)知功能障礙性疾病,如MCI、AD可伴有MB體積萎縮;MB體積萎縮可于AD早期出現(xiàn),且與病變進(jìn)程相一致,可作為AD早期較為敏感的腦體積變化指標(biāo),但特異性差 3. MCI、AD患者左側(cè)MB體積萎縮較右側(cè)明顯,提示在認(rèn)知功能障礙性疾病中MB受損的非對(duì)稱(chēng)性
[Abstract]:the purpose of the invention; The symmetry of the volume of the normal adult papilla (MB) was observed and analyzed, and the distribution of the MB volume in the normal adult population was preliminarily explained with the trend of age and the sex difference. The changes of MB volume in cognitive dysfunction caused by mild cognitive impairment (MCI) and Alzheimer's disease (AD) were observed and analyzed, and the change of MB volume caused by cognitive dysfunction and its clinical application were discussed. Value. Methods: The normal control, MCI and AD of 50 normal adults and 50 normal adults were selected. The normal adult and normal control MR images were collected by the GE HD-X3.0T superconducting magnetic resonance scanner, and the MCI and AD of the ADNI were downloaded. The MR image of the person was measured. Using the ITK-SNAP Version2.0.0 software, the MB volume was measured on the three-dimensional high-resolution T1WI anatomical image, and the measurement was repeated twice for each MB. The average value was the measured volume, and the sum of the two-sided measurement volume of the same study object was taken as the measurement volume. the total volume is measured and the normalized treatment is performed with the total brain volume to obtain the labeled volume and The volume index of MB is analyzed by using the SPSS19.0 statistical software package: the paired samples, the test, the single-factor analysis of variance and the independent sample t test are performed for the normal adult side, age and sex, respectively; and the side and the sex of the patients in the MCI and AD groups are respectively matched. Sample, test, independent sample t-test; normal control, MCI, AD group variance of prime Analysis. Results: The average volume and standard volume of the normal adult MB were 100.2-11.2 mm3 and 200.4-20.1 mm3, and the MB-labeled volume was analyzed according to the lateral, age and gender There was no statistical difference in the index. The inside of the MCI and AD group showed that the right of the MB standard volume (MCI92.2, 19.4 mm3, AD79.1, 14.5 mm3) was greater than that of the left (MCI82.9, 17.2 mm3, AD71.2, 15.6 mm3), and there was a statistical difference (tmC1 = 3.920, tAD = 3.4 22, p0.05). There was no statistical difference in the product index. There was a statistical difference between the normal control, the MCI and the AD group, and the variance analysis of the total volume of the standardized total volume (F-labeled volume = 35.965, F-labeled total volume = 21.610, p0.05), and the normal control (labeled volume 101). The difference was statistically significant (p0, with a total volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of MCI (a labeled volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of AD (labeled volume of 75.2-15.4 mm3, and a labeled total volume of 1503-27.8 mm3). There was also a statistical difference between the three groups on the right side and on the left side group of MB standard volume single factor analysis of variance (F-side scale volume = 14.782, F left-side labeled volume = 23.366, p0.05), and the normal control (right 102.5-10.4 mm3, left 100.0-11.7 mm3) MCI (right 92.2-19.41 mm3, left-hand 82.9-17.2 mm3) AD (right 79). 1 to 14.5 mm3 (71.2 to 15.6 mm3 on the left), and there was a difference in the difference meaning ( p0.05). Conclusion:1. The volume distribution of normal adult MB: bilateral basic symmetry, no significant gender difference, slope weight It is not obvious to increase the atrophy with age.2. The cognitive dysfunction disease, such as MCI, AD, can be associated with the atrophy of MB, and the atrophy of MB can occur in the early stage of AD and in line with the pathological process, which can be used as the early AD of AD. sensitive brain volume The change index, but the specific difference 3. MCI, the left-hand MB volume of the AD patient is obviously lower than the right side, and the prompt is to be recognized.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R749.16
本文編號(hào)：2486223
