【摘要】：目的探討CYP3A4和CYP2 D6基因多態(tài)性與海洛因成癮者美沙酮維持治療反應(yīng)的關(guān)聯(lián)性。方法隨機選取6所美沙酮維持治療門診中進行維持治療的海洛因成癮者作為研究對象,收集研究對象的一般社會人口學(xué)特征,相關(guān)吸毒史和美沙酮維持治療信息,并收集外周血測定CYP3A4和CYP2 D6多態(tài)位點的基因型。結(jié)果共納入研究對象820例。其中,治療反應(yīng)好組210例,治療反應(yīng)差組610例。不同治療反應(yīng)組間治療者的年齡比較,差異有統(tǒng)計學(xué)意義(P0.05)。CYP3A4 rs2242480和CYP2 D6 rs16947在治療反應(yīng)好組和治療反應(yīng)差組間的基因型頻率分布和等位基因頻率分布差異均無統(tǒng)計學(xué)意義(均P0.05)。結(jié)論尚未發(fā)現(xiàn)CYP3A4rs2242480和CYP2 D6 rs16947與治療反應(yīng)有關(guān)聯(lián)。
[Abstract]:Objective to investigate the association between CYP3A4 and CYP2 D6 gene polymorphisms and methadone maintenance response in heroin addicts. Methods six heroin addicts undergoing maintenance therapy in methadone maintenance clinic were randomly selected as the study subjects. The general demographic characteristics of the subjects, the history of drug abuse and the information of methadone maintenance therapy were collected. The genotypes of CYP3A4 and CYP2 D6 polymorphic loci were collected from peripheral blood. Results A total of 820 subjects were included. There were 210 cases in the good response group and 610 cases in the poor response group. There was no significant difference in genotype frequency distribution and allele frequency distribution of CYP3A4 rs2242480 and CYP2 D6 rs16947 between the two groups (P0.05). Conclusion CYP3A4rs2242480 and CYP2 D 6 rs16947 have not been found to be associated with the therapeutic response.
【作者單位】： 中南大學(xué)湘雅醫(yī)院;中南大學(xué)湘雅醫(yī)院"移動醫(yī)療"教育部——中國移動聯(lián)合實驗室;中南大學(xué)湘雅公共衛(wèi)生學(xué)院;
【基金】：國家自然科學(xué)基金(81202257)
【分類號】：R749.64
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本文編號：2258127