【摘要】：目的:觀察甜夢(mèng)口服液聯(lián)合帕羅西汀治療圍絕經(jīng)期抑郁癥的療效和安全性。方法:85例圍絕經(jīng)期抑郁癥女性患者隨機(jī)分為對(duì)照組(41例)和觀察組(44例)。對(duì)照組患者每日早餐后口服鹽酸帕羅西汀片20 mg,每日1次;觀察組患者在對(duì)照組治療的基礎(chǔ)上給予甜夢(mèng)口服液10 mL,每日早晚各1次。兩組均連用8周。觀察兩組患者的臨床療效,治療前后圍絕經(jīng)期綜合量表(Kupperman)評(píng)分、漢密爾頓抑郁量表(HAMD)評(píng)分、腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)水平及不良反應(yīng)發(fā)生情況。結(jié)果:對(duì)照組和觀察組各有1、2例患者失訪。兩組患者總有效率、不良反應(yīng)發(fā)生率比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者Kupperman評(píng)分、HAMD評(píng)分均顯著低于同組治療前,隨時(shí)間延長(zhǎng)逐漸降低,且觀察組患者治療第8周時(shí)Kupperman評(píng)分、治療第2周時(shí)HAMD評(píng)分均顯著低于對(duì)照組;兩組患者BDNF水平均顯著高于同組治療前,隨時(shí)間延長(zhǎng)逐漸升高,且觀察組顯著高于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05或P0.01)。結(jié)論:甜夢(mèng)口服液聯(lián)合帕羅西汀治療圍絕經(jīng)期抑郁癥的療效和安全性與單用帕羅西汀相當(dāng),但在改善癥狀、升高BDNF方面優(yōu)于單用帕羅西汀。
[Abstract]:Objective: to observe the efficacy and safety of Tianmeng oral liquid combined with paroxetine in the treatment of postmenopausal depression. Methods: 85 female patients with peri-menopausal depression were randomly divided into control group (41 cases) and observation group (44 cases). The patients in the control group were treated with paroxetine hydrochloride once a day for 20 mg, after breakfast, while the patients in the observation group were treated with sweet dream oral liquid once a day for 10 mL,. Both groups were treated for 8 weeks. The clinical efficacy, (Kupperman) score, (HAMD) score of Hamilton depression scale, the level of brain-derived neurotrophic factor (BDNF) and the incidence of adverse reactions were observed before and after treatment. Results: there were 12 cases in control group and 2 cases in observation group. There was no significant difference in the total effective rate and the incidence of adverse reactions between the two groups (P0.05). After treatment, the Kupperman score and HAMD score of the two groups were significantly lower than those of the same group before treatment, and gradually decreased with the prolongation of time. The Kupperman score of the observation group was significantly lower than that of the control group at the 8th week of treatment and the HAMD score at the second week of treatment. The level of BDNF in the two groups was significantly higher than that in the same group before treatment, and gradually increased with the prolongation of time, and the observation group was significantly higher than the control group, the difference was statistically significant (P0.05 or P0.01). Conclusion: the efficacy and safety of Tianmeng oral liquid combined with paroxetine in the treatment of peri-menopausal depression is similar to that of paroxetine alone, but it is superior to paroxetine alone in improving symptoms and increasing BDNF.
【作者單位】： 咸寧市中心醫(yī)院藥劑科;咸寧市中心醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R749.4

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