土黨參多糖對半乳糖聯(lián)合三氯化鋁致阿爾茨海默病小鼠腦損傷的影響
發(fā)布時間：2018-12-24 09:10
【摘要】：目的研究土黨參多糖(CJP)對D-半乳糖聯(lián)合三氯化鋁所致小鼠腦神經(jīng)損傷的影響。方法采用皮下注射D-半乳糖聯(lián)合灌胃三氯化鋁造成小鼠神經(jīng)系統(tǒng)損傷。以小鼠學習記憶成績、腦組織中的丙二醛(MDA)、一氧化氮(NO)、谷胱甘肽(GSH)及乙酰膽堿(Ach)等含量變化為考察指標,考察CJP對腦損傷小鼠的影響。結(jié)果與模型組比較,CJP能改善腦損傷小鼠的學習記憶,提高腦中GSH、超氧化物歧化酶(SOD)含量,降低腦中NO和MDA水平。結(jié)論 CJP對D-半乳糖聯(lián)合三氯化鋁所致的小鼠腦損傷有一定的改善作用。
[Abstract]:Objective to study the effect of Polysaccharide (CJP) of Codonopsis pilosula on brain nerve injury induced by D-galactose and aluminum trichloride in mice. Methods the nerve system injury was induced by subcutaneous injection of D-galactose and intragastric administration of aluminum chloride. The changes of malondialdehyde (MDA), nitric oxide (MDA), glutathione (GSH) and acetylcholine (Ach) in brain tissue were used as indexes to investigate the effect of CJP on brain injury in mice. Results compared with the model group, CJP could improve the learning and memory of brain injury mice, increase the (SOD) content of GSH, superoxide dismutase, and decrease the levels of NO and MDA in the brain. Conclusion CJP can improve the brain injury induced by D-galactose and aluminum trichloride in mice.
【作者單位】： 阜陽市食品藥品監(jiān)督管理局;貴州省中國科學院天然產(chǎn)物化學重點實驗室;
【基金】：國家自然科學基金資助課題(No.81160513)
【分類號】：R749.16
本文編號：2390442
[Abstract]:Objective to study the effect of Polysaccharide (CJP) of Codonopsis pilosula on brain nerve injury induced by D-galactose and aluminum trichloride in mice. Methods the nerve system injury was induced by subcutaneous injection of D-galactose and intragastric administration of aluminum chloride. The changes of malondialdehyde (MDA), nitric oxide (MDA), glutathione (GSH) and acetylcholine (Ach) in brain tissue were used as indexes to investigate the effect of CJP on brain injury in mice. Results compared with the model group, CJP could improve the learning and memory of brain injury mice, increase the (SOD) content of GSH, superoxide dismutase, and decrease the levels of NO and MDA in the brain. Conclusion CJP can improve the brain injury induced by D-galactose and aluminum trichloride in mice.
【作者單位】： 阜陽市食品藥品監(jiān)督管理局;貴州省中國科學院天然產(chǎn)物化學重點實驗室;
【基金】：國家自然科學基金資助課題(No.81160513)
【分類號】：R749.16
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