【摘要】：目的：以創(chuàng)傷后應(yīng)激障礙患者為載體,功能磁共振成像為技術(shù)手段,分析在靜息狀態(tài)下電針治療創(chuàng)傷后應(yīng)激障礙患者腦區(qū)的局部一致性特點,探討電針治療創(chuàng)傷后應(yīng)激障礙的中樞整合機制。 方法：納入12例創(chuàng)傷后應(yīng)激障礙患者用電針治療12周,對創(chuàng)傷后應(yīng)激障礙患者治療前、治療6周后、治療12周后使用臨床監(jiān)測量表、漢密爾頓抑郁量表、漢密爾頓焦慮量表進行評定。同時在電針治療前后利用局部一致性方法檢測靜息狀態(tài)下12例創(chuàng)傷后應(yīng)激障礙患者的大腦局部一致性差異,評價治療方案的臨床療效,并在此基礎(chǔ)上分析針刺治療創(chuàng)傷后應(yīng)激障礙的中樞整合機制。 結(jié)果：①該試驗完成情況良好,電針治療創(chuàng)傷后應(yīng)激障礙療效確切。臨床監(jiān)測量表、漢密爾頓抑郁量表、漢密爾頓焦慮量表評分治療前后相比均有統(tǒng)計學(xué)意義(P0.05)。②與電針治療前相比,在電針治療后患者影像學(xué)顯示左側(cè)額中回、左側(cè)顳上回、右側(cè)額下回、右側(cè)顳中回、右側(cè)島葉、右側(cè)丘腦、扣帶回、海馬旁回、舌回、楔葉、前楔葉、尾狀核、小腦等腦區(qū)局部一致性增高(P0.05,校正)。 結(jié)論：電針治療創(chuàng)傷后應(yīng)激障礙患者具有一定效果,其有效機理可能與調(diào)節(jié)額葉、顳葉、島葉、枕葉、邊緣系統(tǒng)和小腦等腦區(qū)構(gòu)成的神經(jīng)環(huán)路有關(guān)。
[Abstract]:Objective: to analyze the characteristics of local consistency in the brain region of patients with post-traumatic stress disorder (PTSD) treated by electroacupuncture under resting condition, using functional magnetic resonance imaging (fMRI) as the carrier. To explore the central integration mechanism of electroacupuncture for post traumatic stress disorder (PTSD). Methods: twelve patients with post-traumatic stress disorder were treated with electroacupuncture for 12 weeks. The patients with post-traumatic stress disorder were treated with clinical monitoring scale and Hamilton depression scale before, after 6 weeks and 12 weeks after treatment. Hamilton anxiety scale was evaluated. At the same time, the local consistency of 12 patients with post-traumatic stress disorder (PTSD) was detected by local consistency method before and after electroacupuncture treatment, and the clinical effect of the treatment was evaluated. On this basis, the central integration mechanism of acupuncture for post-traumatic stress disorder was analyzed. Results: 1 the experiment was completed well and the effect of electroacupuncture on post-traumatic stress disorder was definite. The clinical monitoring scale, Hamilton depression scale and Hamilton anxiety scale score were statistically significant before and after treatment (P0.05). The local consistency of left superior temporal gyrus, right inferior frontal gyrus, right middle temporal gyrus, right insular lobe, right thalamus, cingulate gyrus, perihippocampal gyrus, lingual gyrus, cuneate lobe, anterior cuneate lobe, caudate nucleus and cerebellum were increased (P0.05, corrected). Conclusion: electroacupuncture is effective in the treatment of post-traumatic stress disorder, and its effective mechanism may be related to the regulation of neural loops in frontal lobe, temporal lobe, island lobe, occipital lobe, limbic system and cerebellum.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R749.5;R246.6

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