[Abstract]:the purpose of the invention; The symmetry of the volume of the normal adult papilla (MB) was observed and analyzed, and the distribution of the MB volume in the normal adult population was preliminarily explained with the trend of age and the sex difference. The changes of MB volume in cognitive dysfunction caused by mild cognitive impairment (MCI) and Alzheimer's disease (AD) were observed and analyzed, and the change of MB volume caused by cognitive dysfunction and its clinical application were discussed. Value. Methods: The normal control, MCI and AD of 50 normal adults and 50 normal adults were selected. The normal adult and normal control MR images were collected by the GE HD-X3.0T superconducting magnetic resonance scanner, and the MCI and AD of the ADNI were downloaded. The MR image of the person was measured. Using the ITK-SNAP Version2.0.0 software, the MB volume was measured on the three-dimensional high-resolution T1WI anatomical image, and the measurement was repeated twice for each MB. The average value was the measured volume, and the sum of the two-sided measurement volume of the same study object was taken as the measurement volume. the total volume is measured and the normalized treatment is performed with the total brain volume to obtain the labeled volume and The volume index of MB is analyzed by using the SPSS19.0 statistical software package: the paired samples, the test, the single-factor analysis of variance and the independent sample t test are performed for the normal adult side, age and sex, respectively; and the side and the sex of the patients in the MCI and AD groups are respectively matched. Sample, test, independent sample t-test; normal control, MCI, AD group variance of prime Analysis. Results: The average volume and standard volume of the normal adult MB were 100.2-11.2 mm3 and 200.4-20.1 mm3, and the MB-labeled volume was analyzed according to the lateral, age and gender There was no statistical difference in the index. The inside of the MCI and AD group showed that the right of the MB standard volume (MCI92.2, 19.4 mm3, AD79.1, 14.5 mm3) was greater than that of the left (MCI82.9, 17.2 mm3, AD71.2, 15.6 mm3), and there was a statistical difference (tmC1 = 3.920, tAD = 3.4 22, p0.05). There was no statistical difference in the product index. There was a statistical difference between the normal control, the MCI and the AD group, and the variance analysis of the total volume of the standardized total volume (F-labeled volume = 35.965, F-labeled total volume = 21.610, p0.05), and the normal control (labeled volume 101). The difference was statistically significant (p0, with a total volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of MCI (a labeled volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of AD (labeled volume of 75.2-15.4 mm3, and a labeled total volume of 1503-27.8 mm3). There was also a statistical difference between the three groups on the right side and on the left side group of MB standard volume single factor analysis of variance (F-side scale volume = 14.782, F left-side labeled volume = 23.366, p0.05), and the normal control (right 102.5-10.4 mm3, left 100.0-11.7 mm3) MCI (right 92.2-19.41 mm3, left-hand 82.9-17.2 mm3) AD (right 79). 1 to 14.5 mm3 (71.2 to 15.6 mm3 on the left), and there was a difference in the difference meaning ( p0.05). Conclusion:1. The volume distribution of normal adult MB: bilateral basic symmetry, no significant gender difference, slope weight It is not obvious to increase the atrophy with age.2. The cognitive dysfunction disease, such as MCI, AD, can be associated with the atrophy of MB, and the atrophy of MB can occur in the early stage of AD and in line with the pathological process, which can be used as the early AD of AD. sensitive brain volume The change index, but the specific difference 3. MCI, the left-hand MB volume of the AD patient is obviously lower than the right side, and the prompt is to be recognized.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R749.16
【引證文獻(xiàn)】
相關(guān)期刊論文 前1條
1 駢文婷;張敬;楊明銘;;Alzheimer病乳頭體MRI體積測(cè)量研究[J];中國(guó)中西醫(yī)結(jié)合影像學(xué)雜志;2013年04期
，本文編號(hào)：2486223
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