【摘要】：目的：觀察地黃益腦膠囊治療腎虛血瘀型血管性癡呆的臨床療效。 方法：本課題臨床研究采用單盲,隨機(jī)對(duì)照試驗(yàn),通過(guò)樣本估算確定樣本含量為60例,隨機(jī)分為地黃益腦膠囊治療組40例,口服地黃益腦膠囊(熟地黃、生地黃、淮山藥、蔓荊子、枸杞子、茯苓、黃精、玉竹、決明子、川芎、山茱萸、當(dāng)歸、夜交滕、酸棗仁、丹皮、炙甘草)治療,對(duì)照組20例口服腦復(fù)康治療。療程為2個(gè)月。本研究對(duì)比了兩組藥物的臨床總療效,選擇了MMSE,HDS和FAQ量表進(jìn)行神經(jīng)心理、認(rèn)知能力的檢測(cè),觀察治療前后血液流變學(xué)指標(biāo)變化和藥物的毒副反應(yīng),對(duì)比治療前后中醫(yī)癥狀的改變,分析地黃益腦膠囊對(duì)血管性癡呆療效和患者年齡的相關(guān)性。 結(jié)果：地黃益腦膠囊對(duì)腎虛血瘀型血管性癡呆的患者有肯定的療效,益智作用明顯,總有效率達(dá)77.5%,腦復(fù)康對(duì)照組總有效率50.00%,經(jīng)統(tǒng)計(jì)學(xué)處理,兩組有顯著性差異(P0.05)。且對(duì)中醫(yī)癥狀的改善效果優(yōu)于對(duì)照組,尤其是腰膝酸軟,耳鳴耳聾,尿后余瀝或失禁,肢體麻木,判斷力減退,識(shí)別力減退,計(jì)算力減退,人格障礙以及舌脈更明顯(P0.01,P0.05),經(jīng)過(guò)MMSE,HDS和FAQ量表神經(jīng)心理、認(rèn)知能力的檢測(cè),結(jié)果治療后HDS、FAQ和MMSE積分值均有改善,但治療組效果更明顯(P0.01)且治療組MMSE積分明顯高于對(duì)照組(P0.05),對(duì)血液流變的作用,治療組治療后各項(xiàng)指標(biāo)均有顯著改善(P0.01,P0.05),而對(duì)照組治療前后均無(wú)明顯差異,可見(jiàn)地黃益腦膠囊具有良好的活血化瘀作用。地黃益腦膠囊治療血管性癡呆的療效和患者年齡無(wú)關(guān),廣泛適用于51-82歲之間的老年前期及老年期患者,其療效和腦血管疾病分期有關(guān),對(duì)腦血管病早期的癡呆療效更好。通過(guò)對(duì)該藥的急性毒性和長(zhǎng)期毒性實(shí)驗(yàn)觀察,未發(fā)現(xiàn)毒副反應(yīng)。 結(jié)論：地黃益腦膠囊治療腎虛血瘀型血管性癡呆療效確切。
[Abstract]:Objective: to observe the clinical effect of Dihuang Yinao capsule on vascular dementia with kidney deficiency and blood stasis. Methods: a single blind, randomized controlled trial was used to determine the sample size of 60 cases. The patients were randomly divided into treatment group (40 cases) treated with Rehmannia yinao capsule (Rehmannia glutinosa), Rehmannia glutinosa (Rehmannia glutinosa), Chinese yam (Dioscorea sinensis). Vitex chinensis, Fructus Lycii, Poria cocos, Yellow extract, Yudu, Cassia seed, Ligusticum chuanxiong, Cornus officinalis, Angelica sinensis, Niangjiao Teng, Zizyphus jujuba, Cortex Salvia, Radix Glycyrrhiza) were treated. The course of treatment was 2 months. In this study, we compared the total clinical efficacy of the two groups of drugs, selected MMSE,HDS and FAQ scale to test the neuropsychological and cognitive ability, observed the changes of hemorheology indexes and side effects of the drugs before and after treatment. To compare the changes of TCM symptoms before and after treatment, and to analyze the correlation between the curative effect of Dihuang Yinao capsule on vascular dementia and the age of the patients. Results: Dihuang Yinao capsule had definite curative effect on vascular dementia with kidney deficiency and blood stasis type. The total effective rate was 77.5%, and the total effective rate was 77.5%. The total effective rate of Naofukang control group was 50.00g, which was treated by statistics. There was significant difference between the two groups (P0.05). The improvement effect of TCM symptoms was better than that of the control group, especially in the patients with weak waist and knee, tinnitus and deafness, residual urine loss or incontinence, limb numbness, loss of judgment, decreased recognition, decreased computational power, personality disorder and more obvious tongue pulse (P0.01). P05), the scores of HDS,FAQ and MMSE were improved after the treatment of MMSE,HDS and FAQ, after the test of neuropsychological and cognitive ability, the scores of HDS,FAQ and MMSE were improved after treatment. But the effect of the treatment group was more obvious (P0.01) and the MMSE score of the treatment group was significantly higher than that of the control group (P0.05). In the control group, there was no significant difference before and after treatment, so Dihuang Yinao capsule had a good effect of promoting blood circulation and removing blood stasis. The therapeutic effect of Dihuang Yinao capsule on vascular dementia is not related to the age of the patients. It is widely used in the aged patients between 51 and 82 years of age. The curative effect is related to the stages of cerebrovascular disease, and the effect is better for the early stage of cerebrovascular disease dementia. The acute toxicity and long-term toxicity of the drug were observed and no side effects were found. Conclusion: Dihuang Yinao capsule is effective in the treatment of vascular dementia with kidney deficiency and blood stasis.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R749.13

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本文編號(hào)：2400615