【摘要】：目的探究藍光對SD大鼠焦慮、抑郁及睡眠的影響。方法動物分為正常光照組、低(100 lx)、中(300 lx)和高(500 lx)劑量藍光照射組;剝奪藍光對照組和剝奪藍光組6個組,低、中、高3個劑量照射組藍光照射28 d,每天1 h,剝奪藍光組采用去除藍光的白光照明飼養(yǎng)28 d。用高架十字迷宮實驗、強迫游泳實驗及戊巴比妥鈉睡眠實驗分別觀察藍光照射及去除藍光對大鼠焦慮、抑郁及睡眠的影響。結果高架十字迷宮實驗各項指標組間差異無顯著性。藍光照射中劑量組動物強迫游泳實驗中不動時間減少(P0.05),剝奪藍光導致不動時間延長(P0.05);中劑量組在戊巴比妥鈉睡眠實驗中大鼠睡眠時間延長(P0.05),剝奪藍光對戊巴比妥鈉睡眠實驗結果無明顯影響。結論藍光照射不影響大鼠的焦慮狀態(tài),300 lx藍光照射對大鼠有抗抑郁及促進睡眠的作用,而剝奪藍光會導致大鼠抑郁。
[Abstract]:Objective to investigate the effects of blue light on anxiety, depression and sleep in SD rats. Methods the animals were divided into three groups: normal irradiation group, low dose blue irradiation group (100 lx), 300 lx) and high dose blue light irradiation (500 lx). Blue light deprivation control group and blue light deprivation group 6 groups, low, middle and high doses of blue light irradiation for 28 days, 1 hour per day, the deprivation group was fed with white light without blue light for 28 d. The effects of blue light irradiation and removal of blue light on anxiety, depression and sleep in rats were observed by viaduct maze test, forced swimming test and pentobarbital sodium sleep test. Results there was no significant difference in the indexes of elevated maze test. In the middle dose group of blue light irradiation, the immobility time was decreased in the forced swimming experiment (P0.05), and the immobility time was prolonged when the blue light was deprived (P0.05). In the middle dose group, the sleep time was prolonged in the pentobarbital sodium sleep experiment (P0.05), and the results of pentobarbital sodium sleep test were not affected by blue light deprivation. Conclusion Blue light irradiation does not affect the anxiety state of rats. 300 lx blue light irradiation has antidepressant and sleep-promoting effects on rats, while deprivation of blue light can lead to depression in rats.
【作者單位】： 北京大學公共衛(wèi)生學院;
【基金】：北京大學"985工程"臨床醫(yī)院合作專項(2013-3-01)
【分類號】：R749
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本文編號：2466837