【摘要】：目的采取線索反應(yīng)模式及靜息態(tài)功能連接的方法，利用功能磁共振成像(fMRI)探索與海洛因成癮者復(fù)吸的腦區(qū)功能定位，確定與環(huán)境因素導(dǎo)致復(fù)吸的相關(guān)腦區(qū)，重點了解后扣帶回在海洛因成癮中的功能作用。 方法海洛因成癮者和對照者各15例，使用3.0T Philips Power Station MR成像及功能磁共振視頻刺激系統(tǒng)：（1）采用線索誘發(fā)模式，使用E-Prime編輯海洛因使用視頻，在觀看海洛因相關(guān)視頻同步進行功能磁共振掃描，利用事件相關(guān)功能磁共振及使用獨立成分分析的方法，了解海洛因成癮者在海洛因相關(guān)場景刺激下，后扣帶回及相關(guān)腦區(qū)的激活與正常被試的差異；（2）采用靜息態(tài)模式，利用功能連接的方法，以后扣帶回為感興趣區(qū)，分別與全腦進行功能連接分析，了解海洛因成癮者在靜息狀態(tài)下，后扣帶回功能連接情況及與正常被試的差異。 結(jié)果（1）海洛因成癮組與正常對照組相比，在相關(guān)線索的刺激下，雙側(cè)前額葉，左前扣帶回，，雙側(cè)后扣帶回，左側(cè)頂葉，左側(cè)顳下回的激活顯著降低；雙側(cè)伏核、右側(cè)海馬以及枕葉的激活明顯增強；（2）當以左側(cè)后扣帶回作為感興趣區(qū)做全腦的功能連接時發(fā)現(xiàn)，相比較與對照組，海洛因成癮組左側(cè)后扣帶回與右側(cè)顳葉的功能連接增強，與右側(cè)額葉、丘腦以及左側(cè)頂葉的功能連接明顯降低；選取右側(cè)后扣帶回作為感興趣區(qū)進行全腦功能連接時，海洛因成癮組右側(cè)后扣帶回與左側(cè)額葉、左側(cè)頂葉以及左側(cè)丘腦的功能連接明顯低于正常對照組（P＜0.05）； 結(jié)論（1）海洛因成癮者，在線索誘發(fā)及靜息狀態(tài)下，后扣帶回功能均出現(xiàn)異常，后扣帶回參與了海洛因成癮者獎賞系統(tǒng)的組成，與海洛因成癮的產(chǎn)生，維持，復(fù)吸密切相關(guān)。（2）在線索誘發(fā)情況下，海洛因成癮者獎賞系統(tǒng)及相關(guān)腦區(qū)明顯激活，獎賞系統(tǒng)等相關(guān)腦區(qū)共同參與了場景誘導(dǎo)的海洛因復(fù)吸。
[Abstract]:Objective to explore the functional localization of brain regions in heroin addicts with functional magnetic resonance imaging (fMRI) using the methods of cue response pattern and resting functional connection, so as to determine the brain regions related to environmental factors leading to relapse, and to explore the functional localization of brain regions associated with relapse of heroin addicts by functional magnetic resonance imaging (fMRI). To understand the function of posterior cingulate gyrus in heroin addiction. Methods heroin addicts (n = 15) and control group (n = 15) were treated with 3.0T Philips Power Station MR imaging and functional magnetic resonance video stimulation system. (1) lead-induced mode was used to edit heroin use video using E-Prime. After watching heroin-related videos synchronously performing functional magnetic resonance scans, using event-related functional magnetic resonance imaging and independent component analysis, we found out that heroin addicts were stimulated by heroin-related scenes. The activation of posterior cingulate gyrus and related brain areas was different from that of normal subjects. (2) using the static mode and the functional connection method, the cingulate gyrus is the region of interest, and the whole brain is analyzed to understand the heroin addict in the resting state, and then the cingulate gyrus is the region of interest, and the whole brain is used to analyze the functional connection of the heroin addict. Functional connection of posterior cingulate gyrus and its difference with normal subjects. Results (1) compared with the normal control group, the activation of bilateral frontal lobe, left anterior cingulate gyrus, bilateral posterior cingulate gyrus, left parietal lobe and left inferior temporal gyrus decreased significantly in heroin addiction group. The activation of bilateral nucleus accumbens, right hippocampus and occipital lobe was significantly increased. (2) when the left posterior cingulate gyrus was used as the functional connection of the whole brain, compared with the control group, the functional connection between the left posterior cingulate gyrus and the right temporal lobe and the right frontal lobe was enhanced in the heroin addicted group. The functional connection of thalamus and left parietal lobe decreased significantly. The functional connection between right posterior cingulate gyrus and left frontal lobe, left parietal lobe and left thalamus in heroin addicted group was significantly lower than that in normal control group (P < 0.05) when the right posterior cingulate gyrus was selected as the whole brain functional connection of the region of interest (P < 0.05). Conclusion (1) the function of the posterior cingulate gyrus is abnormal in both the cue-induced and resting state. The posterior cingulate gyrus is involved in the composition of the reward system of heroin addicts, and it is associated with the production and maintenance of heroin addiction, and that the posterior cingulate gyrus is involved in the formation and maintenance of heroin addiction. Relapse is closely related. (2) in the case of cue-induced heroin addicts, the reward system and the related brain regions are obviously activated, and the reward system and other related brain regions participate in the scene-induced heroin relapse.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.6

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