【摘要】：目的探討帕羅西汀聯(lián)合氟哌噻噸美利曲辛治療腦卒中后重性抑郁障礙的臨床應(yīng)用價(jià)值。方法選取2015年2月至2017年10月期間我院收治的96例腦卒中后重性抑郁障礙患者作為研究對(duì)象,利用隨機(jī)數(shù)字表法將其分為研究組、對(duì)照組,每組48例。對(duì)照組腦卒中后重性抑郁障礙患者在常規(guī)治療基礎(chǔ)上加用氟哌噻噸美利曲辛,20 mg/次,每日2次,連續(xù)服用28 d;研究組腦卒中后重性抑郁障礙患者在常規(guī)治療基礎(chǔ)上加用帕羅西汀,25 mg/次,1次/d,連續(xù)給藥28 d,氟哌噻噸美利曲辛給藥同對(duì)照組。結(jié)果兩組腦卒中后重性抑郁障礙患者治療完成率均為100.00%。兩組腦卒中后重性抑郁障礙患者治療前HAMD、NIHSS、SF-36、SCL-90量表評(píng)分對(duì)比無顯著差異(P0.05),治療后研究組HAMD、SCL-90、NIHSS量表評(píng)分較之前下降幅度以及SF-36量表評(píng)分上升幅度均優(yōu)于對(duì)照組(P均0.05);兩組各項(xiàng)藥物相關(guān)不良反應(yīng)發(fā)生率對(duì)比差異均無統(tǒng)計(jì)學(xué)意義,P均0.05。結(jié)論應(yīng)用帕羅西汀、氟哌噻噸美利曲辛聯(lián)合治療腦卒中后重性抑郁障礙具有較為理想的應(yīng)用效果,有利于保障患者生活質(zhì)量、身心健康。
[Abstract]:Objective to investigate the clinical value of paroxetine combined with droperazone metriaxine in the treatment of post-stroke depressive disorder. Methods from February 2015 to October 2017, 96 patients with post-stroke depressive disorder were selected and divided into study group (n = 48) and control group (n = 48). In the control group, patients with severe depressive disorder after stroke were treated with droperazidone metriaxine for 20 mg/, twice a day, on the basis of routine treatment. The patients in the study group were treated with paroxetine, 25 mg/, once a day for 28 days. Results the complete rate of treatment in patients with severe depression after stroke was 100.00g. There was no significant difference in the scores of HAMD,NIHSS,SF-36,SCL-90 scale between the two groups before treatment (P0.05), but the decrease of HAMD,SCL-90,NIHSS scale and the increase of SF-36 scale in the study group were better than those in the control group (P0.05). There was no significant difference in the incidence of various drug related adverse reactions (P < 0.05). Conclusion the application of paroxetine and droperazone metriaxine in the treatment of post-stroke depressive disorder has an ideal effect, which is beneficial to the protection of patients' quality of life and physical and mental health.
【作者單位】： 沈陽(yáng)醫(yī)學(xué)院附屬中心醫(yī)院神經(jīng)內(nèi)四科;沈陽(yáng)醫(yī)學(xué)院附屬中心醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R743.3;R749.4

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