【摘要】：目的:探討艾司西酞普蘭治療國內(nèi)驚恐障礙患者的療效和安全性。方法:應(yīng)用Meta分析對12項艾司西酞普蘭對照研究文獻(xiàn)進(jìn)行再分析,評價其合并效應(yīng)量大小和綜合顯著性檢驗。結(jié)果:艾司西酞普蘭治療前后的自身對照顯示,艾司西酞普蘭治療驚恐障礙2周后療效變化顯著(Tau2=4.06;95%CI:1.92,2.28;Z=5.90;P0.01)。艾司西酞普蘭與對照藥的比較結(jié)果表明,艾司西酞普蘭2周起效(Tau2=0.42;95%CI:-1.35,-0.43;Z=3.82;P0.01);但終點療效與對照藥比較差異不顯著(Tau2=6.04;95%CI:-0.20,0.05;Z=1.18)。安全性比較發(fā)現(xiàn),艾司西酞普蘭的不良反應(yīng)少于其他抗抑郁劑,但差異不顯著。結(jié)論:艾司西酞普蘭治療驚恐障礙起效快,安全性好。
[Abstract]:Objective: to investigate the efficacy and safety of Escitalopram in the treatment of panic disorder in China. Methods: 12 comparative studies of estalopram were reanalyzed by Meta analysis to evaluate the magnitude of combined effect and comprehensive significance test. Results: the self-control before and after the treatment of estalopram showed that the efficacy of Escitalopram was significantly changed (Tau2=4.06;95%CI:1.92,2.28;Z=5.90;P0.01) 2 weeks after treatment of panic disorder. The results of comparison of Escitalopram and control showed that estalopram was effective at 2 weeks (Tau2=0.42;95%CI:-1.35,-0.43;Z=3.82;P0.01), but the end effect was not significantly different from that of control (Tau2=6.04;95%CI:-0.20,0.05;Z=1.18). Safety comparison showed that escitalopram had less adverse reactions than other antidepressants, but the difference was not significant. Conclusion: Escitalopram is effective and safe in the treatment of panic disorder.
【作者單位】： 天津醫(yī)科大學(xué);天津市安定醫(yī)院心境障礙科;
【分類號】：R749.4

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