【摘要】：目的:研究頸動脈狹窄與認(rèn)知功能障礙及血清超敏C反應(yīng)蛋白的相關(guān)性。方法:采用彩色多普勒血管超聲將67例頸動脈狹窄患者分為頸動脈輕度狹窄組(n=22例,動脈血管內(nèi)徑縮小30%)、頸動脈中度狹窄組(n=25例,動脈血管內(nèi)徑縮小30%~70%)和頸動脈重度狹窄組(n=20例,動脈血管內(nèi)徑縮小70%)。同期選取25例無頸動脈狹窄門診正常體檢者作為對照組。采用簡易精神狀態(tài)量表(MMSE)和Mo CA檢測頸動脈輕度狹窄組、頸動脈中度狹窄組、頸動脈重度狹窄組患者認(rèn)知功能;采用酶聯(lián)免疫吸附(ELISA)法檢測頸動脈輕度狹窄組、頸動脈中度狹窄組、頸動脈重度狹窄組患者及對照組血清hs-CRP表達(dá)水平;根據(jù)Mo CA將頸動脈狹窄患者分為認(rèn)知功能障礙組及非認(rèn)知功能障礙組,采用ELISA法檢測兩組患者血清hs-CRP表達(dá)水平。結(jié)果:1中度狹窄組患者M(jìn)MSE評分、定向力、即刻回憶力及延遲回憶力均明顯低于輕度狹窄組(P0.05),而重度狹窄組患者M(jìn)MSE評分、定向力、即刻回憶力及延遲回憶力均明顯低于中度狹窄組(P0.05),各組頸動脈狹窄組患者在語言能力及注意計(jì)算力等方面比較無顯著差異性(P0.05);2中度狹窄組患者M(jìn)o CA總分、視空間與執(zhí)行功能、延遲回憶、定向力等均明顯低于輕度狹窄組(P0.05),而重度狹窄組患者M(jìn)o CA總分、視空間與執(zhí)行功能、延遲回憶、定向力等均明顯低于中度狹窄組(P0.05),各組頸動脈狹窄組患者在命名、注意力、語言、抽象等方面比較無顯著差異性(P0.05);3各組狹窄組患者血清hs-CRP表達(dá)水平均明顯高于對照組(P0.05),且隨頸動脈狹窄程度加重患者血清hs-CRP表達(dá)水平明顯升高(P0.05);4 67例頸動脈狹窄患者經(jīng)Mo CA評分共分為認(rèn)知功能障礙組(n=37例)與非認(rèn)知功能障礙組(n=30例),認(rèn)知功能障礙組患者血清hs-CRP表達(dá)水平明顯高于非認(rèn)知功能障礙組(P0.05);5 MMSE評分及Mo CA評分與頸動脈狹窄程度呈負(fù)相關(guān)性關(guān)系(r1=-0.374,r2=-0.365,P0.05),血清hs-CRP表達(dá)水平與頸動脈狹窄程度呈正相關(guān)性關(guān)系(r3=0.402,P0.05)。結(jié)論:頸動脈狹窄與認(rèn)知功能障礙及hs-CRP呈正相關(guān)性關(guān)系。頸動脈狹窄程度越重,認(rèn)知功能障礙損害越明顯;頸動脈狹窄程度越重,血清hs-CRP表達(dá)水平越高;認(rèn)知功能障礙越重,血清hs-CRP表達(dá)水平越高。
[Abstract]:Objective: to study the relationship between carotid artery stenosis and cognitive impairment and serum hypersensitive C reactive protein. Methods: 67 patients with carotid artery stenosis were divided into two groups by color Doppler ultrasound: mild carotid stenosis group (n = 22), carotid artery stenosis group (n = 25), carotid artery stenosis group (n = 22) and carotid artery stenosis group (n = 25). The arterial diameter was reduced by 30% (70%) and in the group of severe carotid stenosis (n = 20, the diameter of artery was reduced by 70%). At the same time, 25 normal subjects without carotid artery stenosis were selected as control group. The cognitive function of patients with mild stenosis of carotid artery, moderate stenosis of carotid artery and severe stenosis of carotid artery were measured by (MMSE) and Mo CA. The expression of serum hs-CRP in patients with mild stenosis of carotid artery, moderate stenosis of carotid artery, severe stenosis of carotid artery and control group were detected by enzyme-linked immunosorbent assay (ELISA). According to Mo CA, the patients with carotid artery stenosis were divided into two groups: cognitive dysfunction group and non-cognitive dysfunction group. The expression of serum hs-CRP was detected by ELISA method. Results: 1the MMSE score, orientation, immediate recall and delayed recall in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while MMSE score and orientation in severe stenosis group were significantly lower than those in mild stenosis group. Immediate recall and delayed recall were significantly lower than those of moderate stenosis group (P0.05). There was no significant difference in language ability and attention computing ability in carotid artery stenosis group (P0.05). 2the total score of Mo CA, visual space and executive function, delayed recall, orientation in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while Mo CA total score, visual space and executive function, delayed recall in severe stenosis group were significantly lower than those in mild stenosis group (P0.05). Orientation was significantly lower than that in moderate stenosis group (P0.05). There was no significant difference in naming, attention, language, abstraction and other aspects in carotid artery stenosis group (P0.05). 3The expression of serum hs-CRP in the patients with stenosis was significantly higher than that in the control group (P0.05), and the expression of serum hs-CRP was significantly increased with the severity of carotid artery stenosis (P0.05). 467 patients with carotid artery stenosis were divided into cognitive dysfunction group (n = 37) and non-cognitive dysfunction group (n = 30) by Mo CA score. The level of serum hs-CRP expression in patients with cognitive dysfunction was significantly higher than that in patients without cognitive dysfunction (P0.05). 5 there was a negative correlation between MMSE score and Mo CA score and the degree of carotid artery stenosis (R1 + -0.374). The expression of hs-CRP in serum was positively correlated with the degree of carotid stenosis (R3n0.402) (P0.05). Conclusion: carotid stenosis is positively correlated with cognitive impairment and hs-CRP. The more severe the carotid artery stenosis, the more obvious the cognitive impairment; the more severe the carotid artery stenosis, the higher the level of serum hs-CRP expression; the more serious the cognitive dysfunction, the higher the level of serum hs-CRP expression.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R749.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 朱詠新;周維智;劉曉紅;陳生弟;;癡呆患者血漿凝血及炎性因子變化的相關(guān)性研究[J];腦與神經(jīng)疾病雜志;2008年05期

2 顧萍;杜宏;邵加慶;蔣衛(wèi)民;張凱;;阿托伐他汀對不同階段血管性認(rèn)知功能障礙患者認(rèn)知功能及血脂的影響[J];中華老年心腦血管病雜志;2010年01期

3 陳小容;聶本剛;;阿托伐他汀鈣對血管性認(rèn)知障礙合并高脂血癥患者的血脂及認(rèn)知功能的影響[J];中國全科醫(yī)學(xué);2009年15期

4 王帥;談躍;;腦白質(zhì)病變與輕度認(rèn)知功能障礙的研究進(jìn)展[J];醫(yī)學(xué)綜述;2010年23期

5 中國防治認(rèn)知功能障礙專家共識專家組;;中國防治認(rèn)知功能障礙專家共識[J];中華內(nèi)科雜志;2006年02期

6 蘆林龍;馮濤;劉萍;張璇;王雪梅;王擁軍;;急性缺血性卒中患者腦白質(zhì)病變與認(rèn)知功能障礙的相關(guān)性研究[J];中國卒中雜志;2010年11期

，

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