【摘要】：目的:探討帕羅西汀對急性腦梗死后抑郁患者抑郁狀態(tài)及神經(jīng)功能恢復(fù)的影響。方法:回顧性分析我院108例急性腦梗死后抑郁患者資料,按照用藥不同分為觀察組(54例)和對照組(54例)。兩組患者均給予脫水、活血化瘀、抗凝、降纖等常規(guī)治療。在此基礎(chǔ)上,觀察組患者給予鹽酸帕羅西汀片20 mg,每天1次;對照組患者給予鹽酸舍曲林片50 mg,每天1次。兩組療程均為4周。觀察兩組患者抑郁緩解情況和神經(jīng)功能恢復(fù)情況,比較治療前后漢密爾頓抑郁量表(HAMD)和改良的愛丁堡-斯堪的納維亞卒中量表(MESSS)評分及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者抑郁緩解總有效率(70.37%)和神經(jīng)功能恢復(fù)總有效率(66.67%)均顯著高于對照組(分別為38.89%、40.74%),差異均有統(tǒng)計學(xué)意義(P0.05)。治療前,兩組患者HAMD和MESSS評分比較,差異均無統(tǒng)計學(xué)意義(P0.05);治療后,兩組患者HAMD和MESSS評分均顯著低于同組治療前,且觀察組顯著低于同期對照組,差異均有統(tǒng)計學(xué)意義(P0.05)。治療期間兩組患者均未見明顯不良反應(yīng)發(fā)生。結(jié)論:帕羅西汀治療急性腦梗死后抑郁療效較好,可以有效緩解患者的抑郁癥狀,間接促進(jìn)其神經(jīng)功能的恢復(fù),對急性腦梗死患者預(yù)后有積極作用,安全性亦較好。
[Abstract]:Objective: to investigate the effect of paroxetine on depression and recovery of nerve function in patients with depression after acute cerebral infarction. Methods: the data of 108 patients with depression after acute cerebral infarction in our hospital were retrospectively analyzed and divided into observation group (54 cases) and control group (54 cases). Both groups were given routine treatment such as dehydration, promoting blood circulation and removing blood stasis, anticoagulation, defibrillation and so on. On this basis, the patients in the observation group were given paroxetine hydrochloride once a day for 20 mg, and the patients in the control group were given sertraline hydrochloride tablets once a day for 50 mg,. The course of treatment was 4 weeks in both groups. Depression relief and neurological function recovery were observed in two groups. (HAMD) and (MESSS) scores of modified Edinburgh-Scandinavia Stroke scale and adverse reactions were compared before and after treatment. Results: the total effective rate of depression relief (70.37%) and the total effective rate of nerve function recovery (66.67%) in the observation group were significantly higher than those in the control group (38.89%, 40.74%, respectively), and the difference was statistically significant (P0.05). Before treatment, there was no significant difference in HAMD and MESSS scores between the two groups (P0.05). After treatment, the HAMD and MESSS scores of the two groups were significantly lower than those of the same group before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred in both groups during treatment. Conclusion: paroxetine is effective in the treatment of depression after acute cerebral infarction, which can effectively relieve the depression symptoms, indirectly promote the recovery of neurological function, and has a positive effect on the prognosis and safety of patients with acute cerebral infarction.
【作者單位】： 運城市中心醫(yī)院藥學(xué)部;運城市中心醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.33;R749.4

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