2~3歲孤獨(dú)譜系障礙兒童的腦彌散張量成像研究
發(fā)布時(shí)間:2019-04-15 19:49
【摘要】:目的:對(duì)比分析2~3歲孤獨(dú)譜系障礙兒童與發(fā)育遲緩(DD)兒童的腦白質(zhì)纖維結(jié)構(gòu)的異常。方法:對(duì)60例符合美國精神障礙診斷和統(tǒng)計(jì)手冊(cè)第4版(修訂版)(DSM-Ⅳ-TR)診斷標(biāo)準(zhǔn)的孤獨(dú)譜系障礙兒童(病例組)和35例年齡、性別、智商與之相匹配的發(fā)育障礙兒童(對(duì)照組)進(jìn)行腦彌散張量成像掃描,應(yīng)用基于體素的分析法比較兩組全腦白質(zhì)纖維結(jié)構(gòu)的異常。結(jié)果:與對(duì)照組相比,孤獨(dú)譜系障礙兒童胼胝體、后側(cè)扣帶、邊緣葉、左側(cè)顳下區(qū)、左側(cè)顳中區(qū)、布羅德曼8區(qū)、右側(cè)眶額葉下部、右側(cè)額中區(qū)、右側(cè)額上區(qū)等處白質(zhì)各向異性值顯著增大(P0.001,k≥10)。結(jié)論:與DD兒童相比,2~3歲孤獨(dú)譜系障礙兒童呈現(xiàn)出多處腦白質(zhì)纖維結(jié)構(gòu)的異常,且與青少年期、成年期患者的異常形式有差異。
[Abstract]:Aim: to compare the structural abnormalities of white matter fibers between 3-year-old children with solitary pedigree disorders and (DD) children with developmental retardation. Methods: 60 children with autism pedigree disorders (DSM- 鈪,
本文編號(hào):2458442
[Abstract]:Aim: to compare the structural abnormalities of white matter fibers between 3-year-old children with solitary pedigree disorders and (DD) children with developmental retardation. Methods: 60 children with autism pedigree disorders (DSM- 鈪,
本文編號(hào):2458442
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