【摘要】：目的·探討中國漢族人群神經(jīng)肽Y(NPY)基因多態(tài)性與精神分裂癥的相關(guān)性。方法·采用Taq Man探針基因分型技術(shù)對(duì)678例精神分裂癥患者(病例組)及685例正常對(duì)照者(對(duì)照組)的NPY基因多態(tài)性(rs16148、rs1859290、rs16147、rs16478)進(jìn)行分型。應(yīng)用SHEsis在線軟件比較各組間的等位基因頻率、基因型頻率、單倍型頻率分布有無差異。結(jié)果·rs16478位點(diǎn)基因型頻率分布在成年起病精神分裂癥(AOS)組和對(duì)照組間存在邊緣統(tǒng)計(jì)學(xué)差異(χ~2=6.66,P=0.036,P_(校正)=0.144)。在隱性模式下,rs1859290位點(diǎn)CC基因型的頻率分布在男性病例組和對(duì)照組間差異有統(tǒng)計(jì)學(xué)意義(P=0.012,OR=0.97,95%CI為0.94~0.99,P_(校正)=0.048)。單倍型CCTA(由rs16148、rs1859290、rs16147、rs16478構(gòu)成)的頻率分布在男性AOS組和對(duì)照組間的差異有統(tǒng)計(jì)學(xué)意義(8.1%vs 13.2%,OR=0.57,P=0.010,P校正=0.040)。結(jié)論·在中國漢族人群中,NPY基因可能是精神分裂癥的易感基因。
[Abstract]:Objective to investigate the relationship between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population. Methods NPY gene polymorphism (rs16148,rs1859290,rs16147,rs16478) in 678 patients with schizophrenia (case group) and 685 normal controls (control group) were typed by Taq Man probe genotyping. SHEsis online software was used to compare whether there were differences in allele frequency, genotypic frequency and haplotype frequency distribution among the three groups. Results there was significant difference in genotypic frequency distribution of rs16478 locus between (AOS) group and control group (蠂 ~ 2 鈮，

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